Article (Scientific journals)
Expanding the Disease Network of Glioblastoma Multiforme via Topological Analysis.
Badkas, Apurva; de Landtsheer, Sébastien; Sauter, Thomas
2023In International Journal of Molecular Sciences, 24 (4)
Peer reviewed
 

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Keywords :
Humans; Glioblastoma/metabolism; Brain Neoplasms/metabolism; Glioma/genetics; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; betweenness centrality; glioblastoma; network analysis; topology
Abstract :
[en] Glioblastoma multiforme (GBM), a grade IV glioma, is a challenging disease for patients and clinicians, with an extremely poor prognosis. These tumours manifest a high molecular heterogeneity, with limited therapeutic options for patients. Since GBM is a rare disease, sufficient statistically strong evidence is often not available to explore the roles of lesser-known GBM proteins. We present a network-based approach using centrality measures to explore some key, topologically strategic proteins for the analysis of GBM. Since network-based analyses are sensitive to changes in network topology, we analysed nine different GBM networks, and show that small but well-curated networks consistently highlight a set of proteins, indicating their likely involvement in the disease. We propose 18 novel candidates which, based on differential expression, mutation analysis, and survival analysis, indicate that they may play a role in GBM progression. These should be investigated further for their functional roles in GBM, their clinical prognostic relevance, and their potential as therapeutic targets.
Research center :
ULHPC - University of Luxembourg: High Performance Computing
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Badkas, Apurva ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
de Landtsheer, Sébastien ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Sauter, Thomas ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
External co-authors :
no
Language :
English
Title :
Expanding the Disease Network of Glioblastoma Multiforme via Topological Analysis.
Publication date :
2023
Journal title :
International Journal of Molecular Sciences
ISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
24
Issue :
4
Peer reviewed :
Peer reviewed
Focus Area :
Systems Biomedicine
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since 10 March 2023

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