Reference : Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/44280
Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells
English
Walbrecq, Geoffroy [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Margue, Christiane mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Behrmann, Iris mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Kreis, Stephanie mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
17-Jul-2020
International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)
Yes (verified by ORBilu)
International
1661-6596
1422-0067
Basel
Switzerland
[en] extracellular vesicle ; cancer ; hypoxia ; TME ; immunity ; biomarker
[en] Hypoxia is a common hallmark of solid tumors and is associated with aggressiveness, metastasis and poor outcome. Cancer cells under hypoxia undergo changes in metabolism and there is an intense crosstalk between cancer cells and cells from the tumor microenvironment. This cross talk is facilitated by small extracellular vesicles (sEVs; diameter between 30 and 200 nm), including exosomes and microvesicles, which carry a cargo of proteins, mRNA, ncRNA and other biological molecules. Hypoxia is known to increase secretion of sEVs and has an impact on the composition of the cargo. This sEV-mediated crosstalk ultimately leads to various biological effects in the proximal tumor microenvironment but also at distant, future metastatic sites. In this review, we discuss the changes induced by hypoxia on sEV secretion and their cargo as well as their effects on the behaviour and metabolism of cancer cells, the tumor microenvironment and metastatic events.
Department of Life Sciences and Medicine
Fondation Cancer
SecMelPro
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/44280
10.3390/ijms21145071

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Walbrecq et al., 2020.pdfPublisher postprint1.75 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.