Profil

NICLOU Simone P.

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

Main Referenced Co-authors
Bjerkvig, Rolf (31)
Stieber, Daniel (16)
GOLEBIEWSKA, Anna  (14)
Keunen, Olivier (14)
Miletic, Hrvoje (13)
Main Referenced Keywords
Humans (54); Animals (49); Mice (20); Rats (18); Female (11);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Integrative Cell Signalling (Skupin Group) (2)
CRP SANTE - Centre de Recherche Public de la Santé (1)
Departmanet of Life Sciences and Medicine (1)
LIH - Luxembourg Institute of Health (1)
Main Referenced Disciplines
Oncology (78)
Neurology (7)
Life sciences: Multidisciplinary, general & others (5)
Biochemistry, biophysics & molecular biology (3)
Genetics & genetic processes (2)

Publications (total 92)

The most downloaded
191 downloads
Pavlou, M. A., Grandbarbe, L., Buckley, N., Niclou, S., & Michelucci, A. (2018). Transcriptional and epigenetic mechanisms underlying astrocyte identity. Progress in Neurobiology. doi:10.1016/j.pneurobio.2018.12.007 https://hdl.handle.net/10993/38704

The most cited

1986 citations (OpenCitations)

Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., Quek, K., Quinn, M. C. J., Robertson, A. J., Fadlullah, M. Z. H., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., ... Hair, J. (Other coll.). (26 February 2015). Whole genomes redefine the mutational landscape of pancreatic cancer. Nature, 518 (7540), 495-501. doi:10.1038/nature14169 https://hdl.handle.net/10993/60218

Oudin, A., Moreno-Sanchez, P. M., Baus, V., NICLOU, S. P., & GOLEBIEWSKA, A. (02 January 2024). Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence. BMC Cancer, 24 (1), 3. doi:10.1186/s12885-023-11774-6
Peer Reviewed verified by ORBi

Nesseler, J. P., Schaue, D., McBride, W. H., Lee, M.-H., Kaprealian, T., NICLOU, S. P., & Nickers, P. (2024). Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. Advances in Radiation Oncology, 4 (2), 268-282. doi:10.1016/j.adro.2018.11.005
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Nassiri, F., Aldape, K., Alhuwalia, M., Brastianos, P., Ducray, F., Galldiks, N., Kim, A., Lamszus, K., Mitchell, D., Nabors, L. B., Nam, D.-H., Natsume, A., Ng, H.-K., NICLOU, S. P., Sahm, F., Short, S., Walsh, K., Wick, W., & Zadeh, G. (2024). Highlights of the inaugural ten - the launch of Neuro-Oncology Advances. Neuro-Oncology Advances, 1 (1), 016. doi:10.1093/noajnl/vdz016
Peer Reviewed verified by ORBi

NICLOU, S. P., Ehlert, E. M. E., & Verhaagen, J. (2024). Chemorepellent axon guidance molecules in spinal cord injury. Journal of Neurotrauma, 23 (3-4), 409-21. doi:10.1089/neu.2006.23.409
Peer Reviewed verified by ORBi

Erasimus, H., GOBIN, M., NICLOU, S. P., & Van Dyck, E. (2024). DNA repair mechanisms and their clinical impact in glioblastoma. Mutation Research - Reviews in Mutation Research, 769, 19-35. doi:10.1016/j.mrrev.2016.05.005
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Malta, T. M., Sabedot, T. S., Morosini, N. S., Datta, I., Garofano, L., Vallentgoed, W. R., Varn, F. S., Aldape, K., D'Angelo, F., Bakas, S., Barnholtz-Sloan, J. S., Gan, H. K., Hasanain, M., Hau, A.-C., Johnson, K. C., Cazacu, S., deCarvalho, A. C., Khasraw, M., Kocakavuk, E., ... Noushmehr, H. (2023). The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen. Cancer Research. doi:10.1158/0008-5472.CAN-23-2093
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Yabo, Y. A., Moreno-Sanchez, P. M., Pires-Afonso, Y., Kaoma, T., Nosirov, B., Scafidi, A., Ermini, L., Lipsa, A., Oudin, A., KYRIAKIS, D., GRZYB, K., POOVATHINGAL, S. K., Poli, A., Muller, A., TOTH, R., KLINK, B., BERCHEM, G. J. M. J., Berthold, C., HERTEL, F., ... GOLEBIEWSKA, A. (2023). Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/60199. doi:10.1101/2023.03.05.531162

Le Rhun, E., Boele, F., Minniti, G., Galldiks, N., Taphoorn, M., Piil, K., Rudà, R., NICLOU, S. P., Geurts, M., Preusser, M., Weller, M., Short, S. C., & Dirven, L. (2023). Gender balance and suitable positive actions to promote gender equality among healthcare professionals in neuro-oncology: The EANO positive action initiative. Neuro-Oncology Practice. doi:10.1093/nop/npad064
Peer reviewed

Capper, D., Reifenberger, G., French, P. J., Schweizer, L., Weller, M., Touat, M., NICLOU, S. P., Euskirchen, P., Haberler, C., Hegi, M. E., Brandner, S., Le Rhun, E., Rudà, R., Sanson, M., Tabatabai, G., Sahm, F., Wen, P. Y., Wesseling, P., Preusser, M., & van den Bent, M. J. (04 May 2023). EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection. Neuro-Oncology, 25 (5), 813-826. doi:10.1093/neuonc/noad008
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Pati, S., Baid, U., Edwards, B., Sheller, M., Wang, S.-H., Reina, G. A., Foley, P., Gruzdev, A., Karkada, D., Davatzikos, C., Sako, C., Ghodasara, S., Bilello, M., Mohan, S., Vollmuth, P., Brugnara, G., Preetha, C. J., Sahm, F., Maier-Hein, K., ... Bakas, S. (26 January 2023). Author Correction: Federated learning enables big data for rare cancer boundary detection. Nature Communications, 14 (1), 436. doi:10.1038/s41467-023-36188-7
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Pati, S., Baid, U., Edwards, B., Sheller, M., Wang, S.-H., Reina, G. A., Foley, P., Gruzdev, A., Karkada, D., Davatzikos, C., Sako, C., Ghodasara, S., Bilello, M., Mohan, S., Vollmuth, P., Brugnara, G., Preetha, C. J., Sahm, F., Maier-Hein, K., ... Bakas, S. (05 December 2022). Federated learning enables big data for rare cancer boundary detection. Nature Communications, 13 (1), 7346. doi:10.1038/s41467-022-33407-5
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Pires-Afonso, Y., Muller, A., GRZYB, K., Oudin, A., Yabo, Y. A., SOUSA, C., Scafidi, A., Poli, A., COSMA, A., HALDER, R., COOWAR, D., GOLEBIEWSKA, A., SKUPIN, A., NICLOU, S. P., & MICHELUCCI, A. (September 2022). Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency. Molecular Oncology, 16 (17), 3167 - 3191. doi:10.1002/1878-0261.13287
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Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., Fankhauser, L., Garofano, L., Freudenberg, A., Wagner, J., Tanev, D. I., Ratliff, M., Xie, R., Kessler, T., Hoffmann, D. C., ... Winkler, F. (04 August 2022). Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell, 185 (16), 2899-2917.e31. doi:10.1016/j.cell.2022.06.054
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ILINA, E., CIALINI, C., GERLOFF, D., Duarte Garcia-Escudero, M., Jeanty, C., Thézénas, M.-L., Lesur, A., Puard, V., Bernardin, F., Moter, A., Schuster, A., Dieterle, M., GOLEBIEWSKA, A., GERARDY, J.-J., DITTMAR, G., NICLOU, S. P., Müller, T., & MITTELBRONN, M. (18 February 2022). Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration. iScience, 25 (2), 103842. doi:10.1016/j.isci.2022.103842
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Kishk, A., Pires Pacheco, M. I., Heurtaux, T., Sinkkonen, L., Pang, J., Fritah, S., Niclou, S., & Sauter, T. (2022). Review of Current Human Genome-Scale Metabolic Models for Brain Cancer and Neurodegenerative Diseases. Cells, 11 (16). doi:10.3390/cells11162486
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NICLOU, S. P., & GOLEBIEWSKA, A. (April 2021). Turning strength into weakness: protein degradation and autophagy as therapeutic targets in glioblastoma? Neuro-Oncology, 23 (7), 1041–1043. doi:10.1093/neuonc/noab099
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Fabian, C., Han, M., Bjerkvig, R., & NICLOU, S. P. (2021). Novel facets of glioma invasion. International Review of Cell and Molecular Biology, 360, 33-64. doi:10.1016/bs.ircmb.2020.08.001
Peer reviewed

Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., ... Niclou, S. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. doi:10.1007/s00401-020-02226-7
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Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., ... Niclou, S. (2020). Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/43022. doi:10.1101/2020.04.24.057802

Keunen, O., & NICLOU, S. P. (2020). Is there a prominent role for MR spectroscopy in the clinical management of brain tumors? Neuro-Oncology. doi:10.1093/neuonc/noaa098
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Le Rhun, E., Weller, M., NICLOU, S. P., Short, S., Piil, K., Boele, F., Rudà, R., Theodorou, M., Brandsma, D., van den Bent, M., & Dirven, L. (March 2020). Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey. Neuro-Oncology Practice, 7 (2), 249-259. doi:10.1093/nop/npz053
Peer reviewed

FRITAH, S., & NICLOU, S. P. (2020). Dual blockade of STAT3 and EGFR: a key to unlock drug resistance in glioblastoma? Neuro-Oncology. doi:10.1093/neuonc/noaa039
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Pires-Afonso, Y., NICLOU, S. P., & MICHELUCCI, A. (21 January 2020). Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma. International Journal of Molecular Sciences, 21 (3). doi:10.3390/ijms21030689
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Biedermann, J., Preussler, M., Conde, M., Peitzsch, M., Richter, S., Wiedemuth, R., Abou-El-Ardat, K., Krüger, A., Meinhardt, M., Schackert, G., Leenders, W. P., Herold-Mende, C., NICLOU, S. P., Bjerkvig, R., Eisenhofer, G., Temme, A., Seifert, M., Kunz-Schughart, L. A., Schröck, E., & KLINK, B. (16 December 2019). Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin. Cancers, 11 (12). doi:10.3390/cancers11122028
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Barthel, F. P., Johnson, K. C., Varn, F. S., Moskalik, A. D., Tanner, G., Kocakavuk, E., Anderson, K. J., Abiola, O., Aldape, K., Alfaro, K. D., Alpar, D., Amin, S. B., Ashley, D. M., Bandopadhayay, P., Barnholtz-Sloan, J. S., Beroukhim, R., Bock, C., Brastianos, P. K., Brat, D. J., ... Verhaak, R. G. W. (Other coll.). (December 2019). Longitudinal molecular trajectories of diffuse glioma in adults. Nature, 576 (7785), 112-120. doi:10.1038/s41586-019-1775-1
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Dirkse, A., Golebiewska, A., Buder, T., Nazarov, P. V., Muller, A., Poovathingal, S., Brons, N. H. C., Leite, S., Sauvageot, N., Sarkisjan, D., Seyfrid, M., Fritah, S., Stieber, D., Michelucci, A., Herold-Mende, C., Bjerkvig, R., Azuaje, F., Skupin, A., Deutsch, A., ... Hertel, F. (2019). Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nature communications, 10 (1), 1787. doi:10.1038/s41467-019-09853-z
Peer reviewed

Pavlou, M. A., Grandbarbe, L., Buckley, N., Niclou, S., & Michelucci, A. (2018). Transcriptional and epigenetic mechanisms underlying astrocyte identity. Progress in Neurobiology. doi:10.1016/j.pneurobio.2018.12.007
Peer Reviewed verified by ORBi

NICLOU, S. P. (09 October 2018). Revival of the VEGF ligand family? Neuro-Oncology, 20 (11), 1421-1422. doi:10.1093/neuonc/noy127
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Obad, N., Espedal, H., Jirik, R., Sakariassen, P. O., Brekke Rygh, C., Lund-Johansen, M., Taxt, T., NICLOU, S. P., Bjerkvig, R., & Keunen, O. (October 2018). Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma. Journal of Cerebral Blood Flow and Metabolism, 38 (10), 1741-1753. doi:10.1177/0271678X17714656
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Sousa, C., Golebiewska, A., Poovathingal, S. K., Kaoma, T., Pires-Afonso, Y., Martina, S., Coowar, D., Azuaje, F., Skupin, A., Balling, R., Biber, K., Niclou, S., & Michelucci, A. (2018). Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Reports. doi:10.15252/embr.201846171
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MEISER, J., Schuster, A., Pietzke, M., Vande Voorde, J., Athineos, D., Oizel, K., Burgos-Barragan, G., Wit, N., Dhayade, S., Morton, J. P., Dornier, E., Sumpton, D., Mackay, G. M., Blyth, K., Patel, K. J., NICLOU, S. P., & Vazquez, A. (10 April 2018). Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9 (1), 1368. doi:10.1038/s41467-018-03777-w
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Neirinckx, V., Hedman, H., & NICLOU, S. P. (August 2017). Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy. Biochimica et Biophysica Acta - Reviews on Cancer, 1868 (1), 109-116. doi:10.1016/j.bbcan.2017.02.007
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Monaco, I., Camorani, S., Colecchia, D., Locatelli, E., Calandro, P., Oudin, A., NICLOU, S. P., Arra, C., Chiariello, M., Cerchia, L., & Comes Franchini, M. (25 May 2017). Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier. Journal of Medicinal Chemistry, 60 (10), 4510-4516. doi:10.1021/acs.jmedchem.7b00527
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Eskilsson, E., Rosland, G. V., Talasila, K. M., Knappskog, S., Keunen, O., Sottoriva, A., Foerster, S., Solecki, G., Taxt, T., Jirik, R., FRITAH, S., Harter, P. N., Välk, K., Al Hossain, J., Joseph, J. V., Jahedi, R., Saed, H. S., Piccirillo, S. G., Spiteri, I., ... Miletic, H. (December 2016). EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro-Oncology, 18 (12), 1644 - 1655. doi:10.1093/neuonc/now113
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Rodius, S., Androsova, G., Götz, L., Liechti, R., Crespo, I., Merz, S., Nazarov, P., de Klein, N., Jeanty, C., González-Rosa, J., Muller, A., Bernardin, F., Niclou, S., Vallar, L., Mercader, N., Ibberson, M., Xenarios, I., & Azuaje, F. (31 May 2016). Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Scientific Reports, 6. doi:10.1038/srep26822
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Bougnaud, S., GOLEBIEWSKA, A., Oudin, A., Keunen, O., Harter, P. N., Mäder, L., AZUAJE, F., FRITAH, S., Stieber, D., Kaoma, T., Vallar, L., Brons, N. H. C., Daubon, T., Miletic, H., Sundstrøm, T., Herold-Mende, C., MITTELBRONN, M., Bjerkvig, R., & NICLOU, S. P. (31 May 2016). Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma. Oncotarget, 7 (22), 31955 - 31971. doi:10.18632/oncotarget.7454
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Du Four, S., Maenhout, S. K., NICLOU, S. P., Thielemans, K., Neyns, B., & Aerts, J. L. (2016). Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs. American Journal of Cancer Research, 6 (11), 2514-2531.
Peer reviewed

Tardito, S., Oudin, A., Ahmed, S. U., Fack, F., Keunen, O., Zheng, L., Miletic, H., Sakariassen, P. Ø., Weinstock, A., Wagner, A., Lindsay, S. L., Hock, A. K., Barnett, S. C., Ruppin, E., Mørkve, S. H., Lund-Johansen, M., Chalmers, A. J., Bjerkvig, R., NICLOU, S. P., & Gottlieb, E. (December 2015). Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology, 17 (12), 1556 - 1568. doi:10.1038/ncb3272
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Burtey, A., Wagner, M., Hodneland, E., Skaftnesmo, K. O., Schoelermann, J., Mondragon, I. R., Espedal, H., GOLEBIEWSKA, A., NICLOU, S. P., Bjerkvig, R., Kögel, T., & Gerdes, H.-H. (November 2015). Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes. FASEB Journal, 29 (11), 4695-712. doi:10.1096/fj.14-268615
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NICLOU, S. P. (July 2015). Gauging heterogeneity in primary versus recurrent glioblastoma. Neuro-Oncology, 17 (7), 907-9. doi:10.1093/neuonc/nov078
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Du Four, S., Maenhout, S. K., De Pierre, K., Renmans, D., NICLOU, S. P., Thielemans, K., Neyns, B., & Aerts, J. L. (April 2015). Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model. Oncoimmunology, 4 (4), 998107. doi:10.1080/2162402X.2014.998107
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AZUAJE, F., Tiemann, K., & NICLOU, S. P. (31 March 2015). Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma. Cell Communication and Signaling, 13, 23. doi:10.1186/s12964-015-0098-6
Peer Reviewed verified by ORBi

Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., Quek, K., Quinn, M. C. J., Robertson, A. J., Fadlullah, M. Z. H., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., ... Hair, J. (Other coll.). (26 February 2015). Whole genomes redefine the mutational landscape of pancreatic cancer. Nature, 518 (7540), 495-501. doi:10.1038/nature14169
Peer Reviewed verified by ORBi

Sanzey, M., Abdul Rahim, S. A., Oudin, A., Dirkse, A., Kaoma, T., Vallar, L., Herold-Mende, C., Bjerkvig, R., GOLEBIEWSKA, A., & NICLOU, S. P. (2015). Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma. PLoS ONE, 10 (5), 0123544. doi:10.1371/journal.pone.0123544
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Bhujbal, S. V., de Haan, B., NICLOU, S. P., & de Vos, P. (31 October 2014). A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells. Scientific Reports, 4, 6856. doi:10.1038/srep06856
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Keunen, O., Taxt, T., Grüner, R., Lund-Johansen, M., Tonn, J.-C., Pavlin, T., Bjerkvig, R., NICLOU, S. P., & Thorsen, F. (30 September 2014). Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Advanced Drug Delivery Reviews, 76, 98-115. doi:10.1016/j.addr.2014.07.010
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Androsova, G., Rodius, S., Nazarov, P., Muller, A., Bernardin, F., Jeanty, C., Niclou, S., Vallar, L., & Azuaje, F. (08 September 2014). A comprehensive integrative analysis of the transcriptional network underlying the zebrafish heart regeneration [Poster presentation]. European Conference on Computational Biology, Strasbourg, France.

Bhujbal, S. V., Paredes-Juarez, G. A., NICLOU, S. P., & de Vos, P. (September 2014). Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells. Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208. doi:10.1016/j.jmbbm.2014.05.020
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van Lith, S. A. M., Navis, A. C., Verrijp, K., NICLOU, S. P., Bjerkvig, R., Wesseling, P., Tops, B., Molenaar, R., van Noorden, C. J. F., & Leenders, W. P. J. (August 2014). Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers? Biochimica et Biophysica Acta, 1846 (1), 66-74. doi:10.1016/j.bbcan.2014.04.004
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Torsvik, A., Stieber, D., Enger, P. Ø., GOLEBIEWSKA, A., Molven, A., Svendsen, A., Westermark, B., NICLOU, S. P., Olsen, T. K., Chekenya Enger, M., & Bjerkvig, R. (August 2014). U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells. Cancer Medicine, 3 (4), 812-24. doi:10.1002/cam4.219
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Fathpour, P., Obad, N., Espedal, H., Stieber, D., Keunen, O., Sakariassen, P. Ø., NICLOU, S. P., & Bjerkvig, R. (May 2014). Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment? Neuro-Oncology, 16 (5), 754-6. doi:10.1093/neuonc/nou013
Peer Reviewed verified by ORBi

Bhujbal, S. V., de Vos, P., & NICLOU, S. P. (April 2014). Drug and cell encapsulation: alternative delivery options for the treatment of malignant brain tumors. Advanced Drug Delivery Reviews, 67-68, 142-53. doi:10.1016/j.addr.2014.01.010
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Stieber, D., Golebiewska, A., Evers, L., Lenkiewicz, E., Brons, N. H. C., Nicot, N., Oudin, A., Bougnaud, S., Hertel, F., Bjerkvig, R., Vallar, L., Barrett, M. T., & Niclou, S. (2014). Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes. Acta Neuropathologica, 127 (2), 203-19. doi:10.1007/s00401-013-1196-4
Peer Reviewed verified by ORBi

Rajcevic, U., Knol, J. C., Piersma, S., Bougnaud, S., Fack, F., Sundlisaeter, E., Søndenaa, K., Myklebust, R., Pham, T. V., NICLOU, S. P., & Jiménez, C. R. (2014). Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture. Proteome Science, 12, 39. doi:10.1186/1477-5956-12-39
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Demeure, K., DURIEZ, E., Domon, B., & NICLOU, S. P. (2014). PeptideManager: a peptide selection tool for targeted proteomic studies involving mixed samples from different species. Frontiers in Genetics, 5, 305. doi:10.3389/fgene.2014.00305
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Johansson, M., Oudin, A., Tiemann, K., Bernard, A., GOLEBIEWSKA, A., Keunen, O., Fack, F., Stieber, D., Wang, B., Hedman, H., & NICLOU, S. P. (September 2013). The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status. Neuro-Oncology, 15 (9), 1200-11. doi:10.1093/neuonc/not054
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Daphu, I., Sundstrøm, T., Horn, S., Huszthy, P. C., NICLOU, S. P., Sakariassen, P. Ø., Immervoll, H., Miletic, H., Bjerkvig, R., & Thorsen, F. (June 2013). In vivo animal models for studying brain metastasis: value and limitations. Clinical and Experimental Metastasis, 30 (5), 695-710. doi:10.1007/s10585-013-9566-9
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Kofanova, O. A., Fack, F., NICLOU, S. P., & BETSOU, F. (June 2013). Combined effect of tissue stabilization and protein extraction methods on phosphoprotein analysis. Biopreservation and Biobanking, 11 (3), 161-5. doi:10.1089/bio.2013.0008
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Navis, A. C., NICLOU, S. P., Fack, F., Stieber, D., van Lith, S., Verrijp, K., Wright, A., Stauber, J., Tops, B., Otte-Holler, I., Wevers, R. A., van Rooij, A., Pusch, S., von Deimling, A., Tigchelaar, W., van Noorden, C. J. F., Wesseling, P., & Leenders, W. P. J. (29 May 2013). Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG. Acta Neuropathologica Communications, 1, 18. doi:10.1186/2051-5960-1-18
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Talasila, K. M., Soentgerath, A., Euskirchen, P., Rosland, G. V., Wang, J., Huszthy, P. C., Prestegarden, L., Skaftnesmo, K. O., Sakariassen, P. Ø., Eskilsson, E., Stieber, D., Keunen, O., Brekka, N., Moen, I., Nigro, J. M., Vintermyr, O. K., Lund-Johansen, M., NICLOU, S. P., Mørk, S. J., ... Miletic, H. (May 2013). EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathologica, 125 (5), 683-98. doi:10.1007/s00401-013-1101-1
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Golebiewska, A., Bougnaud, S., Stieber, D., Brons, N. H. C., Vallar, L., Hertel, F., Klink, B., Schrock, E., Bjerkvig, R., & Niclou, S. (2013). Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain: a Journal of Neurology, 136 (Pt 5), 1462-75. doi:10.1093/brain/awt025
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Talasila, K. M., Brekka, N., Mangseth, K., Stieber, D., Evensen, L., Rosland, G. V., Torsvik, A., Wagner, M., NICLOU, S. P., Mahesparan, R., Vintermyr, O. K., Bjerkvig, R., Nigro, J. M., & Miletic, H. (2013). Tumor versus stromal cells in culture--survival of the fittest? PLoS ONE, 8 (12), 81183. doi:10.1371/journal.pone.0081183
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Petersen, K., Rajcevic, U., Abdul Rahim, S. A., Jonassen, I., Kalland, K.-H., Jimenez, C. R., Bjerkvig, R., & NICLOU, S. P. (2013). Gene set based integrated data analysis reveals phenotypic differences in a brain cancer model. PLoS ONE, 8 (7), 68288. doi:10.1371/journal.pone.0068288
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B, K., H, M., D, S., PC, H., JAC, V., J, B., J, W., M, S., PØ, S., T, S., A, T., M, A., JM, N., & NICLOU, S. P. (2013). Correction: A Novel, Diffusely Infiltrative Xenograft Model of Human Anaplastic Oligodendroglioma with Mutations in FUBP1, CIC, and IDH1. PLoS ONE. doi:10.1371/annotation/72a01ce5-b0ad-4cbd-ac77-0a81347a3940
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B, K., H, M., D, S., PC, H., JA, C., J, B., J, W., M, S., PØ, S., T, S., A, T., M, A., JM, N., & NICLOU, S. P. (2013). A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLoS ONE. doi:10.1371/journal.pone.0059773
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Huszthy, P. C., Daphu, I., NICLOU, S. P., Stieber, D., Nigro, J. M., Sakariassen, P. Ø., Miletic, H., Thorsen, F., & Bjerkvig, R. (August 2012). In vivo models of primary brain tumors: pitfalls and perspectives. Neuro-Oncology, 14 (8), 979-93. doi:10.1093/neuonc/nos135
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Viel, T., Talasila, K. M., Monfared, P., Wang, J., Jikeli, J. F., Waerzeggers, Y., Neumaier, B., Backes, H., Brekka, N., Thorsen, F., Stieber, D., NICLOU, S. P., Winkeler, A., Tavitian, B., Hoehn, M., Bjerkvig, R., Miletic, H., & Jacobs, A. H. (July 2012). Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. Journal of Nuclear Medicine, 53 (7), 1135-45. doi:10.2967/jnumed.111.101659
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Stieber, D., Abdul Rahim, S. A., & NICLOU, S. P. (October 2011). Novel ways to target brain tumour metabolism. Expert Opinion on Therapeutic Targets, 15 (10), 1227-39. doi:10.1517/14728222.2011.588211
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Keunen, O., Johansson, M., Oudin, A., Sanzey, M., Rahim, S. A. A., Fack, F., Thorsen, F., Taxt, T., Bartos, M., Jirik, R., Miletic, H., Wang, J., Stieber, D., Stuhr, L., Moen, I., Rygh, C. B., Bjerkvig, R., & NICLOU, S. P. (01 March 2011). Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America, 108 (9), 3749-54. doi:10.1073/pnas.1014480108
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GOLEBIEWSKA, A., Brons, N. H. C., Bjerkvig, R., & NICLOU, S. P. (04 February 2011). Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell, 8 (2), 136-47. doi:10.1016/j.stem.2011.01.007
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Goplen, D., Bougnaud, S., Rajcevic, U., Bøe, S. O., Skaftnesmo, K. O., Voges, J., Enger, P. Ø., Wang, J., Tysnes, B. B., Laerum, O. D., NICLOU, S. P., & Bjerkvig, R. (October 2010). αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. American Journal of Pathology, 177 (4), 1618-28. doi:10.2353/ajpath.2010.090063
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NICLOU, S. P., Fack, F., & Rajcevic, U. (10 September 2010). Glioma proteomics: status and perspectives. Journal of Proteomics, 73 (10), 1823-38. doi:10.1016/j.jprot.2010.03.007
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Ehlert, E. M., Eggers, R., NICLOU, S. P., & Verhaagen, J. (18 February 2010). Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system. BMC Neuroscience, 11, 20. doi:10.1186/1471-2202-11-20
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Rajcevic, U., Petersen, K., Knol, J. C., Loos, M., Bougnaud, S., Klychnikov, O., Li, K. W., Pham, T. V., Wang, J., Miletic, H., Peng, Z., Bjerkvig, R., Jimenez, C. R., & NICLOU, S. P. (November 2009). iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Molecular and Cellular Proteomics, 8 (11), 2595-612. doi:10.1074/mcp.M900124-MCP200
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Miletic, H., NICLOU, S. P., Johansson, M., & Bjerkvig, R. (April 2009). Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Expert Opinion on Therapeutic Targets, 13 (4), 455-68. doi:10.1517/14728220902806444
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Rajcevic, U., NICLOU, S. P., & Jimenez, C. R. (01 January 2009). Proteomics strategies for target identification and biomarker discovery in cancer. doi:10.2741/3452
Peer reviewed

NICLOU, S. P., Danzeisen, C., Eikesdal, H. P., Wiig, H., Brons, N. H. C., Poli, A. M. F., Svendsen, A., Torsvik, A., Enger, P. Ø., Terzis, J. A., & Bjerkvig, R. (September 2008). A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. FASEB Journal, 22 (9), 3120-8. doi:10.1096/fj.08-109611
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Johansson, U., Rasmusson, I., NICLOU, S. P., Forslund, N., Gustavsson, L., Nilsson, B., Korsgren, O., & Magnusson, P. U. (September 2008). Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization. Diabetes, 57 (9), 2393-401. doi:10.2337/db07-0981
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Terzis, A. J. A., NICLOU, S. P., Rajcevic, U., Danzeisen, C., & Bjerkvig, R. (August 2006). Cell therapies for glioblastoma. Expert Opinion on Biological Therapy, 6 (8), 739-49. doi:10.1517/14712598.6.8.739
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F, D., T, V., FJ, S., LA, W., PR, B., van Muiswinkel FL, J, V., & NICLOU, S. P. (2006). The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Molecular and Cellular Neuroscience. doi:10.1016/j.mcn.2006.03.002
Peer reviewed

HH, M., S, C., NICLOU, S. P., RS, N., A, W., MG, W., KE, R., MG, S., & A, C. (2006). A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. Journal of Neuroscience. doi:10.1523/jneurosci.0702-05.2006
Peer reviewed

Hu, Y., Leaver, S. G., Plant, G. W., Hendriks, W. T. J., NICLOU, S. P., Verhaagen, J., Harvey, A. R., & Cui, Q. (June 2005). Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration. Molecular Therapy, 11 (6), 906-15. doi:10.1016/j.ymthe.2005.01.016
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Sinnreich, M., Meins, M., NICLOU, S. P., Suidan, H. S., & Monard, D. (March 2004). Prothrombin overexpressed in post-natal neurones requires blood factors for activation in the mouse brain. Journal of Neurochemistry, 88 (6), 1380-8. doi:10.1046/j.1471-4159.2003.02268.x
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Ahmed, B. Y., Chakravarthy, S., Eggers, R., Hermens, W. T. J. M. C., Zhang, J. Y., NICLOU, S. P., Levelt, C., Sablitzky, F., Anderson, P. N., Lieberman, A. R., & Verhaagen, J. (30 January 2004). Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neuroscience, 5, 4. doi:10.1186/1471-2202-5-4
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NICLOU, S. P., Franssen, E. H. P., Ehlert, E. M. E., Taniguchi, M., & Verhaagen, J. (December 2003). Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth. Molecular and Cellular Neuroscience, 24 (4), 902-12. doi:10.1016/s1044-7431(03)00243-4
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Shearer, M. C., NICLOU, S. P., Brown, D., Asher, R. A., Holtmaat, A. J. G. D., Levine, J. M., Verhaagen, J., & Fawcett, J. W. (December 2003). The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Molecular and Cellular Neuroscience, 24 (4), 913-25. doi:10.1016/j.mcn.2003.09.004
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Ruitenberg, M. J., Plant, G. W., Christensen, C. L., Blits, B., NICLOU, S. P., Harvey, A. R., Boer, G. J., & Verhaagen, J. (January 2002). Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. Gene Therapy, 9 (2), 135-46. doi:10.1038/sj.gt.3301626
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NICLOU, S. P., Jia, L., & Raper, J. A. (01 July 2000). Slit2 is a repellent for retinal ganglion cell axons. Journal of Neuroscience, 20 (13), 4962-74. doi:10.1523/JNEUROSCI.20-13-04962.2000
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NICLOU, S. P., Suidan, H. S., Pavlik, A., Vejsada, R., & Monard, D. (May 1998). Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion. European Journal of Neuroscience, 10 (5), 1590-607. doi:10.1046/j.1460-9568.1998.00183.x
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Suidan, H. S., NICLOU, S. P., Dreessen, J., Beltraminelli, N., & Monard, D. (15 November 1996). The thrombin receptor is present in myoblasts and its expression is repressed upon fusion. Journal of Biological Chemistry, 271 (46), 29162-9. doi:10.1074/jbc.271.46.29162
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Suidan, H. S., Clemetson, K. J., Brown-Luedi, M., NICLOU, S. P., Clemetson, J. M., Tschopp, J., & Monard, D. (01 May 1996). The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin. Biochemical Journal, 315 ( Pt 3) (Pt 3), 939-45. doi:10.1042/bj3150939
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Suidan, H. S., NICLOU, S. P., & Monard, D. (1996). The thrombin receptor in the nervous system. Seminars in Thrombosis and Hemostasis, 22 (2), 125-33. doi:10.1055/s-2007-998999
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