[en] Abstract: Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as 'cold tumours' with very little lymphocyte infiltration, they can contain up to 30-40% of tumour-associated macrophages, reported to contribute to a supportive microenvironment that facilitates tumour proliferation, survival and migration. In GBM, tumour-associated macrophages comprise either resident parenchymal microglia, perivascular macrophages or peripheral monocyte-derived cells. They are recruited by GBMs and in turn release growth factors and cytokines that affect the tumour. Notably, tumour-associated microglia/macrophages (TAMs) acquire different expression programs, which shape the tumour microenvironment and contribute to GBM molecular subtyping. Further, emerging evidence highlights that TAM programs may adapt to specific tumour features and landscapes. Here, we review key evidence describing TAM transcriptional and functional heterogeneity in GBM. We propose that unravelling the intricate complexity and diversity of the myeloid compartment as well as understanding how different TAM subsets may affect tumour progression will possibly pave the way to new immune therapeutic avenues for GBM patients.
Disciplines :
Oncologie
Auteur, co-auteur :
Pires-Afonso, Yolanda ; Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg. ; Doctoral School of Science and Technology, University of Luxembourg, L-4365 Esch-sur-Alzette, Luxembourg.
NICLOU, Simone P. ; NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg. ; Department of Biomedicine, University of Bergen, N-5007 Bergen, Norway.
MICHELUCCI, Alessandro ; Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma.
Date de publication/diffusion :
21 janvier 2020
Titre du périodique :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Maison d'édition :
Multidisciplinary Digital Publishing Institute (MDPI), Suisse
Volume/Tome :
21
Fascicule/Saison :
3
Peer reviewed :
Peer reviewed vérifié par ORBi
N° du Fonds :
PRIDE15/10675146/CANBIO/Fonds National de la Recherche Luxembourg/
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