Article (Scientific journals)
Many ways to resistance: How melanoma cells evade targeted therapies
Kozar, Ines; Margue, Christiane; Rothengatter, Sonja et al.
2019In Biochimica et Biophysica Acta - Reviews on Cancer, 1871 (2), p. 313-322
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Keywords :
melanoma; BRAF; targeted therapies
Abstract :
[en] Melanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment. A number of molecular mechanisms underlying this resistant phenotype have already been elucidated. In this review, we summarise currently available treatment options for metastatic melanoma and the known resistance mechanisms to targeted therapies. A focus will be placed on “phenotype switching” as a mechanism and driver of drug resistance, together with an overview of novel approaches to circumvent resistance. A large body of recent data and literature suggests that tumour progression and phenotype switching could be better controlled and development of resistance prevented or at least delayed, by combining drugs targeting fast- and slow-proliferating cells.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Kozar, Ines ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Margue, Christiane  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Rothengatter, Sonja
Haan, Claude ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Kreis, Stephanie ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
yes
Language :
English
Title :
Many ways to resistance: How melanoma cells evade targeted therapies
Publication date :
15 February 2019
Journal title :
Biochimica et Biophysica Acta - Reviews on Cancer
ISSN :
0304-419X
Publisher :
Elsevier
Volume :
1871
Issue :
2
Pages :
313-322
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 20 February 2019

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