[en] [en] OBJECTIVE: To investigate whether the occurrence or clearance of microhemorrhages in cerebral amyloid angiopathy (CAA)-related vascular inflammation can be modified by immunosuppressive treatment.
METHODS: Clinical and radiologic follow-up for more than 5 years of a patient with histopathologically confirmed CAA-related vascular inflammation treated with a prolonged and tapered regimen of IV cyclophosphamide and oral steroids.
RESULTS: Under long-term immunosuppressive treatment, a reduced number of cortical micobleeds was observed on repeat MRIs because of both the prevention of new microbleeds and the clearance of those existing at baseline.
CONCLUSIONS: Sustained immunosuppression should be considered and systematically investigated as a treatment option for cortical microbleeds in CAA and related inflammatory phenotypes.
CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence. This is a single observational study without controls.
Disciplines :
Neurology
Author, co-author :
Traschütz, Andreas; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
Tzaridis, Theophilos; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
Penner, Arndt-Hendrik; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
Kuchelmeister, Klaus; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
Urbach, Horst; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
Hattingen, Elke; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
HENEKA, Michael ; Departments of Neurology (A.T., T.T., M.T.H.), Neuroradiology (A.-H.P., E.H.), and Neuropathology (K.K.), University of Bonn, Germany, Department of Neuroradiology (H.U.), University of Freiburg, Germany, and German Center for Neurodegenerative Disease (M.T.H.), Bonn, Germany
External co-authors :
yes
Language :
English
Title :
Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation.
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