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TSCHIRHART Eric

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Health, Medicine and Life Sciences (DHML)

Main Referenced Co-authors
BUEB, Jean-Luc  (20)
BRECHARD, Sabrina  (15)
Landry, Y. (9)
MELCHIOR, Chantal  (9)
Bertrand, C. (8)
Main Referenced Keywords
pharmacology (25); drug effects (24); Animals (18); metabolism (18); physiology (14);
Main Referenced Unit & Research Centers
Life Sciences Research Unit (LSRU): Immune Cells and Inflammatory Diseases (ICID) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (52)
Computer science (5)
Space science, astronomy & astrophysics (1)

Publications (total 58)

The most downloaded
341 downloads
BRÉCHARD, S., PLANÇON, S., & TSCHIRHART, E. (2013). New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling. Antioxidants & Redox Signaling, 18 (6), 661-676. doi:10.1089/ars.2012.4773 https://hdl.handle.net/10993/8296

The most cited

282 citations (OpenAlex)

GUEGUINOU, N., HUIN-SCHOHN, C., Bascove, M., BUEB, J.-L., TSCHIRHART, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009). Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit? Journal of Leukocyte Biology, 86 (5), 1027-1038. doi:10.1189/jlb.0309167 https://hdl.handle.net/10993/5788

TSCHIRHART, E., GREVISSE, C., & CASTELLANOS, B. (2025). Empowering Education with an AI Learning Companion. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/66792.

TSCHIRHART, E., & GREVISSE, C. (03 December 2025). GenAI in Action: Getting hands on with Real-World Use Cases Across Education [Paper presentation]. OEB 2025 | Shaping the Future of Learning, Berlin, Germany.

TSCHIRHART, E. (08 October 2025). AI4Lecture | Leverage on AWS AI services for Higher Education teaching and learning [Paper presentation]. AWS Executive Study Tour | Advancing Research and Academic excellence through data and AI, London, United Kingdom.

TSCHIRHART, E. (11 June 2025). AI4Lecture, how to leverage on AWS AI services for Higher Education teaching and learning [Paper presentation]. TNC25 | GEANT, Brighton, United Kingdom.

TSCHIRHART, E. (16 April 2025). AI in action: accelerating public sector innovation [Paper presentation]. AWS Web Summit, Amsterdam, Netherlands.

Zenou, E., TSCHIRHART, E., & Elizaveta Shashkova. (2023). UNIVERSEH: PROPELLING EUROPE TO NEW HEIGHTS IN COMPREHENSIVE SPACE EDUCATION AND RESEARCH. Bruxelles, Belgium: Council of European Aerospace Societies.

Schenten, V., Plancon, S., JUNG, N., HANN, J., BUEB, J.-L., BRÉCHARD, S., TSCHIRHART, E., & TOLLE, F. (March 2018). Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9. Frontiers in Immunology, 9, 447. doi:10.3389/fimmu.2018.00447
Peer Reviewed verified by ORBi

NAEGELEN, I., BEAUME, N., PLANÇON, S., SCHENTEN, V., TSCHIRHART, E., & BRÉCHARD, S. (22 October 2015). Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting. Journal of Immunology Research, 2015, 1-15. doi:10.1155/2015/817038
Peer reviewed

NAEGELEN, I., PLANÇON, S., Nicot, N., Kaoma, T., Muller, A., Vallar, L., TSCHIRHART, E., & BRÉCHARD, S. (29 December 2014). An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells. Journal of Leukocyte Biology, 97. doi:10.1189/jlb.3A0514-254RR
Peer Reviewed verified by ORBi

BRÉCHARD, S., PLANÇON, S., & TSCHIRHART, E. (2013). New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling. Antioxidants & Redox Signaling, 18 (6), 661-676. doi:10.1089/ars.2012.4773
Peer reviewed

HUIN-SCHOHN, C., GUEGUINOU, N., SCHENTEN, V., Bascove, M., Koch, G. G., Baatout, S., TSCHIRHART, E., & Frippiat, J.-P. (2013). Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. FASEB Journal, 27 (1), 333-341. doi:10.1096/fj.12-217547
Peer Reviewed verified by ORBi

Faure, M. C., Sulpice, J.-C., Delattre, M., Lavielle, M., Prigent, M., Cuif, M.-H., MELCHIOR, C., TSCHIRHART, E., Nusse, O., & Dupre-Crochet, S. (2013). The recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent. Biology of the Cell. doi:10.1111/boc.201300010
Peer Reviewed verified by ORBi

BRÉCHARD, S., SCHENTEN, V., & TSCHIRHART, E. (2012). Role of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation. In M. Khatami (Ed.), Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (pp. 307-330). InTech. doi:10.5772/25976
Peer reviewed

GUEGUINOU, N., Bojados, M., Jamon, M., Derradji, H., Baatout, S., TSCHIRHART, E., Frippiat, J.-P., & Legrand-Frossi, C. (2012). Stress response and humoral immune system alterations related to chronic hypergravity in mice. Psychoneuroendocrinology, 37 (1), 137-147. doi:10.1016/j.psyneuen.2011.05.015
Peer Reviewed verified by ORBi

Steinckwich, N., SCHENTEN, V., MELCHIOR, C., BRÉCHARD, S., & TSCHIRHART, E. (2011). An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity. Journal of Immunology, 186 (4), 2182-2191. doi:10.4049/jimmunol.1001338
Peer Reviewed verified by ORBi

SCHENTEN, V., MELCHIOR, C., Steinckwich, N., TSCHIRHART, E., & BRÉCHARD, S. (2011). Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. Journal of Leukocyte Biology, 89 (4), 587-596. doi:10.1189/jlb.0510304
Peer Reviewed verified by ORBi

HEMMER, M., Kempen, I., de Tullio, P., Frankenne, F., Lambert, V., Blacher, S., BUEB, J.-L., Foidart, J.-M., Noël, A., TSCHIRHART, E., & Pirotte, B. (2010). New biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent. Drug Development Research, 71, 209-218. doi:10.1002/ddr.20364
Peer reviewed

SCHENTEN, V., BRÉCHARD, S., PLANÇON, S., MELCHIOR, C., Frippiat, J.-P., & TSCHIRHART, E. (2010). iPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity. Biochimica et Biophysica Acta-Molecular Cell Research, 1803 (7), 840-847. doi:10.1016/j.bbamcr.2010.02.006
Peer reviewed

TSCHIRHART, E. (2009). Les peptides opioïdes et autres médiateurs de la nociception. In Y. Landry & J.-P. Gies (Eds.), Pharmacologie. Des cibles vers l’indication thérapeutique (pp. 423-440). Paris, Unknown/unspecified: Dunod.
Peer reviewed

Bascove, M., HUIN-SCHOHN, C., GUEGUINOU, N., TSCHIRHART, E., & Frippiat, J.-P. (2009). Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl. FASEB Journal, 23 (5), 1607-1615. doi:10.1096/fj.08-121327
Peer Reviewed verified by ORBi

GUEGUINOU, N., HUIN-SCHOHN, C., Bascove, M., BUEB, J.-L., TSCHIRHART, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009). Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit? Journal of Leukocyte Biology, 86 (5), 1027-1038. doi:10.1189/jlb.0309167
Peer Reviewed verified by ORBi

BRÉCHARD, S., PLANÇON, S., MELCHIOR, C., & TSCHIRHART, E. (2009). STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells. Biochemical Pharmacology, 78 (5), 504-513. doi:10.1016/j.bcp.2009.05.006
Peer reviewed

BRÉCHARD, S., SALSMANN, A., & TSCHIRHART, E. (2009). OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry. Journal of Leukocyte Biology, 85 (4), 638-647. doi:10.1189/jlb.0508330
Peer Reviewed verified by ORBi

BERNARD, Y., PLANÇON, S., MELCHIOR, C., TSCHIRHART, E., & BUEB, J.-L. (2008). Cell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells. Journal of Cell and Animal Biology, 2 (9), 160-165.
Peer Reviewed verified by ORBi

BERNARD, Y., MELCHIOR, C., TSCHIRHART, E., & BUEB, J.-L. (2008). Co-cultures of Human Coronary Smooth Muscle Cells and Dimethyl Sulfoxide-differentiated HL60 Cells Upregulate ProMMP9 Activity and Promote Mobility"”Modulation By Reactive Oxygen Species. Inflammation, 1-2. doi:10.1007/s10753-008-9077-z
Peer Reviewed verified by ORBi

BRÉCHARD, S., MELCHIOR, C., PLANÇON, S., SCHENTEN, V., & TSCHIRHART, E. (2008). Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. Cell Calcium, 1-2. doi:10.1016/j.ceca.2008.03.002
Peer Reviewed verified by ORBi

SCHENTEN, V., BRÉCHARD, S., MELCHIOR, C., PLANÇON, S., SALSMANN, A., & TSCHIRHART, E. (2008). Ca2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes. Calcium Binding Proteins, 3 (1), 25-30.
Peer Reviewed verified by ORBi

BRÉCHARD, S., & TSCHIRHART, E. (2008). Regulation of superoxide production in neutrophils: role of calcium influx. Journal of Leukocyte Biology, 84 (5), 1223-1237. doi:10.1189/jlb.0807553
Peer Reviewed verified by ORBi

BRÉCHARD, S., Brunello, A., BUEB, J.-L., & TSCHIRHART, E. (2006). Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells. Biochimica et Biophysica Acta, 1763 (1), 129-36. doi:10.1016/j.bbamcr.2005.12.003
Peer reviewed

Otto, A., Fontaine, J., TSCHIRHART, E., Fontaine, D., & Berkenboom, G. (2006). Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway. British Journal of Pharmacology, 148 (4), 544-52. doi:10.1038/sj.bjp.0706738
Peer Reviewed verified by ORBi

Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., Descotes, J., Hartung, T., Hooghe-Peters, R., House, R., Pallardy, M., Pieters, R., Reid, L., Tryphonas, H., TSCHIRHART, E., Tuschl, H., Vandebriel, R., & Gribaldo, L. (2005). The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop. Journal of Immunotoxicology, 2 (2), 61-83. doi:10.1080/15476910590965832
Peer reviewed

BRÉCHARD, S., BUEB, J.-L., & TSCHIRHART, E. (2005). Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium. Cell Calcium, 37 (6), 531-40. doi:10.1016/j.ceca.2005.01.019
Peer Reviewed verified by ORBi

Valentin, F., BUEB, J.-L., Kieffer, P., TSCHIRHART, E., & Atkinson, J. (2005). Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells. Fundamental and Clinical Pharmacology, 19 (6), 661-7. doi:10.1111/j.1472-8206.2005.00371.x
Peer Reviewed verified by ORBi

Zardini, D. M., & TSCHIRHART, E. (2001). Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide. Inflammation Research, 50 (7), 357-61. doi:10.1007/PL00000256
Peer Reviewed verified by ORBi

Petitcolin, M. A., Vandeputte, C., Spitzbarth-Régrigny, E., BUEB, J.-L., Capdeville-Atkinson, C., & TSCHIRHART, E. (2001). Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle. Biochemical Pharmacology, 61 (4), 485-91. doi:10.1016/S0006-2952(00)00547-5
Peer reviewed

Petitcolin, M. A., Spitzbarth-Régrigny, E., BUEB, J.-L., Capdeville-Atkinson, C., & TSCHIRHART, E. (2001). Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle. Biochemical Pharmacology, 61 (9), 1169-75. doi:10.1016/S0006-2952(01)00589-5
Peer reviewed

Valentin, F., BUEB, J.-L., Capdeville-Atkinson, C., & TSCHIRHART, E. (2001). Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells. Cell Calcium, 29 (6), 409-15. doi:10.1054/ceca.2001.0203
Peer Reviewed verified by ORBi

BUEB, J.-L., Lambert, D. M., & TSCHIRHART, E. (2001). Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. Biochimica et Biophysica Acta, 1538 (2-3), 252-9. doi:10.1016/S0167-4889(01)00076-3
Peer reviewed

Spitzbarth-Régrigny, E., Petitcolin, M. A., BUEB, J.-L., TSCHIRHART, E., Atkinson, J., & Capdeville-Atkinson, C. (2000). Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery. British Journal of Pharmacology, 131 (7), 1337-44. doi:10.1038/sj.bjp.0703703
Peer Reviewed verified by ORBi

Lambert, D. M., DiPaolo, F. G., Sonveaux, P., Kanyonyo, M., Govaerts, S. J., Hermans, E., BUEB, J.-L., Delzenne, N. M., & TSCHIRHART, E. (1999). Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors. Biochimica et Biophysica Acta, 1440 (2-3), 266-74. doi:10.1016/S1388-1981(99)00132-8
Peer reviewed

Zardini, D. M., & TSCHIRHART, E. (1999). Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion. Thérapie, 54 (1), 103-9.
Peer Reviewed verified by ORBi

Zardini, D. M., BUEB, J.-L., & TSCHIRHART, E. (1999). Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. Cell Calcium, 25 (5), 381-9. doi:10.1054/ceca.1999.0040
Peer Reviewed verified by ORBi

Gallois, A., BUEB, J.-L., & TSCHIRHART, E. (1999). Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells. European Journal of Pharmacology, 361 (2-3), 293-8. doi:10.1016/S0014-2999(98)00728-6
Peer Reviewed verified by ORBi

Zardini, D. M., HEUSCHLING, P., Gallois, A., BUEB, J.-L., & TSCHIRHART, E. (1997). Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production. Journal of Immunological Methods, 205 (1), 1-9. doi:10.1016/S0022-1759(97)00055-0
Peer reviewed

Gallois, A., BUEB, J.-L., & TSCHIRHART, E. (1996). Endothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells. Fundamental and Clinical Pharmacology, 10 (1), 28-32. doi:10.1111/j.1472-8206.1996.tb00146.x
Peer Reviewed verified by ORBi

BUEB, J.-L., Gallois, A., Schneider, J. C., Parini, J. P., & TSCHIRHART, E. (1995). A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages. Biochimica et Biophysica Acta, 1244 (1), 79-84.
Peer reviewed

Bertrand, C., Da Silva, A., Landry, Y., Theodorsson, E., & TSCHIRHART, E. (1993). An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea. Pulmonary Pharmacology, 6 (1), 69-76. doi:10.1006/pulp.1993.1010
Peer Reviewed verified by ORBi

Bertrand, C., & TSCHIRHART, E. (1993). Epithelial factors: modulation of the airway smooth muscle tone. Fundamental and Clinical Pharmacology, 7 (6), 261-73. doi:10.1111/j.1472-8206.1993.tb00240.x
Peer Reviewed verified by ORBi

Bertrand, C., TSCHIRHART, E., & Landry, Y. (1992). Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis. Immunopharmacology, 22 (2), 115-25. doi:10.1016/0162-3109(91)90036-X
Peer Reviewed verified by ORBi

TSCHIRHART, E., Pelton, J. T., & Jones, C. R. (1991). Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21). Agents and Actions. Supplements, 31, 233-6.
Peer reviewed

TSCHIRHART, E., Drijfhout, J. W., Pelton, J. T., Miller, R. C., & Jones, C. R. (1991). Endothelins: functional and autoradiographic studies in guinea pig trachea. Journal of Pharmacology and Experimental Therapeutics, 258 (1), 381-7.
Peer Reviewed verified by ORBi

Bertrand, C., TSCHIRHART, E., & Landry, Y. (1991). Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models. Agents and Actions. Supplements, 31, 247-50.

TSCHIRHART, E., Bertrand, C., Theodorsson, E., & Landry, Y. (1990). Evidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin. Naunyn-Schmiedeberg's Archives of Pharmacology, 342 (2), 177-81. doi:10.1007/BF00166961
Peer Reviewed verified by ORBi

Mousli, M., Bronner, C., BUEB, J.-L., TSCHIRHART, E., Gies, J. P., & Landry, Y. (1989). Activation of rat peritoneal mast cells by substance P and mastoparan. Journal of Pharmacology and Experimental Therapeutics, 250 (1), 329-35.
Peer Reviewed verified by ORBi

TSCHIRHART, E., Schmitt, P., Bertrand, C., Mayer, M., Magneney, S., Landry, Y., & Michelot, R. (1989). Contractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal. Naunyn-Schmiedeberg's Archives of Pharmacology, 340 (1), 107-10. doi:10.1007/BF00169215
Peer Reviewed verified by ORBi

Bertrand, C., TSCHIRHART, E., & Landry, Y. (1989). Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea. International Archives of Allergy and Applied Immunology, 88 (4), 439-46. doi:10.1159/000234730
Peer Reviewed verified by ORBi

TSCHIRHART, E., Frossard, N., Bertrand, C., & Landry, Y. (1987). Arachidonic acid metabolites and airway epithelium-dependent relaxant factor. Journal of Pharmacology and Experimental Therapeutics, 243 (1), 310-6.
Peer Reviewed verified by ORBi

TSCHIRHART, E., & Landry, Y. (1987). Airway epithelium releases a relaxant factor: demonstration with substance P. European Journal of Pharmacology, 132 (1), 103-4. doi:10.1016/0014-2999(86)90020-8
Peer Reviewed verified by ORBi

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