Reference : Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
Scientific journals : Article
Human health sciences : Neurology
Systems Biomedicine
http://hdl.handle.net/10993/49400
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
English
Domenighetti, Cloé [> >]
Sugier, Pierre-Emmanuel [> >]
Ashok Kumar Sreelatha, Ashwin [> >]
Schulte, Claudia [> >]
Grover, Sandeep [> >]
Mohamed, Océane [> >]
Portugal, Berta [> >]
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Bobbili, Dheeraj Reddy mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Radivojkov-Blagojevic, Milena [> >]
Lichtner, Peter [> >]
Singleton, Andrew B. [> >]
Hernandez, Dena G. [> >]
Edsall, Connor [> >]
Mellick, George D. [> >]
Zimprich, Alexander [> >]
Pirker, Walter [> >]
Rogaeva, Ekaterina [> >]
Lang, Anthony E. [> >]
Koks, Sulev [> >]
Taba, Pille [> >]
Lesage, Suzanne [> >]
Brice, Alexis [> >]
Corvol, Jean-Christophe [> >]
Chartier-Harlin, Marie-Christine [> >]
Mutez, Eugénie [> >]
Brockmann, Kathrin [> >]
Deutschländer, Angela B. [> >]
Hadjigeorgiou, Georges M. [> >]
Dardiotis, Efthimos [> >]
Stefanis, Leonidas [> >]
Simitsi, Athina Maria [> >]
Valente, Enza Maria [> >]
Petrucci, Simona [> >]
Duga, Stefano [> >]
Straniero, Letizia [> >]
Zecchinelli, Anna [> >]
Pezzoli, Gianni [> >]
Brighina, Laura [> >]
Ferrarese, Carlo [> >]
Annesi, Grazia [> >]
Quattrone, Andrea [> >]
Gagliardi, Monica [> >]
Matsuo, Hirotaka [> >]
Kawamura, Yusuke [> >]
Hattori, Nobutaka [> >]
Nishioka, Kenya [> >]
Chung, Sun Ju [> >]
Kim, Yun Joong [> >]
Kolber, Pierre [> >]
van de Warrenburg, Bart P. C. [> >]
Bloem, Bastiaan R. [> >]
Aasly, Jan [> >]
Toft, Mathias [> >]
Pihlstrøm, Lasse [> >]
Correia Guedes, Leonor [> >]
Ferreira, Joaquim J. [> >]
Bardien, Soraya [> >]
Carr, Jonathan [> >]
Tolosa, Eduardo [> >]
Ezquerra, Mario [> >]
Pastor, Pau [> >]
Diez-Fairen, Monica [> >]
Wirdefeldt, Karin [> >]
Pedersen, Nancy L. [> >]
Ran, Caroline [> >]
Belin, Andrea C. [> >]
Puschmann, Andreas [> >]
Hellberg, Clara [> >]
Clarke, Carl E. [> >]
Morrison, Karen E. [> >]
Tan, Manuela [> >]
Krainc, Dimitri [> >]
Burbulla, Lena F. [> >]
Farrer, Matt J. [> >]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Gasser, Thomas [> >]
Sharma, Manu [> >]
Elbaz, Alexis [> >]
Genetics, The Comprehensive Unbiased Risk Factor Assessment For [> >]
Consortium, Environment In Parkinson S Disease Courage-P. D. [> >]
8-Jan-2022
Movement Disorders
John Wiley & Sons
Yes (verified by ORBilu)
International
0885-3185
1531-8257
Hoboken
NY
[en] dairy intake ; Parkinson's disease ; Mendelian randomization
[en] Abstract Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95 confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Fonds National de la Recherche - FnR ; JPND Courage-PD
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/49400
10.1002/mds.28902
https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.28902
FnR ; FNR11264123 > Rejko Krüger > NCER-PD > Ncer-pd > 01/01/2015 > 30/11/2020 > 2015

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