tau Proteins; Humans; tau Proteins/metabolism; Inflammation; Brain/metabolism; Tauopathies; Brain; Neurology (clinical)
Precision for document type :
Review article
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Ising, Christina; Faculty of Medicine, Cluster of Excellence Cellular Stress Response in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany, University Hospital Cologne, Cluster of Excellence Cellular Stress Response in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; University of Bonn > Institute of Innate Immunity, Medical Faculty ; University of Massachusetts Medical School > Divison of Infectious Diseases and Immunology
External co-authors :
yes
Language :
English
Title :
Chronic inflammation: a potential target in tauopathies.
Langworth-Green, C, Patel, S, Jaunmuktane, Z, et al. Chronic effects of inflammation on tauopathies. Lancet Neurol 22 (2023), 430–442.
Ising, C, Venegas, C, Zhang, S, et al. NLRP3 inflammasome activation drives tau pathology. Nature 575 (2019), 669–673.
Maphis, N, Xu, G, Kokiko-Cochran, ON, et al. Loss of tau rescues inflammation-mediated neurodegeneration. Front Neurosci, 9, 2015, 196.
Wang, C, Fan, L, Khawaja, RR, et al. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun, 13, 2022, 1969.
Chen, G, Wu, D, Guo, W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 130 (2020), 2620–2629.
Heneka, MT, Kummer, MP, Stutz, A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493 (2013), 674–678.
Joly-Amado, A, Hunter, J, Quadri, Z, et al. CCL2 Overexpression in the brain promotes glial activation and accelerates tau pathology in a mouse model of tauopathy. Front Immunol, 11, 2020, 997.
Wu, T, Dejanovic, B, Gandham, VD, et al. Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy. Cell Rep 28 (2019), 2111–2123.
Gratuze, M, Schlachetzki, JCM, D'Oliveira Albanus, R, et al. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron 111 (2023), 202–219.
Bussian, TJ, Aziz, A, Meyer, CF, Swenson, BL, van Deursen, JM, Baker, DJ, Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562 (2018), 578–582.
Paolicelli, RC, Sierra, A, Stevens, B, et al. Microglia states and nomenclature: a field at its crossroads. Neuron 110 (2022), 3458–3483.
Kitazawa, M, Oddo, S, Yamasaki, TR, Green, KN, LaFerla, FM, Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25 (2005), 8843–8853.
Bhaskar, K, Konerth, M, Kokiko-Cochran, ON, Cardona, A, Ransohoff, RM, Lamb, BT, Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68 (2010), 19–31.
Krstic, D, Madhusudan, A, Doehner, J, et al. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation, 9, 2012, 151.
Torvell, M, Hampton, DW, Connick, P, MacLullich, AMJ, Cunningham, C, Chandran, S, A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy. Alzheimers Dement (N Y) 5 (2019), 579–591.
Sarlus, H, Höglund, CO, Karshikoff, B, et al. Allergy influences the inflammatory status of the brain and enhances tau-phosphorylation. J Cell Mol Med 16 (2012), 2401–2412.