  | Lüth, T., Gabbert, C., Koch, S., König, I. R., Caliebe, A., Laabs, B.-H., Hentati, F., Sassi, S. B., Amouri, R., Spielmann, M., Klein, C., GRÜNEWALD, A., Farrer, M. J., & Trinh, J. (October 2023). Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism. Movement Disorders, 38 (10), 1837 - 1849. doi:10.1002/mds.29563  Peer Reviewed verified by ORBi |
 | MULICA, P., Venegas, C., LANDOULSI, Z., BADANJAK, K., DELCAMBRE, S., TZIORTZIOU, M., HEZZAZ, S., Ghelfi, J., SMAJIC, S., SCHWAMBORN, J. C., Krüger, R., ANTONY, P., MAY, P., GLAAB, E., GRÜNEWALD, A.* , & Pereira, S. L.*. (20 September 2023). Comparison of two protocols for the generation of iPSC-derived human astrocytes. Biological Procedures Online, 25 (1), 26. doi:10.1186/s12575-023-00218-x Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Trinh, J., Hicks, A. A., König, I. R., Delcambre, S., Lüth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilariño-Güell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostić, V., Lang, A. E., Brüggemann, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (July 2023). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease. Brain, 146 (7), 2753–2765. doi:10.1093/brain/awac464 Peer reviewed |
 | Gabbert, C., König, I. R., Lüth, T., Kasten, M., GRÜNEWALD, A., Klein, C., & Trinh, J. (12 June 2023). Lifestyle factors and clinical severity of Parkinson's disease. Scientific Reports, 13 (1), 9537. doi:10.1038/s41598-023-31531-w Peer Reviewed verified by ORBi |
 | Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., Antony, P., Boussaad, I., Bobbili, D. R., Sreelatha, A. A. K., Pavelka, L., Klein, C., Seibler, P., Glaab, E., Sharma, M., Krüger, R., May, P., & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877 |
 | Schepers, M., Paes, D., Tiane, A., Rombaut, B., Piccart, E., van Veggel, L., Gervois, P., Wolfs, E., Lambrichts, I., Brullo, C., Bruno, O., Fedele, E., Ricciarelli, R., Ffrench-Constant, C., Bechler, M. E., van Schaik, P., Baron, W., Lefevere, E., Wasner, K., ... Vanmierlo, T. (2023). Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain, Behavior and Immunity, 109, 1-22. doi:10.1016/j.bbi.2022.12.020 Peer Reviewed verified by ORBi |
 | Chemla, A., Arena, G., Saraiva, C., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Klein, C., Seibler, P., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem Cell Research, 69, 103085. doi:10.1016/j.scr.2023.103085 Peer Reviewed verified by ORBi |
 | Pereira, S. L., Grossmann, D., Delcambre, S., Hermann, A., & Grünewald, A. (2023). Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Current Opinion in Neurobiology, 80, 102720. doi:10.1016/j.conb.2023.102720 Peer Reviewed verified by ORBi |
 | Castelo Rueda, M. P., Zanon, A., Gilmozzi, V., Lavdas, A., Raftopoulou, A., Delcambre, S., Del Greco, F., Klein, C., Grünewald, A., Pramstaller, P., Hicks, A., & Pichler, I. (2023). Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers. NPJ Parkinson's Disease. doi:10.1038/s41531-023-00499-9 Peer Reviewed verified by ORBi |
 | Tiane, A., Schepers, M., Reijnders, R. A., van Veggel, L., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Grünewald, A., Prickaerts, J., Pishva, E., Hellings, N., van den Hove, D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions. Acta Neuropathologica. doi:10.1007/s00401-023-02596-8 Peer Reviewed verified by ORBi |
 | Lüth, T., Gabbert, C., König, I. R., Caliebe, A., Koch, S., Laabs, B.-H., Hentati, F., Sassi, S. B., Amouri, R., Spielmann, M., Klein, C., Grünewald, A., Farrer, M. J., & Trinh, J. (2023). Interaction of mitochondrial polygenic score and environmental factors in LRRK2 p.Gly2019Ser parkinsonism 2023.01.02.23284113. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55272. doi:10.1101/2023.01.02.23284113 |
 | Tiane, A., Schepers, M., Reijnders, R. A., Veggel, L. V., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Grünewald, A., Prickaerts, J., Pishva, E., Hellings, N., Hove, D. V. D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions 2023.01.12.523740. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55270. doi:10.1101/2023.01.12.523740 |
 | Chemla, A., Arena, G., Onal, G., Walter, J., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research, 103145. doi:10.1016/j.scr.2023.103145 Peer reviewed |
 | Grossmann, D., Malburg, N., Glaß, H., Weeren, V., Sondermann, V., Pfeiffer, J. F., Petters, J., Lukas, J., Seibler, P., Klein, C., Grünewald, A., & Hermann, A. (2023). Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29525 Peer reviewed |
 | Trinh, J., Hicks, A. A., Koenig, I. R., Delcambre, S., Lueth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilarino-Guell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostic, V., Lang, A. E., Brueggeman, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (2022). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51280. doi:10.1101/2022.05.17.22275087 |
 | Lüth, T., Schaake, S., Grünewald, A., May, P., Trinh, J., & Weissensteiner, H. (19 May 2022). Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA. Frontiers in Genetics, 13. doi:10.3389/fgene.2022.887644 Peer Reviewed verified by ORBi |
 | Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446 Peer Reviewed verified by ORBi |
 | Gabbert, C., König, I. R., Lüth, T., Kolms, B., Kasten, M., Vollstedt, E.-J., Balck, A., Grünewald, A., Klein, C., & Trinh, J. (2022). Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease. Journal of Neurology. doi:10.1007/s00415-022-11041-x Peer Reviewed verified by ORBi |
 | Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025 Peer reviewed |
 | Brunelli, F., Torosantucci, L., Gelmetti, V., Franzone, D., Grünewald, A., Krüger, R., Arena, G., & Valente, E. M. (2022). PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage. Cells, 11 (4). doi:10.3390/cells11040678 Peer Reviewed verified by ORBi |
  | Trinh, J., Schymanski, E., Smajic, S., Kasten, M., Sammler, E., & Grünewald, A. (2022). Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease. Medizinische Genetik, 34 (2), 103--116. doi:10.1515/medgen-2022-2127 Peer reviewed |
 | Lang, M., Grünewald, A., Pramstaller, P. P., Hicks, A. A., & Pichler, I. (2022). A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models. Cellular and molecular life sciences : CMLS, 79 (5), 283. doi:10.1007/s00018-022-04304-3 Peer reviewed |
 | Zagare, A., Barmpa, K., Smajic, S., Smits, L., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S. L., & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009 Peer Reviewed verified by ORBi |
 | Arena, G., Sharma, K., Agyeah, G., Krüger, R., Grünewald, A., & Fitzgerald, J. C. (2022). Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop. Current Neurology and Neuroscience Reports, 22 (8), 427 – 440. doi:10.1007/s11910-022-01207-5 Peer reviewed |
 | Lüth, T., Wasner, K., Klein, C., Schaake, S., Tse, R., Pereira, S. L., Laß, J., Sinkkonen, L., Grünewald, A., & Trinh, J. (2021). Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept. Frontiers in Aging Neuroscience. doi:10.3389/fnagi.2021.713084 Peer Reviewed verified by ORBi |
 | Usnich, T., Vollstedt, E.-J., Schell, N., Skrahina, V., Bogdanovic, X., Gaber, H., Förster, T. M., Heuer, A., Koleva-Alazeh, N., Csoti, I., Basak, A. N., Ertan, S., Genc, G., Bauer, P., Lohmann, K., Grünewald, A., Schymanski, E., Trinh, J., Schaake, S., ... Group, T. L. S. (2021). LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort. Frontiers in Neurology, 12, 710572. doi:10.3389/fneur.2021.710572 Peer Reviewed verified by ORBi |
 | Mulica, P., Grünewald, A., & Pereira, S. L. (2021). Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. Frontiers in Endocrinology, 12, 668517. doi:10.3389/fendo.2021.668517 Peer Reviewed verified by ORBi |
 | Kutschenko, A., Staege, S., Grütz, K., Glaß, H., Kalmbach, N., Gschwendtberger, T., Henkel, L. M., Heine, J., Grünewald, A., Hermann, A., Seibler, P., & Wegner, F. (2021). Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons. International Journal of Molecular Sciences, 22 (7). doi:10.3390/ijms22073565 Peer Reviewed verified by ORBi |
 | Badanjak, K., Fixemer, S., Smajic, S., Skupin, A., & Grünewald, A. (2021). The Contribution of Microglia to Neuroinflammation in Parkinson's Disease. International Journal of Molecular Sciences, 22 (9). doi:10.3390/ijms22094676 Peer Reviewed verified by ORBi |
 | Badanjak, K., Mulica, P., Smajic, S., Delcambre, S., Tranchevent, L.-C., Diederich, N., Rauen, T., Schwamborn, J. C., Glaab, E., Cowley, S. A., Antony, P., Pereira, S. L., Venegas, C., & Grünewald, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, 740758. doi:10.3389/fcell.2021.740758 Peer Reviewed verified by ORBi |
 | Gabbert, C., König, I., Lüth, T., Kolms, B., Kasten, M., Vollstedt, E.-J., Balck, A., Fox Insight Study, Grünewald, A., Klein, C., & Trinh, J. (2021). Coffee, smoking and aspirin are associated with age at onset and clinical severity in idiopathic Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/48879. |
 | Dulovic-Mahlow, M.* , König, I. R.* , Trinh, J.* , Haissatou Diaw, S., Urban, P. P., Knappe, E., Kuhnke, N., Ingwersen, L.-C., Hinrichs, F., Weber, J., Kupnicka, P., Balck, A., Delcambre, S., Vollbrandt, T., Grünewald, A., Klein, C., Seibler, P., & Lohmann, K. (2020). Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity. Annals of Neurology. doi:10.1002/ana.25942 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Borsche, M., Koenig, I., Delcambre, S., Petrucci, S., Balck, A., Brueggemann, N., Zimprich, A., Wasner, K., Cardoso Pereira, S. L., Avenali, M., Deuschle, C., Badanjak, K., Ghelfi, J., Gasser, T., Kasten, M., Rosenstiel, P., Lohmann, K., Brockmann, K., Valente, E. M., ... Klein, C. (2020). Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain: a Journal of Neurology. doi:10.1093/NTR/NTV039 Peer Reviewed verified by ORBi |
 | Neumann, M. A.-C.* , Grossmann, D.* , Schimpf-Linzenbold, S., Dayan, D., Stingl, K., Ben-Menachem, R., Pines, O., Massart, F., Delcambre, S., Ghelfi, J., Bohler, J., Strom, T., Kessel, A., Azem, A., Schöls, L., Grünewald, A., Wissinger, B., & Krüger, R. (2020). Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. doi:10.1038/s41598-020-73557-4 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Borsche, M., Pereira, S., Klein, C., & Grünewald, A. (2020). Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects. Journal of Parkinson's Disease. doi:10.3233/JPD-201981 Peer Reviewed verified by ORBi |
 | Lüth, T., König, I. R., Grünewald, A., Kasten, M., Klein, C., Hentati, F., Farrer, M., & Joanne, T. (October 2020). Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors. Movement Disorders, 35 (10), 1854-1858. doi:10.1002/mds.28238 Peer Reviewed verified by ORBi |
 | Wasner, K., Grünewald, A., & Klein, C. (2020). Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches. Neuroscience Research. doi:10.1016/j.neures.2020.09.001 Peer Reviewed verified by ORBi |
 | Delcambre, S., Ghelfi, J., Ouzren, N., Grandmougin, L., Delbrouck, C., Seibler, P., Wasner, K., Aasly, J., Klein, C., Trinh, J., Cardoso Pereira, S. L., & Grünewald, A. (2020). Mitochondrial Mechanisms of LRRK2 G2019S Penetrance. Frontiers in Neurology. doi:10.3389/fneur.2020.00881 Peer Reviewed verified by ORBi |
 | Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease. Human Molecular Genetics. doi:10.1093/hmg/ddaa066 Peer Reviewed verified by ORBi |
 | Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Dietrich, C., Jarazo, J., Henck, J., Balachan, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (2020). Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/49376. |
 | Berenguer, C., Grossmann, D., Massart, F., Antony, P., Burbulla, L., Glaab, E., Imhoff, S., Trinh, J., Seibler, P., Grünewald, A., & Krüger, R. (2019). Variants in Miro1 cause alterations of ER-mitochondria contact sites in fibroblasts from Parkinson's disease patients. Journal of Clinical Medicine. doi:10.3390/jcm8122226 Peer Reviewed verified by ORBi |
 | Ouzren, N., Delcambre, S., Ghelfi, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & Grünewald, A. (August 2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86 (2), 324-326. doi:10.1002/ana.25510 Peer Reviewed verified by ORBi |
 | Grossmann, D., Berenguer, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Hérouël, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Grünewald, A., & Krüger, R. (2019). Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease. Antioxidants & redox signaling. doi:10.1089/ars.2018.7718 Peer reviewed |
 | Grünewald, A., Kumar, K. R., & Sue, C. M. (June 2019). New insights into the complex role of mitochondria in Parkinson's disease. Progress in Neurobiology, 177, 73-93. doi:10.1016/j.pneurobio.2018.09.003 Peer Reviewed verified by ORBi |
 | Trinh, J.* , Zeldenrust, F. M. J.* , Huang, J.* , Kasten, M.* , Schaake, S., Petkovic, S., Madoev, H., Grünewald, A., Almuammar, S., König, I. R., Lill, C. M., Lohmann, K., Klein, C., & Marras, C. (December 2018). Genotype-phenotype relations for the Parkinson’s disease genes SNCA, LRRK2, VPS35: MDSGene Review. Movement Disorders, 33 (12), 1857-1870. doi:10.1002/mds.27527 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Lucumi Moreno, E., Nickels, S., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R. M. T., Antony, P., & Schwamborn, J. C. (2018). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science. doi:10.1002/advs.201800927 Peer Reviewed verified by ORBi |
 | Grünewald, A. (September 2018). Mutationen im VSP13D-Gen verursachen eine oftmals frühkindliche spastische Ataxie. DGNeurologie, 1 (1), 58-59. doi:10.1007/s42451-018-0005-7 Peer reviewed |
 | Vincent, A. E., Rosa, H. S., Pabis, K., Lawless, C., Chen, C., Grünewald, A., Rygiel, K. A., Rocha, M. C., Reeve, A. K., Falkous, G., Perissi, V., White, K., Davy, T., Petrof, B. J., Sayer, A. A., Cooper, C., Deehan, D., Taylor, R. W., Turnbull, D. M., & Picard, M. (August 2018). Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology, 84 (2), 289-301. doi:10.1002/ana.25288 Peer Reviewed verified by ORBi |
 | Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, A., Schwienbacher, C., Serafin, A., Rudolf, F., Grünewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A., Bodmer, R., Pramstaller, P., Klein, C., Hicks, A., Pichler, I., & Seibler, P. (2017). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Human Molecular Genetics. doi:10.1093/hmg/ddx132 Peer Reviewed verified by ORBi |
 | Wagner, J., Vulinovic, F., Grünewald, A., Unger, M., Möller, C., Klein, C., Michel, P., Ries, V., Oertel, W., & Alvarez-Fischer, D. (2017). Acylated and unacylated ghrelin confers neuroprotection to mesencephalic neurons. Neuroscience. doi:10.1016/j.neuroscience.2017.09.045 Peer Reviewed verified by ORBi |
 | Grütz, K., Weisbach, A., Lohmann, K., Carlisle, F., Blake, D. J., Westenberger, A., Klein, C., & Grünewald, A. (2017). Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Scientific Reports. doi:10.1038/srep41156 Peer Reviewed verified by ORBi |
 | Grünewald, A., Rygiel, K. A., Hepplewhite, P. D., Morris, C. M., Picard, M., & Turnbull, D. M. (March 2016). Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Annals of Neurology, 79 (3), 366-378. doi:10.1002/ana.24571 Peer Reviewed verified by ORBi |
 | Grünewald, A., & Klein, C. (2016). Urinary LRRK2 phosphorylation: Penetrating the thicket of Parkinson disease? Neurology. doi:10.1212/WNL.0000000000002438 Peer Reviewed verified by ORBi |
Deuse, T., Wang, D., Stubbendorff, M., Itagaki, R., Grabosch, A., Greaves, L. C., Alawi, M., Grünewald, A., Hu, X., Hua, X., Velden, J., Reichenspurner, H., Robbins, R. C., Jaenisch, R., Weissman, I. L., & Schrepfer, S. (2015). SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell, 16 (1), 33-8. doi:10.1016/j.stem.2014.11.003 Peer Reviewed verified by ORBi |
Rocha, M. C.* , Grady, J. P.* , Grünewald, A., Vincent, A., Dobson, P. F., Taylor, R. W., Turnbull, D. M., & Rygiel, K. A. (2015). A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis. Scientific Reports, 5, 15037. doi:10.1038/srep15037 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
Erogullari, A., Hollstein, R., Seibler, P., Braunholz, D., Koschmidder, E., Depping, R., Eckhold, J., Lohnau, T., Gillessen-Kaesbach, G., Grünewald, A., Rakovic, A., Lohmann, K., & Kaiser, F. J. (2014). THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression. Biochimica et biophysica acta, 1839 (11), 1196-204. doi:10.1016/j.bbagrm.2014.07.019 Peer reviewed |
Grünewald, A.* , Arns, B.* , Meier, B., Brockmann, K., Tadic, V., & Klein, C. (2014). Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease? Antioxidants & redox signaling, 20 (13), 1955-60. doi:10.1089/ars.2013.5737 Peer reviewed* These authors have contributed equally to this work. |
Lohmann, K., Schmidt, A., Schillert, A., Winkler, S., Albanese, A., Baas, F., Bentivoglio, A. R., Borngraber, F., Bruggemann, N., Defazio, G., Del Sorbo, F., Deuschl, G., Edwards, M. J., Gasser, T., Gomez-Garre, P., Graf, J., Groen, J. L., Grünewald, A., Hagenah, J., ... Klein, C. (2014). Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus? Movement Disorders, 29 (7), 921-7. doi:10.1002/mds.25791 Peer Reviewed verified by ORBi |
Grünewald, A., Lax, N. Z., Rocha, M. C., Reeve, A. K., Hepplewhite, P. D., Rygiel, K. A., Taylor, R. W., & Turnbull, D. M. (2014). Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. Journal of Neuroscience Methods, 232, 143-9. doi:10.1016/j.jneumeth.2014.05.026 Peer Reviewed verified by ORBi |
Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grünewald, A., Seibler, P., Klein, C., Gevaert, K., Verstreken, P., & De Strooper, B. (2014). PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science, 344 (6180), 203-7. doi:10.1126/science.1249161 Peer Reviewed verified by ORBi |
Grünewald, A.* , Kasten, M.* , Ziegler, A., & Klein, C. (2013). Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurology, 70 (9), 1186-91. doi:10.1001/jamaneurol.2013.488 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D., & Klein, C. (2013). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of biological chemistry, 288 (4), 2223-37. doi:10.1074/jbc.M112.391680 Peer reviewed |
Kumar, K. R., Blair, N. F., Vandebona, H., Liang, C., Ng, K., Sharpe, D. M., Grünewald, A., Golnitz, U., Saviouk, V., Rolfs, A., Klein, C., & Sue, C. M. (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of Neurology, 260 (10), 2516-22. doi:10.1007/s00415-013-7008-x Peer Reviewed verified by ORBi |
Alvarez-Fischer, D., Noelker, C., Grünewald, A., Vulinovic, F., Guerreiro, S., Fuchs, J., Lu, L., Lombes, A., Hirsch, E. C., Oertel, W. H., Michel, P. P., & Hartmann, A. (2013). Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism. Journal of Neurochemistry, 127 (6), 782-92. doi:10.1111/jnc.12343 Peer Reviewed verified by ORBi |
Alvarez-Fischer, D., Noelker, C., Vulinovic, F., Grünewald, A., Chevarin, C., Klein, C., Oertel, W. H., Hirsch, E. C., Michel, P. P., & Hartmann, A. (2013). Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PLoS ONE, 8 (4), 61700. doi:10.1371/journal.pone.0061700 Peer Reviewed verified by ORBi |
Kumar, K. R., Ramirez, A., Gobel, A., Kresojevic, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V., & Grünewald, A. (2013). Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European Journal of Neurology, 20 (2), 402-5. doi:10.1111/j.1468-1331.2012.03817.x Peer Reviewed verified by ORBi |
Kasten, M., Grünewald, A., & Klein, C. (2013). Next-generation phenotyping and genomic incidental findings--reply. JAMA Neurology, 70 (12), 1590-1. doi:10.1001/jamaneurol.2013.4812 Peer Reviewed verified by ORBi |
Freimann, K., Zschiedrich, K., Bruggemann, N., Grünewald, A., Pawlack, H., Hagenah, J., Lohmann, K., Klein, C., & Westenberger, A. (2013). Mortalin mutations are not a frequent cause of early-onset Parkinson disease. Neurobiology of Aging, 34 (11), 2694.e19-20. doi:10.1016/j.neurobiolaging.2013.05.021 Peer Reviewed verified by ORBi |
Weissbach, A., Kasten, M., Grünewald, A., Bruggemann, N., Trillenberg, P., Klein, C., & Hagenah, J. (2013). Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia. Parkinsonism and Related Disorders, 19 (4), 422-5. doi:10.1016/j.parkreldis.2012.12.004 Peer Reviewed verified by ORBi |
Wortmann, S. B., Vaz, F. M., Gardeitchik, T., Vissers, L. E. L. M., Renkema, G. H., Schuurs-Hoeijmakers, J. H. M., Kulik, W., Lammens, M., Christin, C., Kluijtmans, L. A. J., Rodenburg, R. J., Nijtmans, L. G. J., Grünewald, A., Klein, C., Gerhold, J. M., Kozicz, T., van Hasselt, P. M., Harakalova, M., Kloosterman, W., ... de Brouwer, A. P. M. (2012). Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nature Genetics, 44 (7), 797-802. doi:10.1038/ng.2325 Peer Reviewed verified by ORBi |
Schmidt, A., Kumar, K. R., Redyk, K., Grünewald, A., Leben, M., Munchau, A., Sue, C. M., Hagenah, J., Hartmann, H., Lohmann, K., Christen, H.-J., & Klein, C. (2012). Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations. Archives of Neurology, 69 (5), 668-70. doi:10.1001/archneurol.2012.187 Peer Reviewed verified by ORBi |
Grünewald, A.* , Arns, B.* , Seibler, P., Rakovic, A., Munchau, A., Ramirez, A., Sue, C. M., & Klein, C. (2012). ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiology of Aging, 33 (8), 1843.e1-7. doi:10.1016/j.neurobiolaging.2011.12.035 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
Abramov, A. Y., Gegg, M., Grünewald, A., Wood, N. W., Klein, C., & Schapira, A. H. V. (2011). Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS ONE, 6 (10), 25622. doi:10.1371/journal.pone.0025622 Peer Reviewed verified by ORBi |
Kumar, K. R., Djarmati-Westenberger, A., & Grünewald, A. (2011). Genetics of Parkinson's disease. Seminars in Neurology, 31 (5), 433-40. doi:10.1055/s-0031-1299782 Peer Reviewed verified by ORBi |
Rakovic, A.* , Grünewald, A.* , Kottwitz, J., Bruggemann, N., Pramstaller, P. P., Lohmann, K., & Klein, C. (2011). Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS ONE, 6 (3), 16746. doi:10.1371/journal.pone.0016746 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
Rakovic, A.* , Grünewald, A.* , Voges, L., Hofmann, S., Orolicki, S., Lohmann, K., & Klein, C. (2011). PINK1-interacting proteins: Proteomic analysis of overexpressed PINK1. Parkinsons Dis, 2011, 153979. doi:10.4061/2011/153979 Peer reviewed* These authors have contributed equally to this work. |
Arif, B., Grünewald, A., Fatima, A., Ramirez, A., Ali, A., Bruggemann, N., Wurfel, J., Rolfs, A., Lohmann, K., Malik, A., Klein, C., & Naz, S. (2011). An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech. Movement Disorders, 26 (12), 2279-83. doi:10.1002/mds.23860 Peer Reviewed verified by ORBi |
Grünewald, A., Voges, L., Rakovic, A., Kasten, M., Vandebona, H., Hemmelmann, C., Lohmann, K., Orolicki, S., Ramirez, A., Schapira, A. H. V., Pramstaller, P. P., Sue, C. M., & Klein, C. (2010). Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS ONE, 5 (9), 12962. doi:10.1371/journal.pone.0012962 Peer Reviewed verified by ORBi |
Rakovic, A., Grünewald, A., Seibler, P., Ramirez, A., Kock, N., Orolicki, S., Lohmann, K., & Klein, C. (2010). Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Human Molecular Genetics, 19 (16), 3124-37. doi:10.1093/hmg/ddq215 Peer Reviewed verified by ORBi |
Grünewald, A., Gegg, M. E., Taanman, J.-W., King, R. H., Kock, N., Klein, C., & Schapira, A. H. V. (2009). Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Experimental Neurology, 219 (1), 266-73. doi:10.1016/j.expneurol.2009.05.027 Peer Reviewed verified by ORBi |
Grünewald, A., Djarmati, A., Lohmann-Hedrich, K., Farrell, K., Zeller, J. A., Allert, N., Papengut, F., Petersen, B., Fung, V., Sue, C. M., O'Sullivan, D., Mahant, N., Kupsch, A., Chuang, R. S., Wiegers, K., Pawlack, H., Hagenah, J., Ozelius, L. J., Stephani, U., ... Klein, C. (2008). Myoclonus-dystonia: significance of large SGCE deletions. Human Mutation, 29 (2), 331-2. doi:10.1002/humu.9521 Peer Reviewed verified by ORBi |
Brueggemann, N., Odin, P., Grünewald, A., Tadic, V., Hagenah, J., Seidel, G., Lohmann, K., Klein, C., & Djarmati, A. (2008). Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease. Neurology, 71 (16), 1294; author reply 1294. doi:10.1212/01.wnl.0000338439.00992.c7 Peer Reviewed verified by ORBi |
Paus, S., Grünewald, A., Klein, C., Knapp, M., Zimprich, A., Janetzky, B., Moller, J. C., Klockgether, T., & Wullner, U. (2008). The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease. Movement Disorders, 23 (4), 599-602. doi:10.1002/mds.21901 Peer Reviewed verified by ORBi |
Grünewald, A., Breedveld, G. J., Lohmann-Hedrich, K., Rohe, C. F., Konig, I. R., Hagenah, J., Vanacore, N., Meco, G., Antonini, A., Goldwurm, S., Lesage, S., Durr, A., Binkofski, F., Siebner, H., Munchau, A., Brice, A., Oostra, B. A., Klein, C., & Bonifati, V. (2007). Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis. Neurogenetics, 8 (2), 103-9. doi:10.1007/s10048-006-0072-y Peer reviewed |
Orth, M., Djarmati, A., Baumer, T., Winkler, S., Grünewald, A., Lohmann-Hedrich, K., Kabakci, K., Hagenah, J., Klein, C., & Munchau, A. (2007). Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene. Movement Disorders, 22 (14), 2090-6. doi:10.1002/mds.21674 Peer reviewed |
Djarmati, A.* , Guzvic, M.* , Grünewald, A., Lang, A. E., Pramstaller, P. P., Simon, D. K., Kaindl, A. M., Vieregge, P., Nygren, A. O. H., Beetz, C., Hedrich, K., & Klein, C. (2007). Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Movement Disorders, 22 (12), 1708-14. doi:10.1002/mds.21370 Peer reviewed* These authors have contributed equally to this work. |
Hedrich, K., Hagenah, J., Djarmati, A., Hiller, A., Lohnau, T., Lasek, K., Grünewald, A., Hilker, R., Steinlechner, S., Boston, H., Kock, N., Schneider-Gold, C., Kress, W., Siebner, H., Binkofski, F., Lencer, R., Munchau, A., & Klein, C. (2006). Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Archives of neurology, 63 (6), 833-8. doi:10.1001/archneur.63.6.833 Peer reviewed |
Klein, C., Grünewald, A., & Hedrich, K. (2006). Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology, 66 (7), 1129-30; author reply 1129-30. doi:10.1212/01.wnl.0000220157.81513.85 Peer Reviewed verified by ORBi |
