Reference : Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight l...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Systems Biomedicine
http://hdl.handle.net/10993/45951
Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome.
English
Noor, Fozia mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Experimental Neurobiology >]
Biemann, Ronald []
Roomp, Kirsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core >]
Schneider, Jochen mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Medical Translational Research >]
Isermann, B []
20-Oct-2020
Scientific Reports
Nature Publishing Group
10
1
17855
Yes (verified by ORBilu)
International
2045-2322
London
United Kingdom
[en] Lifestyle-induced weight loss is regarded as an efficient therapy to reverse metabolic syndrome (MetS) and to prevent disease progression. The objective of this study was to investigate whether lifestyle-induced weight loss modulates gene expression in circulating monocytes. We analyzed and compared gene expression in monocytes (CD14+ cells) and subcutaneous adipose tissue biopsies by unbiased mRNA profiling. Samples were obtained before and after diet-induced weight loss in well-defined male individuals in a prospective controlled clinical trial (ICTRP Trial Number: U1111-1158-3672). The BMI declined significantly (- 12.6%) in the treatment arm (N = 39) during the 6-month weight loss intervention. This was associated with a significant reduction in hsCRP (- 45.84%) and circulating CD14+ cells (- 21.0%). Four genes were differentially expressed (DEG's) in CD14+ cells following weight loss (ZRANB1, RNF25, RB1CC1 and KMT2C). Comparative analyses of paired CD14+ monocytes and subcutaneous adipose tissue samples before and after weight loss did not identify common genes differentially regulated in both sample types. Lifestyle-induced weight loss is associated with specific changes in gene expression in circulating CD14+ monocytes, which may affect ubiquitination, histone methylation and autophagy
http://hdl.handle.net/10993/45951
10.1038/s41598-020-74973-2

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