Animals; Humans; Microglia/pathology; Neurodegenerative Diseases/pathology; Microglia; Neurodegenerative Diseases; Immunology and Allergy; Immunology; General Medicine
Résumé :
[en] After many years of being largely neglected in neurodegenerative disease, the past few years have seen a turning point in the field’s view on the impact of microglia in neurological disorders. 2018 has been another exciting year with a number of great contributions in this area.
Disciplines :
Neurologie
Auteur, co-auteur :
HENEKA, Michael ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn, Bonn, Germany. michael.heneka@ukbonn.de ; German Center for Neurodegenerative Diseases, Bonn, Germany. michael.heneka@ukbonn.de ; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA. michael.heneka@ukbonn.de
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Microglia take centre stage in neurodegenerative disease.
Date de publication/diffusion :
février 2019
Titre du périodique :
Nature Reviews. Immunology
ISSN :
1474-1733
eISSN :
1474-1741
Maison d'édition :
Nature Publishing Group, Basingstoke, Hampshire, England
M.T.H. is supported by grants from the Deutsche Forschungsgesellschaft (SFB 1089, excellence cluster ImmunoSensation) and by the European Union Joint Programme–Neurodegenerative Disease (JPND) consortium InCure (funding code 01ED1505A).
Qin, Y. et al. A milieu molecule for TGFβ required for microglia function in the nervous system. Cell 174, 156–171 (2018)
Bussian, T. J. et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562, 578–582 (2018)
Brelstaff, J. et al. Living neurons with tau filaments aberrantly expose phosphatidylserine and are phagocytosed by microglia. Cell Rep. 24, 1939–1948 (2018)
Locatelli, G. et al. Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat. Neurosci. 21, 1196–1208 (2018)
Huang, Y. et al. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nat. Neurosci. 21, 530–540 (2018)
Spiller, K. J. et al. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nat. Neurosci. 21, 329–340 (2018)
