bladder cancer; urology; drug discovery; drug repurposing; data driven
Abstract :
[en] Delivering better care for patients with bladder cancer (BC) necessitates the development of novel therapeutic strategies that address both the high disease heterogeneity and the limitations of the current therapeutic modalities, such as drug low efficacy and patient resistance acquisition. Drug repurposing is a cost-effective strategy that targets the reuse of existing drugs for new therapeutic purposes. Such a strategy could open new avenues toward more effective BC treatment. BC patients' multi-omics signatures can be used to guide the investigation of existing drugs that show an effective therapeutic potential through drug repurposing. In this book chapter, we present an integrated multilayer approach that includes cross-omics analyses from publicly available transcriptomics and proteomics data derived from BC tissues and cell lines that were investigated for the development of disease-specific signatures. These signatures are subsequently used as input for a signature-based repurposing approach using the Connectivity Map (CMap) tool. We further explain the steps that may be followed to identify and select existing drugs of increased potential for repurposing in BC patients.
Research center :
Mosaiques Diagnostics
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Mokou, Marika ✱; Mosaiques Diagnostics > Department of Biomarker Research
NARAYANASAMY, Shaman ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Stroggilos, Rafael; Academy of Athens > Systems Biology Center
BALAUR, Irina-Afrodita ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Vlahou, Antonia; Academy of Athens > Systems Biology Center
Mischak, Harald; Mosaiques Diagnostics > Department of Biomarker Research
Frantzi, Maria; Mosaiques Diagnostics > Department of Biomarker Research
✱ These authors have contributed equally to this work.
External co-authors :
yes
Language :
English
Title :
A Drug Repurposing Pipeline Based on Bladder Cancer Integrated Proteotranscriptomics Signatures
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