No full text
Article (Scientific journals)
Regulation of superoxide production in neutrophils: role of calcium influx
Bréchard, Sabrina; Tschirhart, Eric
2008In Journal of Leukocyte Biology, 84 (5), p. 1223-1237
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] Upon stimulation, activation of NADPH oxidase complexes in neutrophils produces a burst of superoxide anions contributing to oxidative stress and the development of inflammatory process. Store-operated calcium entry (SOCE), whereby the depletion of intracellular stores induces extracellular calcium influx, is known to be a crucial element of NADPH oxidase regulation. However, the mechanistic basis mediating SOCE is still only partially understood, as is the signal-coupling pathway leading to modulation of store-operated channels. This review emphasizes the role of calcium influx in the control of the NADPH oxidase and summarizes the current knowledge of pathways mediating this extracellular calcium entry in neutrophils. Such investigations into the cross-talk between NADPH oxidase and calcium might allow the identification of novel pharmacological targets with clinical use, particularly in inflammatory diseases.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2013-031
Author, co-author :
Bréchard, Sabrina ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Tschirhart, Eric ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Regulation of superoxide production in neutrophils: role of calcium influx
Publication date :
2008
Journal title :
Journal of Leukocyte Biology
ISSN :
0741-5400
Publisher :
Wiley Liss, Inc., New York, United States - New York
Volume :
84
Issue :
5
Pages :
1223-1237
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 09 September 2013

Statistics


Number of views
69 (1 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
159
Scopus citations®
without self-citations
158
OpenCitations
 
142
WoS citations
 
155

Bibliography


Similar publications



Contact ORBilu