Article (Scientific journals)
Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease.
Gabbert, Carolin; König, Inke R.; Lüth, Theresa et al.
2022In Journal of Neurology
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Keywords :
Age at onset; Environment; Lifestyle; Modifiers; Parkinson’s disease
Abstract :
[en] Parkinson's disease (PD) is a progressive neurodegenerative disorder. Genetic modifiers, environmental factors and gene-environment interactions have been found to modify PD risk and disease progression. The objective of this study was to evaluate the association of smoking, caffeine and anti-inflammatory drugs with age at onset (AAO) in a large PD cohort. A total of 35,963 American patients with idiopathic PD (iPD) from the Fox Insight Study responded to health and lifestyle questionnaires. We compared the median AAO between different groups using the non-parametric Mann-Whitney U test. Non-parametric Spearman's correlation was used for correlation assessments and regression analysis was used to assess interaction between variables. We found that smoking (p < 0.0001), coffee drinking (p < 0.0001) and aspirin intake (p < 0.0001) show an exploratory association with AAO in PD, that was further supported by multivariate regression models. The association of aspirin with PD AAO was replicated in another cohort (EPIPARK) (n = 237 patients with PD).
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gabbert, Carolin
König, Inke R.
Lüth, Theresa
Kolms, Beke
Kasten, Meike
Vollstedt, Eva-Juliane
Balck, Alexander
Grünewald, Anne  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
Klein, Christine
Trinh, Joanne
External co-authors :
yes
Language :
English
Title :
Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease.
Publication date :
2022
Journal title :
Journal of Neurology
ISSN :
0340-5354
eISSN :
1432-1459
Publisher :
Dr. Dietrich Steinkopff Verlag, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The Michael J. Fox Foundation for Parkinson’s Research
Commentary :
© 2022. The Author(s).
Available on ORBilu :
since 31 March 2022

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