Microglia take centre stage in neurodegenerative disease.

Animals; Humans; Microglia/pathology; Neurodegenerative Diseases/pathology; Microglia; Neurodegenerative Diseases; Immunology and Allergy; Immunology; General Medicine

Abstract :

[en] After many years of being largely neglected in neurodegenerative disease, the past few years have seen a turning point in the field’s view on the impact of microglia in neurological disorders. 2018 has been another exciting year with a number of great contributions in this area.

Disciplines :

Neurology

Author, co-author :

HENEKA, Michael ; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn, Bonn, Germany. michael.heneka@ukbonn.de ; German Center for Neurodegenerative Diseases, Bonn, Germany. michael.heneka@ukbonn.de ; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA. michael.heneka@ukbonn.de

External co-authors :

yes

Language :

English

Title :

Microglia take centre stage in neurodegenerative disease.

Publication date :

February 2019

Journal title :

Nature Reviews. Immunology

ISSN :

1474-1733

eISSN :

1474-1741

Publisher :

Nature Publishing Group, Basingstoke, Hampshire, England

Volume :

Issue :

Pages :

79 - 80

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.nature.com/articles/s41577-018-0112-5

Funding text :

M.T.H. is supported by grants from the Deutsche Forschungsgesellschaft (SFB 1089, excellence cluster ImmunoSensation) and by the European Union Joint Programme–Neurodegenerative Disease (JPND) consortium InCure (funding code 01ED1505A).

Available on ORBilu :

since 08 May 2024

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Bibliography

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Locatelli, G. et al. Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat. Neurosci. 21, 1196–1208 (2018)
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Spiller, K. J. et al. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nat. Neurosci. 21, 329–340 (2018)