Reference : Mechano-self-regulation of bacterial size in growing colonies

	Document type :	E-prints/Working papers : Already available on another site
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Physics
	Focus Areas :	Physics and Materials Science
	To cite this reference:	http://hdl.handle.net/10993/53309

Title :	Mechano-self-regulation of bacterial size in growing colonies
Language :	English
Author, co-author :	Wittmann, René []
	Nguyen, G. H. Philipp []
	Löwen, Hartmut []
	Sengupta, Anupam [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
	Schwarzendahl, Fabian J. []
Publication date :	21-Dec-2022
Number of pages :	22
Peer reviewed :	No
Keywords :	[en] microbial active matter ; self-regulation ; growth ; feedback
Abstract :	[en] We demonstrate that biomechanical forcing plays an important role as the driving force behind the dynamical self-regulation of cell size (or length) in growing bacterial colonies. In our experiments, the measured elongation rate decreases over time and depends on the areal packing density around each cell. To describe this phenomenon theoretically, we devise a cell-resolved model which includes as its key ingredient a force opposed to the growth process, accounting for mechano-self-regulation. Our model is analyzed analytically by a coarse-grained dynamical density functional theory and solved by cell-based computer simulations to predict how the strength of mechano-self-regulation depends on the bacterial size, the location in the colony and the local environment. The microscopic nature of this approach allows to quantify the effect of biomechanical interactions on the structure, composition and dynamical features of growing bacterial colonies.
Funders :	Fonds National de la Recherche - FnR
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/10993/53309
DOI :	10.48550/arXiv.2212.10101
Other URL :	https://doi.org/10.48550/arXiv.2212.10101
Mentions required by the publisher for OA :	CC-BY
source URL :	https://arxiv.org/abs/2212.10101
FnR project :	FnR ; FNR11572821 > Anupam Sengupta > MBRACE > Biophysics Of Microbial Adaptation To Fluctuations In The Environment > 15/05/2018 > 14/05/2023 > 2017

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