Article (Scientific journals)
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
Domenighetti, Cloé; Sugier, Pierre-Emmanuel; Ashok Kumar Sreelatha, Ashwin et al.
2022In Movement Disorders
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Keywords :
dairy intake; Parkinson's disease; Mendelian randomization
Abstract :
[en] Abstract Background Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95 confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Neurology
Author, co-author :
Domenighetti, Cloé
Sugier, Pierre-Emmanuel
Ashok Kumar Sreelatha, Ashwin
Schulte, Claudia
Grover, Sandeep
Mohamed, Océane
Portugal, Berta
MAY, Patrick  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
BOBBILI, Dheeraj Reddy ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core
Radivojkov-Blagojevic, Milena
Lichtner, Peter
Singleton, Andrew B.
Hernandez, Dena G.
Edsall, Connor
Mellick, George D.
Zimprich, Alexander
Pirker, Walter
Rogaeva, Ekaterina
Lang, Anthony E.
Koks, Sulev
Taba, Pille
Lesage, Suzanne
Brice, Alexis
Corvol, Jean-Christophe
Chartier-Harlin, Marie-Christine
Mutez, Eugénie
Brockmann, Kathrin
Deutschländer, Angela B.
Hadjigeorgiou, Georges M.
Dardiotis, Efthimos
Stefanis, Leonidas
Simitsi, Athina Maria
Valente, Enza Maria
Petrucci, Simona
Duga, Stefano
Straniero, Letizia
Zecchinelli, Anna
Pezzoli, Gianni
Brighina, Laura
Ferrarese, Carlo
Annesi, Grazia
Quattrone, Andrea
Gagliardi, Monica
Matsuo, Hirotaka
Kawamura, Yusuke
Hattori, Nobutaka
Nishioka, Kenya
Chung, Sun Ju
Kim, Yun Joong
Kolber, Pierre
van de Warrenburg, Bart P. C.
Bloem, Bastiaan R.
Aasly, Jan
Toft, Mathias
Pihlstrøm, Lasse
Correia Guedes, Leonor
Ferreira, Joaquim J.
Bardien, Soraya
Carr, Jonathan
Tolosa, Eduardo
Ezquerra, Mario
Pastor, Pau
Diez-Fairen, Monica
Wirdefeldt, Karin
Pedersen, Nancy L.
Ran, Caroline
Belin, Andrea C.
Puschmann, Andreas
Hellberg, Clara
Clarke, Carl E.
Morrison, Karen E.
Tan, Manuela
Krainc, Dimitri
Burbulla, Lena F.
Farrer, Matt J.
KRÜGER, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Gasser, Thomas
Sharma, Manu
Elbaz, Alexis
Genetics, The Comprehensive Unbiased Risk Factor Assessment For
Consortium, Environment In Parkinson S Disease Courage-P. D.
More authors (71 more) Less
External co-authors :
yes
Language :
English
Title :
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
Publication date :
08 January 2022
Journal title :
Movement Disorders
ISSN :
1531-8257
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
FNR11264123 - Ncer-pd, 2015 (01/01/2015-30/11/2020) - Rejko Krüger
Funders :
FNR - Fonds National de la Recherche [LU]
JPND Courage-PD
Available on ORBilu :
since 09 January 2022

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