Profil

GRÜNEWALD Anne

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology

ORCID
0000-0002-4179-2994
Main Referenced Co-authors
KLEIN, Christine  (28)
Klein, Christine (24)
Trinh, Joanne (17)
Lohmann, Katja (16)
DELCAMBRE, Sylvie  (14)
Main Referenced Keywords
Humans (36); Female (18); Male (18); Middle Aged (15); Adult (14);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (5)
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) (3)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Molecular and Functional Neurobiology (Grünewald Group) (2)
LIH - Luxembourg Institute of Health (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (61)
Genetics & genetic processes (17)
Neurology (6)
Laboratory medicine & medical technology (1)
Human health sciences: Multidisciplinary, general & others (1)

Publications (total 88)

The most downloaded
709 downloads
Grünewald, A., Kumar, K. R., & Sue, C. M. (June 2019). New insights into the complex role of mitochondria in Parkinson's disease. Progress in Neurobiology, 177, 73-93. doi:10.1016/j.pneurobio.2018.09.003 https://hdl.handle.net/10993/37535

The most cited

275 citations (Scopus®)

Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grünewald, A., Seibler, P., Klein, C., Gevaert, K., Verstreken, P., & De Strooper, B. (2014). PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science, 344 (6180), 203-7. doi:10.1126/science.1249161 https://hdl.handle.net/10993/24448

Lüth, T., Gabbert, C., Koch, S., König, I. R., Caliebe, A., Laabs, B.-H., Hentati, F., Sassi, S. B., Amouri, R., Spielmann, M., Klein, C., GRÜNEWALD, A., Farrer, M. J., & Trinh, J. (October 2023). Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism. Movement Disorders, 38 (10), 1837 - 1849. doi:10.1002/mds.29563
Peer Reviewed verified by ORBi

MULICA, P., Venegas, C., LANDOULSI, Z., BADANJAK, K., DELCAMBRE, S., TZIORTZIOU, M., HEZZAZ, S., Ghelfi, J., SMAJIC, S., SCHWAMBORN, J. C., Krüger, R., ANTONY, P., MAY, P., GLAAB, E., GRÜNEWALD, A.* , & Pereira, S. L.*. (20 September 2023). Comparison of two protocols for the generation of iPSC-derived human astrocytes. Biological Procedures Online, 25 (1), 26. doi:10.1186/s12575-023-00218-x
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* These authors have contributed equally to this work.

Trinh, J., Hicks, A. A., König, I. R., Delcambre, S., Lüth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilariño-Güell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostić, V., Lang, A. E., Brüggemann, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (July 2023). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease. Brain, 146 (7), 2753–2765. doi:10.1093/brain/awac464
Peer reviewed

Gabbert, C., König, I. R., Lüth, T., Kasten, M., GRÜNEWALD, A., Klein, C., & Trinh, J. (12 June 2023). Lifestyle factors and clinical severity of Parkinson's disease. Scientific Reports, 13 (1), 9537. doi:10.1038/s41598-023-31531-w
Peer Reviewed verified by ORBi

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., Antony, P., Boussaad, I., Bobbili, D. R., Sreelatha, A. A. K., Pavelka, L., Klein, C., Seibler, P., Glaab, E., Sharma, M., Krüger, R., May, P., & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877

Chemla, A., Arena, G., Saraiva, C., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Klein, C., Seibler, P., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem Cell Research, 69, 103085. doi:10.1016/j.scr.2023.103085
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Schepers, M., Paes, D., Tiane, A., Rombaut, B., Piccart, E., van Veggel, L., Gervois, P., Wolfs, E., Lambrichts, I., Brullo, C., Bruno, O., Fedele, E., Ricciarelli, R., Ffrench-Constant, C., Bechler, M. E., van Schaik, P., Baron, W., Lefevere, E., Wasner, K., ... Vanmierlo, T. (2023). Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain, Behavior and Immunity, 109, 1-22. doi:10.1016/j.bbi.2022.12.020
Peer Reviewed verified by ORBi

Pereira, S. L., Grossmann, D., Delcambre, S., Hermann, A., & Grünewald, A. (2023). Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Current Opinion in Neurobiology, 80, 102720. doi:10.1016/j.conb.2023.102720
Peer Reviewed verified by ORBi

Castelo Rueda, M. P., Zanon, A., Gilmozzi, V., Lavdas, A., Raftopoulou, A., Delcambre, S., Del Greco, F., Klein, C., Grünewald, A., Pramstaller, P., Hicks, A., & Pichler, I. (2023). Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers. NPJ Parkinson's Disease. doi:10.1038/s41531-023-00499-9
Peer Reviewed verified by ORBi

Tiane, A., Schepers, M., Reijnders, R. A., Veggel, L. V., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Grünewald, A., Prickaerts, J., Pishva, E., Hellings, N., Hove, D. V. D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions 2023.01.12.523740. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55270. doi:10.1101/2023.01.12.523740

Tiane, A., Schepers, M., Reijnders, R. A., van Veggel, L., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Grünewald, A., Prickaerts, J., Pishva, E., Hellings, N., van den Hove, D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions. Acta Neuropathologica. doi:10.1007/s00401-023-02596-8
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Lüth, T., Gabbert, C., König, I. R., Caliebe, A., Koch, S., Laabs, B.-H., Hentati, F., Sassi, S. B., Amouri, R., Spielmann, M., Klein, C., Grünewald, A., Farrer, M. J., & Trinh, J. (2023). Interaction of mitochondrial polygenic score and environmental factors in LRRK2 p.Gly2019Ser parkinsonism 2023.01.02.23284113. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55272. doi:10.1101/2023.01.02.23284113

Grossmann, D., Malburg, N., Glaß, H., Weeren, V., Sondermann, V., Pfeiffer, J. F., Petters, J., Lukas, J., Seibler, P., Klein, C., Grünewald, A., & Hermann, A. (2023). Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29525
Peer reviewed

Chemla, A., Arena, G., Onal, G., Walter, J., Berenguer-Escuder, C., Grossmann, D., Grünewald, A., Schwamborn, J. C., & Krüger, R. (2023). Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1. Stem Cell Research, 103145. doi:10.1016/j.scr.2023.103145
Peer reviewed

Trinh, J., Hicks, A. A., Koenig, I. R., Delcambre, S., Lueth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilarino-Guell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostic, V., Lang, A. E., Brueggeman, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (2022). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51280. doi:10.1101/2022.05.17.22275087

Lüth, T., Schaake, S., Grünewald, A., May, P., Trinh, J., & Weissensteiner, H. (19 May 2022). Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA. Frontiers in Genetics, 13. doi:10.3389/fgene.2022.887644
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Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446
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Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025
Peer reviewed

Trinh, J., Schymanski, E., Smajic, S., Kasten, M., Sammler, E., & Grünewald, A. (2022). Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease. Medizinische Genetik, 34 (2), 103--116. doi:10.1515/medgen-2022-2127
Peer reviewed

Zagare, A., Barmpa, K., Smajic, S., Smits, L., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S. L., & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. American Journal of Human Genetics. doi:10.1016/j.ajhg.2021.12.009
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Brunelli, F., Torosantucci, L., Gelmetti, V., Franzone, D., Grünewald, A., Krüger, R., Arena, G., & Valente, E. M. (2022). PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage. Cells, 11 (4). doi:10.3390/cells11040678
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Gabbert, C., König, I. R., Lüth, T., Kolms, B., Kasten, M., Vollstedt, E.-J., Balck, A., Grünewald, A., Klein, C., & Trinh, J. (2022). Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease. Journal of Neurology. doi:10.1007/s00415-022-11041-x
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Lang, M., Grünewald, A., Pramstaller, P. P., Hicks, A. A., & Pichler, I. (2022). A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models. Cellular and molecular life sciences : CMLS, 79 (5), 283. doi:10.1007/s00018-022-04304-3
Peer reviewed

Arena, G., Sharma, K., Agyeah, G., Krüger, R., Grünewald, A., & Fitzgerald, J. C. (2022). Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop. Current Neurology and Neuroscience Reports, 22 (8), 427 – 440. doi:10.1007/s11910-022-01207-5
Peer reviewed

Lüth, T., Wasner, K., Klein, C., Schaake, S., Tse, R., Pereira, S. L., Laß, J., Sinkkonen, L., Grünewald, A., & Trinh, J. (2021). Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept. Frontiers in Aging Neuroscience. doi:10.3389/fnagi.2021.713084
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Badanjak, K., Mulica, P., Smajic, S., Delcambre, S., Tranchevent, L.-C., Diederich, N., Rauen, T., Schwamborn, J. C., Glaab, E., Cowley, S. A., Antony, P., Pereira, S. L., Venegas, C., & Grünewald, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, 740758. doi:10.3389/fcell.2021.740758
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Gabbert, C., König, I., Lüth, T., Kolms, B., Kasten, M., Vollstedt, E.-J., Balck, A., Fox Insight Study, Grünewald, A., Klein, C., & Trinh, J. (2021). Coffee, smoking and aspirin are associated with age at onset and clinical severity in idiopathic Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/48879.

Badanjak, K., Fixemer, S., Smajic, S., Skupin, A., & Grünewald, A. (2021). The Contribution of Microglia to Neuroinflammation in Parkinson's Disease. International Journal of Molecular Sciences, 22 (9). doi:10.3390/ijms22094676
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Usnich, T., Vollstedt, E.-J., Schell, N., Skrahina, V., Bogdanovic, X., Gaber, H., Förster, T. M., Heuer, A., Koleva-Alazeh, N., Csoti, I., Basak, A. N., Ertan, S., Genc, G., Bauer, P., Lohmann, K., Grünewald, A., Schymanski, E., Trinh, J., Schaake, S., ... Group, T. L. S. (2021). LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort. Frontiers in Neurology, 12, 710572. doi:10.3389/fneur.2021.710572
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Kutschenko, A., Staege, S., Grütz, K., Glaß, H., Kalmbach, N., Gschwendtberger, T., Henkel, L. M., Heine, J., Grünewald, A., Hermann, A., Seibler, P., & Wegner, F. (2021). Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons. International Journal of Molecular Sciences, 22 (7). doi:10.3390/ijms22073565
Peer Reviewed verified by ORBi

Mulica, P., Grünewald, A., & Pereira, S. L. (2021). Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. Frontiers in Endocrinology, 12, 668517. doi:10.3389/fendo.2021.668517
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Dulovic-Mahlow, M.* , König, I. R.* , Trinh, J.* , Haissatou Diaw, S., Urban, P. P., Knappe, E., Kuhnke, N., Ingwersen, L.-C., Hinrichs, F., Weber, J., Kupnicka, P., Balck, A., Delcambre, S., Vollbrandt, T., Grünewald, A., Klein, C., Seibler, P., & Lohmann, K. (2020). Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity. Annals of Neurology. doi:10.1002/ana.25942
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Borsche, M., Koenig, I., Delcambre, S., Petrucci, S., Balck, A., Brueggemann, N., Zimprich, A., Wasner, K., Cardoso Pereira, S. L., Avenali, M., Deuschle, C., Badanjak, K., Ghelfi, J., Gasser, T., Kasten, M., Rosenstiel, P., Lohmann, K., Brockmann, K., Valente, E. M., ... Klein, C. (2020). Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain: a Journal of Neurology. doi:10.1093/NTR/NTV039
Peer Reviewed verified by ORBi

Neumann, M. A.-C.* , Grossmann, D.* , Schimpf-Linzenbold, S., Dayan, D., Stingl, K., Ben-Menachem, R., Pines, O., Massart, F., Delcambre, S., Ghelfi, J., Bohler, J., Strom, T., Kessel, A., Azem, A., Schöls, L., Grünewald, A., Wissinger, B., & Krüger, R. (2020). Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. doi:10.1038/s41598-020-73557-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Borsche, M., Pereira, S., Klein, C., & Grünewald, A. (2020). Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects. Journal of Parkinson's Disease. doi:10.3233/JPD-201981
Peer Reviewed verified by ORBi

Lüth, T., König, I. R., Grünewald, A., Kasten, M., Klein, C., Hentati, F., Farrer, M., & Joanne, T. (October 2020). Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors. Movement Disorders, 35 (10), 1854-1858. doi:10.1002/mds.28238
Peer Reviewed verified by ORBi

Wasner, K., Grünewald, A., & Klein, C. (2020). Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches. Neuroscience Research. doi:10.1016/j.neures.2020.09.001
Peer Reviewed verified by ORBi

Delcambre, S., Ghelfi, J., Ouzren, N., Grandmougin, L., Delbrouck, C., Seibler, P., Wasner, K., Aasly, J., Klein, C., Trinh, J., Cardoso Pereira, S. L., & Grünewald, A. (2020). Mitochondrial Mechanisms of LRRK2 G2019S Penetrance. Frontiers in Neurology. doi:10.3389/fneur.2020.00881
Peer Reviewed verified by ORBi

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Dietrich, C., Jarazo, J., Henck, J., Balachan, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (2020). Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/49376.

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease. Human Molecular Genetics. doi:10.1093/hmg/ddaa066
Peer Reviewed verified by ORBi

Berenguer, C., Grossmann, D., Massart, F., Antony, P., Burbulla, L., Glaab, E., Imhoff, S., Trinh, J., Seibler, P., Grünewald, A., & Krüger, R. (2019). Variants in Miro1 cause alterations of ER-mitochondria contact sites in fibroblasts from Parkinson's disease patients. Journal of Clinical Medicine. doi:10.3390/jcm8122226
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Ouzren, N., Delcambre, S., Ghelfi, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & Grünewald, A. (August 2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86 (2), 324-326. doi:10.1002/ana.25510
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Grossmann, D., Berenguer, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Hérouël, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Grünewald, A., & Krüger, R. (2019). Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease. Antioxidants & redox signaling. doi:10.1089/ars.2018.7718
Peer reviewed

Grünewald, A., Kumar, K. R., & Sue, C. M. (June 2019). New insights into the complex role of mitochondria in Parkinson's disease. Progress in Neurobiology, 177, 73-93. doi:10.1016/j.pneurobio.2018.09.003
Peer Reviewed verified by ORBi

Trinh, J.* , Zeldenrust, F. M. J.* , Huang, J.* , Kasten, M.* , Schaake, S., Petkovic, S., Madoev, H., Grünewald, A., Almuammar, S., König, I. R., Lill, C. M., Lohmann, K., Klein, C., & Marras, C. (December 2018). Genotype-phenotype relations for the Parkinson’s disease genes SNCA, LRRK2, VPS35: MDSGene Review. Movement Disorders, 33 (12), 1857-1870. doi:10.1002/mds.27527
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Lucumi Moreno, E., Nickels, S., Wasner, K., Ouzren, N., Walter, J., Grünewald, A., Glaab, E., Salamanca, L., Fleming, R. M. T., Antony, P., & Schwamborn, J. C. (2018). 3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Advanced Science. doi:10.1002/advs.201800927
Peer Reviewed verified by ORBi

Grünewald, A. (September 2018). Mutationen im VSP13D-Gen verursachen eine oftmals frühkindliche spastische Ataxie. DGNeurologie, 1 (1), 58-59. doi:10.1007/s42451-018-0005-7
Peer reviewed

Vincent, A. E., Rosa, H. S., Pabis, K., Lawless, C., Chen, C., Grünewald, A., Rygiel, K. A., Rocha, M. C., Reeve, A. K., Falkous, G., Perissi, V., White, K., Davy, T., Petrof, B. J., Sayer, A. A., Cooper, C., Deehan, D., Taylor, R. W., Turnbull, D. M., & Picard, M. (August 2018). Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology, 84 (2), 289-301. doi:10.1002/ana.25288
Peer Reviewed verified by ORBi

Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, A., Schwienbacher, C., Serafin, A., Rudolf, F., Grünewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A., Bodmer, R., Pramstaller, P., Klein, C., Hicks, A., Pichler, I., & Seibler, P. (2017). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Human Molecular Genetics. doi:10.1093/hmg/ddx132
Peer Reviewed verified by ORBi

Wagner, J., Vulinovic, F., Grünewald, A., Unger, M., Möller, C., Klein, C., Michel, P., Ries, V., Oertel, W., & Alvarez-Fischer, D. (2017). Acylated and unacylated ghrelin confers neuroprotection to mesencephalic neurons. Neuroscience. doi:10.1016/j.neuroscience.2017.09.045
Peer Reviewed verified by ORBi

Grütz, K., Weisbach, A., Lohmann, K., Carlisle, F., Blake, D. J., Westenberger, A., Klein, C., & Grünewald, A. (2017). Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Scientific Reports. doi:10.1038/srep41156
Peer Reviewed verified by ORBi

Grünewald, A., Rygiel, K. A., Hepplewhite, P. D., Morris, C. M., Picard, M., & Turnbull, D. M. (March 2016). Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Annals of Neurology, 79 (3), 366-378. doi:10.1002/ana.24571
Peer Reviewed verified by ORBi

Grünewald, A., & Klein, C. (2016). Urinary LRRK2 phosphorylation: Penetrating the thicket of Parkinson disease? Neurology. doi:10.1212/WNL.0000000000002438
Peer Reviewed verified by ORBi

Rocha, M. C.* , Grady, J. P.* , Grünewald, A., Vincent, A., Dobson, P. F., Taylor, R. W., Turnbull, D. M., & Rygiel, K. A. (2015). A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis. Scientific Reports, 5, 15037. doi:10.1038/srep15037
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Deuse, T., Wang, D., Stubbendorff, M., Itagaki, R., Grabosch, A., Greaves, L. C., Alawi, M., Grünewald, A., Hu, X., Hua, X., Velden, J., Reichenspurner, H., Robbins, R. C., Jaenisch, R., Weissman, I. L., & Schrepfer, S. (2015). SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell, 16 (1), 33-8. doi:10.1016/j.stem.2014.11.003
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Erogullari, A., Hollstein, R., Seibler, P., Braunholz, D., Koschmidder, E., Depping, R., Eckhold, J., Lohnau, T., Gillessen-Kaesbach, G., Grünewald, A., Rakovic, A., Lohmann, K., & Kaiser, F. J. (2014). THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression. Biochimica et biophysica acta, 1839 (11), 1196-204. doi:10.1016/j.bbagrm.2014.07.019
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Grünewald, A.* , Arns, B.* , Meier, B., Brockmann, K., Tadic, V., & Klein, C. (2014). Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease? Antioxidants & redox signaling, 20 (13), 1955-60. doi:10.1089/ars.2013.5737
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* These authors have contributed equally to this work.

Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grünewald, A., Seibler, P., Klein, C., Gevaert, K., Verstreken, P., & De Strooper, B. (2014). PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science, 344 (6180), 203-7. doi:10.1126/science.1249161
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Lohmann, K., Schmidt, A., Schillert, A., Winkler, S., Albanese, A., Baas, F., Bentivoglio, A. R., Borngraber, F., Bruggemann, N., Defazio, G., Del Sorbo, F., Deuschl, G., Edwards, M. J., Gasser, T., Gomez-Garre, P., Graf, J., Groen, J. L., Grünewald, A., Hagenah, J., ... Klein, C. (2014). Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus? Movement Disorders, 29 (7), 921-7. doi:10.1002/mds.25791
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Grünewald, A., Lax, N. Z., Rocha, M. C., Reeve, A. K., Hepplewhite, P. D., Rygiel, K. A., Taylor, R. W., & Turnbull, D. M. (2014). Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. Journal of Neuroscience Methods, 232, 143-9. doi:10.1016/j.jneumeth.2014.05.026
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Kasten, M., Grünewald, A., & Klein, C. (2013). Next-generation phenotyping and genomic incidental findings--reply. JAMA Neurology, 70 (12), 1590-1. doi:10.1001/jamaneurol.2013.4812
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Grünewald, A.* , Kasten, M.* , Ziegler, A., & Klein, C. (2013). Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurology, 70 (9), 1186-91. doi:10.1001/jamaneurol.2013.488
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* These authors have contributed equally to this work.

Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D., & Klein, C. (2013). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of biological chemistry, 288 (4), 2223-37. doi:10.1074/jbc.M112.391680
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Kumar, K. R., Blair, N. F., Vandebona, H., Liang, C., Ng, K., Sharpe, D. M., Grünewald, A., Golnitz, U., Saviouk, V., Rolfs, A., Klein, C., & Sue, C. M. (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of Neurology, 260 (10), 2516-22. doi:10.1007/s00415-013-7008-x
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Alvarez-Fischer, D., Noelker, C., Grünewald, A., Vulinovic, F., Guerreiro, S., Fuchs, J., Lu, L., Lombes, A., Hirsch, E. C., Oertel, W. H., Michel, P. P., & Hartmann, A. (2013). Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism. Journal of Neurochemistry, 127 (6), 782-92. doi:10.1111/jnc.12343
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Alvarez-Fischer, D., Noelker, C., Vulinovic, F., Grünewald, A., Chevarin, C., Klein, C., Oertel, W. H., Hirsch, E. C., Michel, P. P., & Hartmann, A. (2013). Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PLoS ONE, 8 (4), 61700. doi:10.1371/journal.pone.0061700
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Kumar, K. R., Ramirez, A., Gobel, A., Kresojevic, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V., & Grünewald, A. (2013). Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European Journal of Neurology, 20 (2), 402-5. doi:10.1111/j.1468-1331.2012.03817.x
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Weissbach, A., Kasten, M., Grünewald, A., Bruggemann, N., Trillenberg, P., Klein, C., & Hagenah, J. (2013). Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia. Parkinsonism and Related Disorders, 19 (4), 422-5. doi:10.1016/j.parkreldis.2012.12.004
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Freimann, K., Zschiedrich, K., Bruggemann, N., Grünewald, A., Pawlack, H., Hagenah, J., Lohmann, K., Klein, C., & Westenberger, A. (2013). Mortalin mutations are not a frequent cause of early-onset Parkinson disease. Neurobiology of Aging, 34 (11), 2694.e19-20. doi:10.1016/j.neurobiolaging.2013.05.021
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Wortmann, S. B., Vaz, F. M., Gardeitchik, T., Vissers, L. E. L. M., Renkema, G. H., Schuurs-Hoeijmakers, J. H. M., Kulik, W., Lammens, M., Christin, C., Kluijtmans, L. A. J., Rodenburg, R. J., Nijtmans, L. G. J., Grünewald, A., Klein, C., Gerhold, J. M., Kozicz, T., van Hasselt, P. M., Harakalova, M., Kloosterman, W., ... de Brouwer, A. P. M. (2012). Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nature Genetics, 44 (7), 797-802. doi:10.1038/ng.2325
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Schmidt, A., Kumar, K. R., Redyk, K., Grünewald, A., Leben, M., Munchau, A., Sue, C. M., Hagenah, J., Hartmann, H., Lohmann, K., Christen, H.-J., & Klein, C. (2012). Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations. Archives of Neurology, 69 (5), 668-70. doi:10.1001/archneurol.2012.187
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Grünewald, A.* , Arns, B.* , Seibler, P., Rakovic, A., Munchau, A., Ramirez, A., Sue, C. M., & Klein, C. (2012). ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiology of Aging, 33 (8), 1843.e1-7. doi:10.1016/j.neurobiolaging.2011.12.035
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* These authors have contributed equally to this work.

Abramov, A. Y., Gegg, M., Grünewald, A., Wood, N. W., Klein, C., & Schapira, A. H. V. (2011). Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS ONE, 6 (10), 25622. doi:10.1371/journal.pone.0025622
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Rakovic, A.* , Grünewald, A.* , Voges, L., Hofmann, S., Orolicki, S., Lohmann, K., & Klein, C. (2011). PINK1-interacting proteins: Proteomic analysis of overexpressed PINK1. Parkinsons Dis, 2011, 153979. doi:10.4061/2011/153979
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* These authors have contributed equally to this work.

Rakovic, A.* , Grünewald, A.* , Kottwitz, J., Bruggemann, N., Pramstaller, P. P., Lohmann, K., & Klein, C. (2011). Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS ONE, 6 (3), 16746. doi:10.1371/journal.pone.0016746
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* These authors have contributed equally to this work.

Kumar, K. R., Djarmati-Westenberger, A., & Grünewald, A. (2011). Genetics of Parkinson's disease. Seminars in Neurology, 31 (5), 433-40. doi:10.1055/s-0031-1299782
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Arif, B., Grünewald, A., Fatima, A., Ramirez, A., Ali, A., Bruggemann, N., Wurfel, J., Rolfs, A., Lohmann, K., Malik, A., Klein, C., & Naz, S. (2011). An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech. Movement Disorders, 26 (12), 2279-83. doi:10.1002/mds.23860
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Grünewald, A., Voges, L., Rakovic, A., Kasten, M., Vandebona, H., Hemmelmann, C., Lohmann, K., Orolicki, S., Ramirez, A., Schapira, A. H. V., Pramstaller, P. P., Sue, C. M., & Klein, C. (2010). Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS ONE, 5 (9), 12962. doi:10.1371/journal.pone.0012962
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Rakovic, A., Grünewald, A., Seibler, P., Ramirez, A., Kock, N., Orolicki, S., Lohmann, K., & Klein, C. (2010). Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Human Molecular Genetics, 19 (16), 3124-37. doi:10.1093/hmg/ddq215
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Grünewald, A., Gegg, M. E., Taanman, J.-W., King, R. H., Kock, N., Klein, C., & Schapira, A. H. V. (2009). Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Experimental Neurology, 219 (1), 266-73. doi:10.1016/j.expneurol.2009.05.027
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Grünewald, A., Djarmati, A., Lohmann-Hedrich, K., Farrell, K., Zeller, J. A., Allert, N., Papengut, F., Petersen, B., Fung, V., Sue, C. M., O'Sullivan, D., Mahant, N., Kupsch, A., Chuang, R. S., Wiegers, K., Pawlack, H., Hagenah, J., Ozelius, L. J., Stephani, U., ... Klein, C. (2008). Myoclonus-dystonia: significance of large SGCE deletions. Human Mutation, 29 (2), 331-2. doi:10.1002/humu.9521
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Brueggemann, N., Odin, P., Grünewald, A., Tadic, V., Hagenah, J., Seidel, G., Lohmann, K., Klein, C., & Djarmati, A. (2008). Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease. Neurology, 71 (16), 1294; author reply 1294. doi:10.1212/01.wnl.0000338439.00992.c7
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Paus, S., Grünewald, A., Klein, C., Knapp, M., Zimprich, A., Janetzky, B., Moller, J. C., Klockgether, T., & Wullner, U. (2008). The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease. Movement Disorders, 23 (4), 599-602. doi:10.1002/mds.21901
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Grünewald, A., Breedveld, G. J., Lohmann-Hedrich, K., Rohe, C. F., Konig, I. R., Hagenah, J., Vanacore, N., Meco, G., Antonini, A., Goldwurm, S., Lesage, S., Durr, A., Binkofski, F., Siebner, H., Munchau, A., Brice, A., Oostra, B. A., Klein, C., & Bonifati, V. (2007). Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis. Neurogenetics, 8 (2), 103-9. doi:10.1007/s10048-006-0072-y
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Djarmati, A.* , Guzvic, M.* , Grünewald, A., Lang, A. E., Pramstaller, P. P., Simon, D. K., Kaindl, A. M., Vieregge, P., Nygren, A. O. H., Beetz, C., Hedrich, K., & Klein, C. (2007). Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Movement Disorders, 22 (12), 1708-14. doi:10.1002/mds.21370
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* These authors have contributed equally to this work.

Orth, M., Djarmati, A., Baumer, T., Winkler, S., Grünewald, A., Lohmann-Hedrich, K., Kabakci, K., Hagenah, J., Klein, C., & Munchau, A. (2007). Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene. Movement Disorders, 22 (14), 2090-6. doi:10.1002/mds.21674
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Hedrich, K., Hagenah, J., Djarmati, A., Hiller, A., Lohnau, T., Lasek, K., Grünewald, A., Hilker, R., Steinlechner, S., Boston, H., Kock, N., Schneider-Gold, C., Kress, W., Siebner, H., Binkofski, F., Lencer, R., Munchau, A., & Klein, C. (2006). Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Archives of neurology, 63 (6), 833-8. doi:10.1001/archneur.63.6.833
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Klein, C., Grünewald, A., & Hedrich, K. (2006). Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology, 66 (7), 1129-30; author reply 1129-30. doi:10.1212/01.wnl.0000220157.81513.85
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