Reference : Self-regulation of phenotypic noise synchronizes emergent organization and active tra...

	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Physics
	Focus Areas :	Physics and Materials Science
	To cite this reference:	http://hdl.handle.net/10993/51986

Title :	Self-regulation of phenotypic noise synchronizes emergent organization and active transport in confluent microbial environments
Language :	English
Author, co-author :	Dhar, Jayabrata [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
	Thai, Le Phuong Anh [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
	Ghoshal, Arkajyoti [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
	Giomi, Luca [University of Leiden, the Netherlands]
	Sengupta, Anupam [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
Publication date :	4-Jul-2022
Journal title :	Nature Physics
Publisher :	Nature Publishing Group
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	1745-2473
e-ISSN :	1745-2481
City :	London
Country :	United Kingdom
Keywords :	[en] biofilms ; self-organization ; phenotypic noise ; active transport ; topological defects ; synchrony
Abstract :	[en] The variation associated with different observable characteristics—phenotypes—at the cellular scale underpins homeostasis and the fitness of living systems. However, if and how these noisy phenotypic traits shape properties at the population level remains poorly understood. Here we report that phenotypic noise self-regulates with growth and coordinates collective structural organization, the kinetics of topological defects and the emergence of active transport around confluent colonies. We do this by cataloguing key phenotypic traits in bacteria growing under diverse conditions. Our results reveal a statistically precise critical time for the transition from a monolayer biofilm to a multilayer biofilm, despite the strong noise in the cell geometry and the colony area at the onset of the transition. This reveals a mitigation mechanism between the noise in the cell geometry and the growth rate that dictates the narrow critical time window. By uncovering how rectification of phenotypic noise homogenizes correlated collective properties across colonies, our work points at an emergent strategy that confluent systems employ to tune active transport, buffering inherent heterogeneities associated with natural cellular environment settings.
Funders :	Fonds National de la Recherche - FnR ; International Human Frontier Science Program Organization (HFSPO) ; Netherlands Organization for Scientific Research (NWO/OCW) ; ERC-CoG grant HexaTissue
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/10993/51986
DOI :	10.1038/s41567-022-01641-9
Other URL :	https://www.nature.com/articles/s41567-022-01641-9
FnR project :	FnR ; FNR11572821 > Anupam Sengupta > MBRACE > Biophysics Of Microbial Adaptation To Fluctuations In The Environment > 15/05/2018 > 14/05/2023 > 2017

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	Fulltext file(s): File Commentary Version Size Access Open access Sengupta-NaturePhysics2022.pdf Publisher postprint 2.87 MB View/Open Additional material(s): File Commentary Size Access Open access Sengupta-NaturePhysics2022-SupplementaryFile.pdf Supplementary Text and Information 11.77 MB View/Open

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