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TSCHIRHART Eric

University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)

Main Referenced Co-authors
BUEB, Jean-Luc  (20)
BRECHARD, Sabrina  (15)
Landry, Y. (9)
MELCHIOR, Chantal  (9)
Bertrand, C. (8)
Main Referenced Keywords
pharmacology (25); drug effects (24); Animals (18); metabolism (18); physiology (14);
Main Referenced Unit & Research Centers
Life Sciences Research Unit (LSRU): Immune Cells and Inflammatory Diseases (ICID) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (52)
Space science, astronomy & astrophysics (1)

Publications (total 53)

The most downloaded
265 downloads
Bréchard, S., Plançon, S., & Tschirhart, E. (2013). New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling. Antioxidants & Redox Signaling, 18 (6), 661-676. doi:10.1089/ars.2012.4773 https://hdl.handle.net/10993/8296

The most cited

228 citations (Scopus®)

Gueguinou, N., Huin-Schohn, C., Bascove, M., Bueb, J.-L., Tschirhart, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009). Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit? Journal of Leukocyte Biology, 86 (5), 1027-1038. doi:10.1189/jlb.0309167 https://hdl.handle.net/10993/5788

Zenou, E., TSCHIRHART, E., & Elizaveta Shashkova. (2023). UNIVERSEH: PROPELLING EUROPE TO NEW HEIGHTS IN COMPREHENSIVE SPACE EDUCATION AND RESEARCH. Bruxelles, Belgium: Council of European Aerospace Societies.

Schenten, V., Plancon, S., Jung, N., Hann, J., Bueb, J.-L., Bréchard, S., Tschirhart, E., & Tolle, F. (March 2018). Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9. Frontiers in Immunology, 9, 447. doi:10.3389/fimmu.2018.00447
Peer Reviewed verified by ORBi

Naegelen, I., Beaume, N., Plançon, S., Schenten, V., Tschirhart, E., & Bréchard, S. (22 October 2015). Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting. Journal of Immunology Research, 2015, 1-15. doi:10.1155/2015/817038
Peer reviewed

Naegelen, I., Plançon, S., Nicot, N., Kaoma, T., Muller, A., Vallar, L., Tschirhart, E., & Bréchard, S. (29 December 2014). An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells. Journal of Leukocyte Biology, 97. doi:10.1189/jlb.3A0514-254RR
Peer Reviewed verified by ORBi

Huin-Schohn, C., Gueguinou, N., Schenten, V., Bascove, M., Koch, G. G., Baatout, S., Tschirhart, E., & Frippiat, J.-P. (2013). Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. FASEB Journal, 27 (1), 333-341. doi:10.1096/fj.12-217547
Peer Reviewed verified by ORBi

Bréchard, S., Plançon, S., & Tschirhart, E. (2013). New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling. Antioxidants & Redox Signaling, 18 (6), 661-676. doi:10.1089/ars.2012.4773
Peer reviewed

Faure, M. C., Sulpice, J.-C., Delattre, M., Lavielle, M., Prigent, M., Cuif, M.-H., Melchior, C., Tschirhart, E., Nusse, O., & Dupre-Crochet, S. (2013). The recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent. Biology of the Cell. doi:10.1111/boc.201300010
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Gueguinou, N., Bojados, M., Jamon, M., Derradji, H., Baatout, S., Tschirhart, E., Frippiat, J.-P., & Legrand-Frossi, C. (2012). Stress response and humoral immune system alterations related to chronic hypergravity in mice. Psychoneuroendocrinology, 37 (1), 137-147. doi:10.1016/j.psyneuen.2011.05.015
Peer Reviewed verified by ORBi

Bréchard, S., Schenten, V., & Tschirhart, E. (2012). Role of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation. In M. Khatami (Ed.), Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (pp. 307-330). InTech. doi:10.5772/25976
Peer reviewed

Steinckwich, N., Schenten, V., Melchior, C., Bréchard, S., & Tschirhart, E. (2011). An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity. Journal of Immunology, 186 (4), 2182-2191. doi:10.4049/jimmunol.1001338
Peer Reviewed verified by ORBi

Schenten, V., Melchior, C., Steinckwich, N., Tschirhart, E., & Bréchard, S. (2011). Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. Journal of Leukocyte Biology, 89 (4), 587-596. doi:10.1189/jlb.0510304
Peer Reviewed verified by ORBi

Schenten, V., Bréchard, S., Plançon, S., Melchior, C., Frippiat, J.-P., & Tschirhart, E. (2010). iPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity. Biochimica et Biophysica Acta-Molecular Cell Research, 1803 (7), 840-847. doi:10.1016/j.bbamcr.2010.02.006
Peer reviewed

Hemmer, M., Kempen, I., de Tullio, P., Frankenne, F., Lambert, V., Blacher, S., Bueb, J.-L., Foidart, J.-M., Noël, A., Tschirhart, E., & Pirotte, B. (2010). New biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent. Drug Development Research, 71, 209-218. doi:10.1002/ddr.20364
Peer reviewed

Bréchard, S., Plançon, S., Melchior, C., & Tschirhart, E. (2009). STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells. Biochemical Pharmacology, 78 (5), 504-513. doi:10.1016/j.bcp.2009.05.006
Peer reviewed

Bréchard, S., Salsmann, A., & Tschirhart, E. (2009). OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry. Journal of Leukocyte Biology, 85 (4), 638-647. doi:10.1189/jlb.0508330
Peer Reviewed verified by ORBi

Gueguinou, N., Huin-Schohn, C., Bascove, M., Bueb, J.-L., Tschirhart, E., Legrand-Frossi, C., & Frippiat, J.-P. (2009). Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit? Journal of Leukocyte Biology, 86 (5), 1027-1038. doi:10.1189/jlb.0309167
Peer Reviewed verified by ORBi

Bascove, M., Huin-Schohn, C., Gueguinou, N., Tschirhart, E., & Frippiat, J.-P. (2009). Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl. FASEB Journal, 23 (5), 1607-1615. doi:10.1096/fj.08-121327
Peer Reviewed verified by ORBi

Tschirhart, E. (2009). Les peptides opioïdes et autres médiateurs de la nociception. In Y. Landry & J.-P. Gies (Eds.), Pharmacologie. Des cibles vers l’indication thérapeutique (pp. 423-440). Paris, Unknown/unspecified: Dunod.
Peer reviewed

Bréchard, S., Melchior, C., Plançon, S., Schenten, V., & Tschirhart, E. (2008). Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. Cell Calcium, 1-2. doi:10.1016/j.ceca.2008.03.002
Peer Reviewed verified by ORBi

Schenten, V., Bréchard, S., Melchior, C., Plançon, S., Salsmann, A., & Tschirhart, E. (2008). Ca2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes. Calcium Binding Proteins, 3 (1), 25-30.
Peer Reviewed verified by ORBi

Bréchard, S., & Tschirhart, E. (2008). Regulation of superoxide production in neutrophils: role of calcium influx. Journal of Leukocyte Biology, 84 (5), 1223-1237. doi:10.1189/jlb.0807553
Peer Reviewed verified by ORBi

Bernard, Y., Melchior, C., Tschirhart, E., & Bueb, J.-L. (2008). Co-cultures of Human Coronary Smooth Muscle Cells and Dimethyl Sulfoxide-differentiated HL60 Cells Upregulate ProMMP9 Activity and Promote Mobility"”Modulation By Reactive Oxygen Species. Inflammation, 1-2. doi:10.1007/s10753-008-9077-z
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Bernard, Y., Plançon, S., Melchior, C., Tschirhart, E., & Bueb, J.-L. (2008). Cell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells. Journal of Cell and Animal Biology, 2 (9), 160-165.
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Otto, A., Fontaine, J., Tschirhart, E., Fontaine, D., & Berkenboom, G. (2006). Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway. British Journal of Pharmacology, 148 (4), 544-52. doi:10.1038/sj.bjp.0706738
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Bréchard, S., Brunello, A., Bueb, J.-L., & Tschirhart, E. (2006). Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells. Biochimica et Biophysica Acta, 1763 (1), 129-36. doi:10.1016/j.bbamcr.2005.12.003
Peer reviewed

Bréchard, S., Bueb, J.-L., & Tschirhart, E. (2005). Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium. Cell Calcium, 37 (6), 531-40. doi:10.1016/j.ceca.2005.01.019
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Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., Descotes, J., Hartung, T., Hooghe-Peters, R., House, R., Pallardy, M., Pieters, R., Reid, L., Tryphonas, H., Tschirhart, E., Tuschl, H., Vandebriel, R., & Gribaldo, L. (2005). The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop. Journal of Immunotoxicology, 2 (2), 61-83. doi:10.1080/15476910590965832
Peer reviewed

Valentin, F., Bueb, J.-L., Kieffer, P., Tschirhart, E., & Atkinson, J. (2005). Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells. Fundamental and Clinical Pharmacology, 19 (6), 661-7. doi:10.1111/j.1472-8206.2005.00371.x
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Zardini, D. M., & Tschirhart, E. (2001). Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide. Inflammation Research, 50 (7), 357-61. doi:10.1007/PL00000256
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Petitcolin, M. A., Spitzbarth-Régrigny, E., Bueb, J.-L., Capdeville-Atkinson, C., & Tschirhart, E. (2001). Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle. Biochemical Pharmacology, 61 (9), 1169-75. doi:10.1016/S0006-2952(01)00589-5
Peer reviewed

Bueb, J.-L., Lambert, D. M., & Tschirhart, E. (2001). Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro. Biochimica et Biophysica Acta, 1538 (2-3), 252-9. doi:10.1016/S0167-4889(01)00076-3
Peer reviewed

Valentin, F., Bueb, J.-L., Capdeville-Atkinson, C., & Tschirhart, E. (2001). Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells. Cell Calcium, 29 (6), 409-15. doi:10.1054/ceca.2001.0203
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Petitcolin, M. A., Vandeputte, C., Spitzbarth-Régrigny, E., Bueb, J.-L., Capdeville-Atkinson, C., & Tschirhart, E. (2001). Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle. Biochemical Pharmacology, 61 (4), 485-91. doi:10.1016/S0006-2952(00)00547-5
Peer reviewed

Spitzbarth-Régrigny, E., Petitcolin, M. A., Bueb, J.-L., Tschirhart, E., Atkinson, J., & Capdeville-Atkinson, C. (2000). Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery. British Journal of Pharmacology, 131 (7), 1337-44. doi:10.1038/sj.bjp.0703703
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Lambert, D. M., DiPaolo, F. G., Sonveaux, P., Kanyonyo, M., Govaerts, S. J., Hermans, E., Bueb, J.-L., Delzenne, N. M., & Tschirhart, E. (1999). Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors. Biochimica et Biophysica Acta, 1440 (2-3), 266-74. doi:10.1016/S1388-1981(99)00132-8
Peer reviewed

Zardini, D. M., & Tschirhart, E. (1999). Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion. Thérapie, 54 (1), 103-9.
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Zardini, D. M., Bueb, J.-L., & Tschirhart, E. (1999). Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. Cell Calcium, 25 (5), 381-9. doi:10.1054/ceca.1999.0040
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Gallois, A., Bueb, J.-L., & Tschirhart, E. (1999). Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells. European Journal of Pharmacology, 361 (2-3), 293-8. doi:10.1016/S0014-2999(98)00728-6
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Zardini, D. M., Heuschling, P., Gallois, A., Bueb, J.-L., & Tschirhart, E. (1997). Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production. Journal of Immunological Methods, 205 (1), 1-9. doi:10.1016/S0022-1759(97)00055-0
Peer reviewed

Gallois, A., Bueb, J.-L., & Tschirhart, E. (1996). Endothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells. Fundamental and Clinical Pharmacology, 10 (1), 28-32. doi:10.1111/j.1472-8206.1996.tb00146.x
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Bueb, J.-L., Gallois, A., Schneider, J. C., Parini, J. P., & Tschirhart, E. (1995). A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages. Biochimica et Biophysica Acta, 1244 (1), 79-84.
Peer reviewed

Bertrand, C., Da Silva, A., Landry, Y., Theodorsson, E., & Tschirhart, E. (1993). An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea. Pulmonary Pharmacology, 6 (1), 69-76. doi:10.1006/pulp.1993.1010
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Bertrand, C., & Tschirhart, E. (1993). Epithelial factors: modulation of the airway smooth muscle tone. Fundamental and Clinical Pharmacology, 7 (6), 261-73. doi:10.1111/j.1472-8206.1993.tb00240.x
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Bertrand, C., Tschirhart, E., & Landry, Y. (1992). Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis. Immunopharmacology, 22 (2), 115-25. doi:10.1016/0162-3109(91)90036-X
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Tschirhart, E., Drijfhout, J. W., Pelton, J. T., Miller, R. C., & Jones, C. R. (1991). Endothelins: functional and autoradiographic studies in guinea pig trachea. Journal of Pharmacology and Experimental Therapeutics, 258 (1), 381-7.
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Tschirhart, E., Pelton, J. T., & Jones, C. R. (1991). Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21). Agents and Actions. Supplements, 31, 233-6.
Peer reviewed

Bertrand, C., Tschirhart, E., & Landry, Y. (1991). Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models. Agents and Actions. Supplements, 31, 247-50.

Tschirhart, E., Bertrand, C., Theodorsson, E., & Landry, Y. (1990). Evidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin. Naunyn-Schmiedeberg's Archives of Pharmacology, 342 (2), 177-81. doi:10.1007/BF00166961
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Mousli, M., Bronner, C., Bueb, J.-L., Tschirhart, E., Gies, J. P., & Landry, Y. (1989). Activation of rat peritoneal mast cells by substance P and mastoparan. Journal of Pharmacology and Experimental Therapeutics, 250 (1), 329-35.
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Tschirhart, E., Schmitt, P., Bertrand, C., Mayer, M., Magneney, S., Landry, Y., & Michelot, R. (1989). Contractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal. Naunyn-Schmiedeberg's Archives of Pharmacology, 340 (1), 107-10. doi:10.1007/BF00169215
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Bertrand, C., Tschirhart, E., & Landry, Y. (1989). Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea. International Archives of Allergy and Applied Immunology, 88 (4), 439-46. doi:10.1159/000234730
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Tschirhart, E., Frossard, N., Bertrand, C., & Landry, Y. (1987). Arachidonic acid metabolites and airway epithelium-dependent relaxant factor. Journal of Pharmacology and Experimental Therapeutics, 243 (1), 310-6.
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Tschirhart, E., & Landry, Y. (1987). Airway epithelium releases a relaxant factor: demonstration with substance P. European Journal of Pharmacology, 132 (1), 103-4. doi:10.1016/0014-2999(86)90020-8
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