Reference : The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/48858
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
English
Badanjak, Katja mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology]
Fixemer, Sonja mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling]
Smajic, Semra mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling]
Grünewald, Anne mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology]
2021
International journal of molecular sciences
22
9
Yes (verified by ORBilu)
1422-0067
1422-0067
[en] Animals ; Brain/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Humans ; Inflammation/pathology ; Microglia/metabolism/physiology ; Nerve Degeneration/pathology ; Neuroimmunomodulation/immunology/physiology ; Neurons/metabolism ; Neuroprotection ; Oxidative Stress ; Parkinson Disease/immunology/metabolism/physiopathology ; alpha-Synuclein ; Parkinson’s disease ; animal models ; brain ; iPSC ; microglia ; neurodegeneration ; neuroinflammation
[en] With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD.
http://hdl.handle.net/10993/48858
FnR ; FNR9631103 > Anne Grünewald > Model IPD > Modelling Idiopathic Parkinson’S Disease-associated Somatic Variation In Dopaminergic Neurons > 01/01/2016 > 31/12/2022 > 2015

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