Inflammasome-mediated innate immunity in Alzheimer's disease.

Venegas, Carmen; HENEKA, Michael

doi:10.1096/fj.201900439

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Inflammasome-mediated innate immunity in Alzheimer's disease.

Venegas, Carmen; HENEKA, Michael

2019 • In FASEB Journal, 33 (12), p. 13075 - 13084

Peer Reviewed verified by ORBi

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https://hdl.handle.net/10993/61697

DOI
10.1096/fj.201900439

PubMed
31702392

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Keywords :

ASC specks; DAMP; neuroinflammation; Amyloid beta-Peptides; Inflammasomes; Alzheimer Disease/immunology; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Animals; Humans; Immunity, Innate/physiology; Inflammasomes/metabolism; Microglia/metabolism; Alzheimer Disease; Immunity, Innate; Microglia; Biotechnology; Biochemistry; Molecular Biology; Genetics

Abstract :

[en] Historically neurodegenerative diseases, Alzheimer's disease (AD) in particular, have been viewed to be primarily caused and driven by neuronal mechanisms. Very recently, due to experimental, genetic, and epidemiologic evidence, immune mechanisms have entered the central stage and are now believed to contribute significantly to risk, onset, and disease progression of this class of disorders. Although immune activation of microglial cells may over time engage various signal transduction pathways, inflammasome activation, which represents a canonical and initiating pathway, seems to be one of the first responses to extracellular β-amyloid (Aβ) accumulation. Here we review the current understanding of inflammasome activation in AD.-Venegas, C., Heneka, M. T. Inflammasome-mediated innate immunity in Alzheimer's disease.

Disciplines :

Neurology

Author, co-author :

Venegas, Carmen; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany

HENEKA, Michael ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany ; German Center for Neurodegenerative Disease (DZNE), Bonn, Germany ; Department of Infectious Diseases and Immunology, University of Massachussetts Medical School, Worcester, Massachusetts, USA

External co-authors :

yes

Language :

English

Title :

Inflammasome-mediated innate immunity in Alzheimer's disease.

Publication date :

December 2019

Journal title :

FASEB Journal

ISSN :

0892-6638

eISSN :

1530-6860

Publisher :

John Wiley and Sons Inc, United States

Volume :

Issue :

Pages :

13075 - 13084

Peer reviewed :

Peer Reviewed verified by ORBi

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https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201900439

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since 22 July 2024

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