Malignant transformation; Low Grade Glioma; Low Grade Astrocytoma; Medical Resonance Imaging; Patient-specific Tumor Growth Model
Abstract :
[en] Grade 3 and 4 Astrocytomas are high grade gliomas (HGG) that usually result from initially less aggressive low grade gliomas (LGG) through malignant transformation (MT). This process has various definitions in the literature, clinical and histopathological, depending on the scale of the study and researchers' interest. We introduce an overview of different aspects of MT: molecular, clinical and the role of the microenvironment in acquiring the malignant phenotype. Furthermore, we introduce a new hypothesis that could explain the spatial progression of low grade astrocytoma (LGA) during MT. The former hypothesis will next be tested on LGA patients through tumor segmentation from Medical Resonance Images (MRI) and a mechanistic growth model.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Abbad Andaloussi, Meryem ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Interventional Neuroscience
Husch, Andreas ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Interventional Neuroscience
Urcun, Stephane ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Engineering (DoE)
Bordas, Stéphane ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Engineering (DoE)