Article (Scientific journals)
Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project.
Winterer, G.; Androsova, Ganna; Bender, O. et al.
2018In European Psychiatry, 50, p. 34-39
Peer Reviewed verified by ORBi
 

Files


Full Text
Winterer et al. - 2018 - Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog proje.pdf
Author preprint (837.49 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Molecular biomarkers; Multivariate prediction algorithm; Neuroimaging; Postoperative cognitive dysfunction; Postoperative delirium
Abstract :
[en] Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions - particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost-benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation.
Disciplines :
Anesthesia & intensive care
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Winterer, G.
Androsova, Ganna ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Bender, O.
Boraschi, D.
Borchers, F.
Dschietzig, T. B.
Feinkohl, I.
Fletcher, P.
Gallinat, J.
Hadzidiakos, D.
Haynes, J. D.
Heppner, F.
Hetzer, S.
Hendrikse, J.
Ittermann, B.
Kant, I. M. J.
Kraft, A.
Krannich, A.
Krause, Roland  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kuhn, S.
Lachmann, G.
van Montfort, S. J. T.
Muller, A.
Nurnberg, P.
Ofosu, K.
Pietsch, M.
Pischon, T.
Preller, J.
Renzulli, E.
Scheurer, K.
Schneider, Reinhard ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Slooter, A. J. C.
Spies, C.
Stamatakis, E.
Volk, H. D.
Weber, S.
Wolf, A.
Yurek, F.
Zacharias, N.
More authors (29 more) Less
External co-authors :
yes
Language :
English
Title :
Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project.
Publication date :
2018
Journal title :
European Psychiatry
ISSN :
1778-3585
Publisher :
Elsevier Masson, Paris, France
Volume :
50
Pages :
34-39
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
European Projects :
FP7 - 602461 - BIOCOG - Biomarker Development for Postoperative Cognitive Impairment in the Elderly
Funders :
CE - Commission Européenne [BE]
Commentary :
Copyright (c) 2017. Published by Elsevier Masson SAS.
Available on ORBilu :
since 20 November 2018

Statistics


Number of views
134 (6 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
43
Scopus citations®
without self-citations
9
OpenCitations
 
36
WoS citations
 
40

Bibliography


Similar publications



Contact ORBilu