HLA; Lewy bodie dementia; REM sleep behavior disorder
Abstract :
[en] Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95 CI = 1.27–1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95\%CI = 1.12–1.41, p = 8.76e-05), 70Q (OR = 0.81, 95\%CI = 0.72–0.91, p = 3.65e-04) and 71R (OR = 1.21, 95\%CI = 1.08–1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) LIH - Luxembourg Institute of Health
Disciplines :
Neurology Genetics & genetic processes
Author, co-author :
Yu, Eric
Krohn, Lynne
Ruskey, Jennifer A.
Asayesh, Farnaz
Spiegelman, Dan
Shah, Zalak
Chia, Ruth
Arnulf, Isabelle
Hu, Michele T. M.
Montplaisir, Jacques Y.
Gagnon, Jean-François
Desautels, Alex
Dauvilliers, Yves
Gigli, Gian Luigi
Valente, Mariarosaria
Janes, Francesco
Bernardini, Andrea
Högl, Birgit
Stefani, Ambra
Ibrahim, Abubaker
Heidbreder, Anna
Sonka, Karel
Dusek, Petr
Kemlink, David
Oertel, Wolfgang
Janzen, Annette
Plazzi, Giuseppe
Antelmi, Elena
Figorilli, Michela
Puligheddu, Monica
Mollenhauer, Brit
Trenkwalder, Claudia
Sixel-Döring, Friederike
Cochen De Cock, Valérie
Ferini-Strambi, Luigi
Dijkstra, Femke
Viaene, Mineke
Abril, Beatriz
Boeve, Bradley F.
Rouleau, Guy A.
Postuma, Ronald B.
MAY, Patrick ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
KRÜGER, Rejko ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
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