Reference : Combinatorial analysis reveals highly coordinated early-stage immune reactions that p...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/10993/51826
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients
English
Capelle, Christophe M. [> >]
Ciré, Séverine [> >]
Domingues, Olivia [> >]
Ernens, Isabelle mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Hedin, Fanny [> >]
Fischer, Aurélie [> >]
Snoeck, Chantal J. [> >]
Ammerlaan, Wim [> >]
Konstantinou, Maria [> >]
Grzyb, Kamil mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling]
Carty, Cara L. [> >]
Hilger, Christiane mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Gilson, Georges [> >]
Celebic, Aljosa [> >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
Del Sol, Antonio [> >]
Kaplan, Ian M. [> >]
Betsou, Fay mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Abdelrahman, Tamir [> >]
Cosma, Antonio mailto [University of Luxembourg > >]
Vaillant, Michel [> >]
Fagherazzi, Guy mailto [University of Luxembourg > >]
Ollert, Markus mailto [University of Luxembourg > >]
He, Feng mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
2022
Cell Reports Medicine
2666-3791
3
4
100600
Yes
Cambridge
MA
[en] combinatorial analysis ; COVID-19 ; early-stage response ; immunology ; mild patients ; non-hospitalized ; predict antibody levels ; SARS-CoV-2 ; systems immunology ; transient cytokine response
[en] While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudinal cohort of 63 mild and 15 hospitalized patients versus 14 asymptomatic and 26 household controls. We observe a transient increase of IP10/CXCL10 and interferon-β levels, coordinated responses of dominant SARS-CoV-2-specific CD4 and fewer CD8 T cells, and various antigen-presenting and antibody-secreting cells in mild patients within 3 days of PCR diagnosis. The frequency of key innate immune cells and their functional marker expression are impaired in hospitalized patients at day 1 of inclusion. T cell and dendritic cell responses at day 1 are highly predictive for SARS-CoV-2-specific antibody responses after 3 weeks in mild but not hospitalized patients. Our systematic analysis reveals a combinatorial picture and trajectory of various arms of the highly coordinated early-stage immune responses in mild COVID-19 patients.
http://hdl.handle.net/10993/51826
10.1016/j.xcrm.2022.100600
https://www.sciencedirect.com/science/article/pii/S2666379122001173

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Limited access
Capelle_Combinatorial_analysis_immunity_COVID-19_patients_CellReports_2022.pdfPublisher postprint24.91 MBRequest a copy

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.