Article (Scientific journals)
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
Jung, Paul; Zhang, Zhi; Paczia, Nicole et al.
2018In npj Aging and Mechanisms of Disease, 4 (3)
Peer Reviewed verified by ORBi
 

Files


Full Text
Jung_et_al-2018-npj_Aging_and_Mechanisms_of_Disease.pdf
Publisher postprint (1.24 MB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
yeast; aging; natural variation; RIM15; SER1; QTL
Abstract :
[en] Aging is a complex trait of broad scientific interest, especially because of its intrinsic link with common human diseases. Pioneering work on aging-related mechanisms has been made in Saccharomyces cerevisiae, mainly through the use of deletion collections isogenic to the S288c reference strain. In this study, using a recently published high-throughput approach, we quantified chronological life span (CLS) within a collection of 58 natural strains across seven different conditions. We observed a broad aging variability suggesting the implication of diverse genetic and environmental factors in chronological aging control. Two major Quantitative Trait Loci (QTLs) were identified within a biparental population obtained by crossing two natural isolates with contrasting aging behavior. Detection of these QTLs was dependent upon the nature and concentration of the carbon sources available for growth. In the first QTL, the RIM15 gene was identified as major regulator of aging under low glucose condition, lending further support to the importance of nutrient-sensing pathways in longevity control under calorie restriction. In the second QTL, we could show that the SER1 gene, encoding a conserved aminotransferase of the serine synthesis pathway not previously linked to aging, is causally associated with CLS regulation, especially under high glucose condition. These findings hint toward a new mechanism of life span control involving a trade-off between serine synthesis and aging, most likely through modulation of acetate and trehalose metabolism. More generally it shows that genetic linkage studies across natural strains represent a promising strategy to further unravel the molecular basis of aging.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Enzymology & Metabolism (Linster Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
ULHPC - University of Luxembourg: High Performance Computing
Disciplines :
Genetics & genetic processes
Biochemistry, biophysics & molecular biology
Author, co-author :
Jung, Paul ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Zhang, Zhi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Paczia, Nicole ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Jäger, Christian  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ignac, Tomasz
May, Patrick  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Linster, Carole  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
Publication date :
12 March 2018
Journal title :
npj Aging and Mechanisms of Disease
ISSN :
2056-3973
Publisher :
Nature Partner Journals, London, United Kingdom
Volume :
4
Issue :
3
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
FNR11339953 - Completing The Metabolic Map Around The Oncometabolite D-2-hydroxyglutarate, 2016 (01/11/2016-31/03/2019) - Nicole Paczia
Funders :
FNR (INTER/BMBF/13/04), e:Med BMBF
FNR (MitoPD)
plan Technologies de la Santé
FNR (NCER-PD)
Available on ORBilu :
since 13 March 2018

Statistics


Number of views
181 (24 by Unilu)
Number of downloads
71 (4 by Unilu)

Scopus citations®
 
18
Scopus citations®
without self-citations
17
OpenCitations
 
20
WoS citations
 
20

Bibliography


Similar publications



Contact ORBilu