Thoughts on Obesity and Brain Glucose.

Glucose; Alzheimer Disease/metabolism; Brain/metabolism; Diet, High-Fat; Glucose/metabolism; Humans; Obesity/metabolism; Alzheimer Disease; Brain; Obesity; Biochemistry, Genetics and Molecular Biology (all); General Biochemistry, Genetics and Molecular Biology

Abstract :

[en] Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.

Disciplines :

Neurology

Author, co-author :

HENEKA, Michael ; DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany

Nicotera, Pierluigi; DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany. Electronic address: pierluigi.nicotera@dzne.de

External co-authors :

yes

Language :

English

Title :

Thoughts on Obesity and Brain Glucose.

Publication date :

05 May 2016

Journal title :

Cell

ISSN :

0092-8674

eISSN :

1097-4172

Publisher :

Cell Press, United States

Volume :

165

Issue :

Pages :

773 - 775

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0092867416305037?httpAccept=text/xml

Available on ORBilu :

since 16 May 2024

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Bibliography

D.E. Barnes, and K. Yaffe Lancet Neurol. 10 2011 819 828
J.C. Brüning, D. Gautam, D.J. Burks, J. Gillette, M. Schubert, P.C. Orban, R. Klein, W. Krone, D. Müller-Wieland, and C.R. Kahn Science 289 2000 2122 2125
M.T. Heneka, M.P. Kummer, A. Stutz, A. Delekate, S. Schwartz, A. Vieira-Saecker, A. Griep, D. Axt, A. Remus, T.-C. Tzeng, and et al. Nature 493 2013 674 678
A. Jais, M. Solas, H. Backes, B. Chaurasia, A. Kleinridders, S. Theurich, J. Mauer, S.M. Steculorum, B. Hampel, J. Goldau, and et al. Cell 165 2016 882 895 this issue
S.L. Macauley, M. Stanley, E.E. Caesar, S.A. Yamada, M.E. Raichle, R. Perez, T.E. Mahan, C.L. Sutphen, and D.M. Holtzman J. Clin. Invest. 125 2015 2463 2467
D. Petrov, I. Pedrós, G. Artiach, F.X. Sureda, E. Barroso, M. Pallàs, G. Casadesús, C. Beas-Zarate, E. Carro, I. Ferrer, and et al. Biochim. Biophys. Acta 1852 2015 1687 1699
G. Sabio, M. Das, A. Mora, Z. Zhang, J.Y. Jun, H.J. Ko, T. Barrett, J.K. Kim, and R.J. Davis Science 322 2008 1539 1543
A.M. Stranahan, E.D. Norman, K. Lee, R.G. Cutler, R.S. Telljohann, J.M. Egan, and M.P. Mattson Hippocampus 18 2008 1085 1088
R.A. Whitmer, D.R. Gustafson, E. Barrett-Connor, M.N. Haan, E.P. Gunderson, and K. Yaffe Neurology 71 2008 1057 1064
E.A. Winkler, Y. Nishida, A.P. Sagare, S.V. Rege, R.D. Bell, D. Perlmutter, J.D. Sengillo, S. Hillman, P. Kong, A.R. Nelson, and et al. Nat. Neurosci. 18 2015 521 530