Reference : Common diseases alter the physiological age-related blood microRNA profile.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/45365
Common diseases alter the physiological age-related blood microRNA profile.
English
Fehlmann, Tobias [Saarland University > Clinical Bioinformatics]
Lehallier, Benoit [Stanford University > Department of Neurology and Neurological Sciences]
Schaum, Nicholas [Stanford University > Department of Neurology and Neurological Sciences]
Hahn, Oliver [Stanford University > Department of Neurology and Neurological Sciences]
Kahraman, Mustafa [> >]
Li, Yongping [> >]
Grammes, Nadja [> >]
Geffers, Lars [Luxembourg Institute of Health - LIH]
Backes, Christina [> >]
Balling, Rudolf mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kern, Fabian [> >]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Lammert, Frank [> >]
Ludwig, Nicole [> >]
Meder, Benjamin [> >]
Fromm, Bastian [> >]
Maetzler, Walter [> >]
Berg, Daniela [> >]
Brockmann, Kathrin [> >]
Deuschle, Christian [> >]
von Thaler, Anna-Katharina [> >]
Eschweiler, Gerhard W. [> >]
Milman, Sofiya [> >]
Barziliai, Nir [> >]
Reichert, Matthias [> >]
Wyss-Coray, Tony [Stanford University > Department of Neurology and Neurological Sciences]
Meese, Eckart [> >]
Keller, Andreas [Saarland University > Clinical Bioinformatics]
24-Nov-2020
Nature communications
11
1
5958
Yes (verified by ORBilu)
International
2041-1723
2041-1723
[en] Adult ; Aged ; Aging/genetics/metabolism ; Biomarkers ; Disease/genetics ; Female ; Gene Expression ; Gene Expression Profiling ; Healthy Aging/genetics ; Humans ; Male ; MicroRNAs/blood/genetics ; RNA-Seq/methods
[en] Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5' mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/45365
10.1038/s41467-020-19665-1
https://www.nature.com/articles/s41467-020-19665-1#article-info
FnR ; FNR6682797 > Rejko Krüger > Endophenotypes in Neurodegeneration > Comprehensive assessment of endophenotypes in neurodegenerative diseases - translating impaired molecular signalling pathways into novel therapeutic strategies for Parkinson’s disease > 01/06/2014 > 31/05/2019 > 2013

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