Glucose; Alzheimer Disease/metabolism; Brain/metabolism; Diet, High-Fat; Glucose/metabolism; Humans; Obesity/metabolism; Alzheimer Disease; Brain; Obesity; Biochemistry, Genetics and Molecular Biology (all); General Biochemistry, Genetics and Molecular Biology
Résumé :
[en] Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.
Disciplines :
Neurologie
Auteur, co-auteur :
HENEKA, Michael ; DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany
Nicotera, Pierluigi; DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany. Electronic address: pierluigi.nicotera@dzne.de
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