[en] Microglia are the brain's resident immune cells. Under physiological conditions, they participate in a myriad of processes mainly involved in housekeeping functions that promote tissue homeostasis. However, the triggering of an immune response is a common feature in neurodegenerative disorders. This shift in microglia cells toward a chronically activated phenotype contributing to neuronal dysfunction and cell death is of great interest nowadays. In this chapter, we review the implications of microglia activation in different neurodegenerative disorders.
Disciplines :
Oncologie
Auteur, co-auteur :
Tejera, Darío; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany ; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
HENEKA, Michael ; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany. Michael.heneka@ukbonn.de ; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. Michael.heneka@ukbonn.de
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