SYSTEMS METHODS FOR ANALYSIS OF HETEROGENEOUS GLIOBLASTOMA DATASETS TOWARDS ELUCIDATION OF INTER-TUMOURAL RESISTANCE PATHWAYS AND NEW THERAPEUTIC TARGETS

Tching Chi Yen, Romain Mana Hiao Woun

Reference : SYSTEMS METHODS FOR ANALYSIS OF HETEROGENEOUS GLIOBLASTOMA DATASETS TOWARDS ELUCIDATI...


	Document type :	Dissertations and theses : Doctoral thesis
	Discipline(s) :	Life sciences : Genetics & genetic processes Human health sciences : Neurology Human health sciences : Oncology Human health sciences : Multidisciplinary, general & others
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/52154

Title :	SYSTEMS METHODS FOR ANALYSIS OF HETEROGENEOUS GLIOBLASTOMA DATASETS TOWARDS ELUCIDATION OF INTER-TUMOURAL RESISTANCE PATHWAYS AND NEW THERAPEUTIC TARGETS
Language :	English
Author, co-author :	Tching Chi Yen, Romain Mana Hiao Woun [University of Luxembourg > Faculty of Science, Technology and Medecine (FSTM) > > ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core > ; Information Technologies for Translational Medicine]
Publication date :	6-May-2022
Institution :	University of Luxembourg, Luxembourg
Name of the degree :	Docteur en Biologie
Number of pages :	152 + 47
Supervisor :	Schneider, Reinhard
President of the jury :	Schymanski, Emma
Member of the jury :	Glaab, Enrico
	Niclou, Simone
Keywords :	[en] Glioblastoma ; Resistance Mechanisms ; Integrative analysis ; Multi-omics ; Data Management ; Molecular network ; Disease Map
Abstract :	[en] In this PhD thesis is described an endeavour to compile litterature about Glioblastoma key molecular mechanisms into a directed network followin Disease Maps standards, analyse its topology and compare results with quantitative analysis of multi-omics datasets in order to investigate Glioblastoma resistance mechanisms. The work also integrated implementation of Data Management good practices and procedures.
Name of the research project :	GLIOTRAIN - Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics
Target :	Researchers ; Students ; General public
Permalink :	http://hdl.handle.net/10993/52154
Commentary :	This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 766069.
Framework Programme / European Project :	H2020 ; 766069 - GLIOTRAIN - Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics

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Open access	RomainTCHING_thesis_finalVersion.pdf		Author postprint	3.25 MB	View/Open

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