Article (Scientific journals)
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
Badanjak, Katja; Fixemer, Sonja; Smajic, Semra et al.
2021In International Journal of Molecular Sciences, 22 (9)
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Keywords :
Animals; Brain/metabolism; Cytokines/metabolism; Disease Models, Animal; Dopamine/metabolism; Dopaminergic Neurons/metabolism; Humans; Inflammation/pathology; Microglia/metabolism/physiology; Nerve Degeneration/pathology; Neuroimmunomodulation/immunology/physiology; Neurons/metabolism; Neuroprotection; Oxidative Stress; Parkinson Disease/immunology/metabolism/physiopathology; alpha-Synuclein; Parkinson’s disease; animal models; brain; iPSC; microglia; neurodegeneration; neuroinflammation
Abstract :
[en] With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Badanjak, Katja ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
Fixemer, Sonja ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling
Smajic, Semra ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
Skupin, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling
Grünewald, Anne  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology
External co-authors :
no
Language :
English
Title :
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
Publication date :
2021
Journal title :
International Journal of Molecular Sciences
ISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
22
Issue :
9
Peer reviewed :
Peer Reviewed verified by ORBi
FnR Project :
FNR9631103 - Modelling Idiopathic Parkinson'S Disease-associated Somatic Variation In Dopaminergic Neurons, 2015 (01/01/2016-31/12/2022) - Anne Grünewald
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