Article (Scientific journals)
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?
Ternes, Dominik; Karta, Jessica; Tsenkova, Mina et al.
2020In Trends in Microbiology
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Abstract :
[en] Mounting evidence from metagenomic analyses suggests that a state of pathological microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer. Several bacterial taxa have been identified of which representative isolate cultures interact with human cancer cells in vitro and trigger disease path-ways in animal models. However, how the complex interrelationships in dysbiotic communities may be involved in cancer pathogenesis remains a crucial question.Here, we provide a survey of current knowledge of the gut microbiome in colorectal cancer. Moving beyond observational studies, we outline new experimental approaches for gaining ecosystem-level mechanistic understanding of the gut microbiome’s role in cancer pathogenesis
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Ternes, Dominik ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Karta, Jessica ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Tsenkova, Mina ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Wilmes, Paul ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Haan, Serge ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?
Publication date :
13 February 2020
Journal title :
Trends in Microbiology
ISSN :
1878-4380
Publisher :
Elsevier Trends Journals, Cambridge, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
FnR Project :
FNR10404093 - Non-invasive Microbiome-derived Multi-omic Biomarkers For Early-stage Colorectal Cancer Detection, 2015 (01/01/2016-30/04/2019) - Paul Wilmes
Available on ORBilu :
since 04 March 2020

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