Reference : Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/42723
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?
English
Ternes, Dominik mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Karta, Jessica mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Tsenkova, Mina mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Haan, Serge mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Letellier, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
13-Feb-2020
Trends in Microbiology
Elsevier Trends Journals
Yes (verified by ORBilu)
International
0966-842X
1878-4380
Cambridge
United Kingdom
[en] Mounting evidence from metagenomic analyses suggests that a state of pathological microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer. Several bacterial taxa have been identified of which representative isolate cultures interact with human cancer cells in vitro and trigger disease path-ways in animal models. However, how the complex interrelationships in dysbiotic communities may be involved in cancer pathogenesis remains a crucial question.Here, we provide a survey of current knowledge of the gut microbiome in colorectal cancer. Moving beyond observational studies, we outline new experimental approaches for gaining ecosystem-level mechanistic understanding of the gut microbiome’s role in cancer pathogenesis
Researchers
http://hdl.handle.net/10993/42723
10.1016/j.tim.2020.01.001
FnR ; FNR10404093 > Paul Wilmes > microCancer > Non-invasive microbiome-derived multi-omic biomarkers for early-stage colorectal cancer detection > 01/01/2016 > 30/04/2019 > 2015

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