Article (Scientific journals)
CaSiAn: a Calcium Signaling Analyzer tool
Moein, Mahsa; Grzyb, Kamil; Gonçalves Martins, Teresa et al.
2018In Bioinformatics, 1, p. 3
Peer reviewed
 

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Keywords :
calcium signalling; data analysis
Abstract :
[en] Ca2þ is a central second messenger in eukaryotic cells that regulates many cellular proc- esses. Recently, we have indicated that typical Ca2þ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statis- tics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2þ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Moein, Mahsa ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Grzyb, Kamil ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Gonçalves Martins, Teresa
Komoto, Shinya
Peri, Francesca
Crawford, Alexander Dettmar ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Fouquier d’Herouel, Aymeric
Skupin, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
CaSiAn: a Calcium Signaling Analyzer tool
Publication date :
2018
Journal title :
Bioinformatics
Publisher :
Oxford University Press
Volume :
1
Pages :
3
Peer reviewed :
Peer reviewed
Focus Area :
Systems Biomedicine
Available on ORBilu :
since 09 July 2018

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