[en] While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudinal cohort of 63 mild and 15 hospitalized patients versus 14 asymptomatic and 26 household controls. We observe a transient increase of IP10/CXCL10 and interferon-β levels, coordinated responses of dominant SARS-CoV-2-specific CD4 and fewer CD8 T cells, and various antigen-presenting and antibody-secreting cells in mild patients within 3 days of PCR diagnosis. The frequency of key innate immune cells and their functional marker expression are impaired in hospitalized patients at day 1 of inclusion. T cell and dendritic cell responses at day 1 are highly predictive for SARS-CoV-2-specific antibody responses after 3 weeks in mild but not hospitalized patients. Our systematic analysis reveals a combinatorial picture and trajectory of various arms of the highly coordinated early-stage immune responses in mild COVID-19 patients.
Disciplines :
Immunology & infectious disease
Author, co-author :
Capelle, Christophe M.
Ciré, Séverine
Domingues, Olivia
ERNENS, Isabelle ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
Hedin, Fanny
Fischer, Aurélie
Snoeck, Chantal J.
Ammerlaan, Wim
Konstantinou, Maria
GRZYB, Kamil ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling
SKUPIN, Alexander ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling
Carty, Cara L.
HILGER, Christiane ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
Gilson, Georges
Celebic, Aljosa
WILMES, Paul ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology
Del Sol, Antonio
Kaplan, Ian M.
BETSOU, Fay ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC)
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