  | HEINS MARROQUIN, U., SINGH, R., PERATHONER, S., GAVOTTO, F., Ruiz, C. M., PATRASKAKI, M., Gomez-Giro, G., Borgmann, F. K., Meyer, M., Carpentier, A., WARMOES, M. O., JÄGER, C., MITTELBRONN, M., SCHWAMBORN, J. C., CORDERO MALDONADO, M. L., CRAWFORD, A., SCHYMANSKI, E., & LINSTER, C. (2023). CLN3 deficiency leads to neurological and metabolic perturbations during early development. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/57737. doi:10.1101/2023.03.17.533107 |
 | Soriano-Baguet, L., Grusdat, M., Kurniawan, H., Benzarti, M., Binsfeld, C., Ewen, A., LONGWORTH, J., Bonetti, L., Guerra, L., Franchina, D. G., Kobayashi, T., Horkova, V., Verschueren, C., Helgueta, S., GERARD, D., More, T. H., Henne, A., Dostert, C., Farinelle, S., ... Brenner, D. (2023). Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions. Cell Reports. doi:10.1016/j.celrep.2023.112153  Peer Reviewed verified by ORBi |
 | Trezzi, J.-P., AHO, V., Jäger, C., Schade, S., Janzen, A., HICKL, O., Kunath, B., THOMAS, M., SCHMIT, K., GARCIA, P., SCIORTINO, A., Martin-Gallausiaux, C., HALDER, R., Huarte, O. U., HEURTAUX, T., Heins-Marroquin, U., Gomez-Giro, G., Weidenbach, K., DELACOUR, L., ... WILMES, P. (2022). An archaeal compound as a driver of Parkinson’s disease pathogenesis. (1). ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51987. doi:10.21203/rs.3.rs-1827631/v1 |
 | Vausort, M., Niedolistek, M., Lumley, A. I., Oknińska, M., Paterek, A., Mączewski, M., DONG, X., Jäger, C., LINSTER, C., Leszek, P., & DEVAUX, Y. (2022). Regulation of N6-Methyladenosine after Myocardial Infarction. Cells, 11 (15), 2271. doi:10.3390/cells11152271 Peer Reviewed verified by ORBi |
 | Kiweler, N., Delbrouck, C., POZDEEV, V., Neises, L., Soriano-Bague, L., Eiden, K., Xian, F., Benzarti, M., Haase, L., KONCINA, E., SCHMOETTEN, M., JÄGER, C., Zaeem Noman, M., Vazquez, A., Janji, B., DITTMAR, G., BRENNER, D., LETELLIER, E., & Meiser, J. (2022). Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis. Nature Communications. doi:10.1038/s41467-022-30363-y Peer Reviewed verified by ORBi |
 | DE SAEDELEER, B., MALABIRADE, A., RAMIRO GARCIA, J., HABIER, J., TREZZI, J.-P., Peters, S., DAUJEUMONT, A., HALDER, R., Jäger, C., BUSI, S. B., MAY, P., Oertel, W., Mollenhauer, B., LACZNY, C. C., Hettich, R., & WILMES, P. (2021). Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics. ISME Communications. doi:10.1038/s43705-021-00078-0 Peer Reviewed verified by ORBi |
 | THOMAS, M., Gui, Y., GARCIA, P., Karout, M., GOMEZ RAMOS, B., JÄGER, C., Michelucci, A., GAIGNEAUX, A., Kollmus, H., Centeno, A., Schughart, K., Balling, R., Mittelbronn, M., Nadeau, J. H., SAUTER, T., Williams, R. W., SINKKONEN, L., & BUTTINI, M. (2021). Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice. Genes, Brain, and Behavior. doi:10.1111/gbb.12769 Peer Reviewed verified by ORBi |
  | JARAZO, J., BARMPA, K., Modamio, J., SARAIVA, C., SABATÉ SOLER, S., ROSETY, I., Griesbeck, A., Skwirblies, F., Zaffaroni, G., SMITS, L., Su, J., Arias-Fuenzalida, Walter, J., GOMEZ GIRO, G., Monzel, A., Qing, X., VITALI, A., CRUCIANI, G., BOUSSAAD, I., ... SCHWAMBORN, J. C. (2021). Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment. Movement Disorders. doi:10.1002/mds.28810 Peer Reviewed verified by ORBi |
 | Anso, I., Basso, L. G. M., Wang, L., Marina, A., Páez-Pérez, E. D., Jäger, C., GAVOTTO, F., Tersa, M., PERRONE, S., Contreras, F.-X., Prandi, J., Gilleron, M., LINSTER, C., Corzana, F., Lowary, T. L., Trastoy, B., & Guerin, M. E. (2021). Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Science Advances, 7 (42). doi:10.1126/sciadv.abj4565 Peer Reviewed verified by ORBi |
 | Herold, M., MARTINEZ ARBAS, S., Narayanasamy, S., Sheik, A. R., Kleine-Borgmann, L. A. K., LEBRUN, L., KUNATH, B., Roume, H., Bessarab, I., Williams, R. B. H., Gillece, J. D., Schupp, J. M., Keim, P. S., Jäger, C., Hoopman, M. R., Moritz, R. L., Ye, Y., Li, S., Tang, H., ... WILMES, P. (2020). Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance. Nature Communications. doi:10.1038/s41467-020-19006-2 Peer Reviewed verified by ORBi |
 | Kurniawan, H., Franchina, D. G., GUERRA, L., BONETTI, L., - Baguet, L. S., Grusdat, M., Schlicker, L., Hunewald, O., Dostert, C., Merz, M. P., Binsfeld, C., Duncan, G. S., FARINELLE, S., Nonnenmacher, Y., Haight, J., Das Gupta, D., Ewen, A., Taskesen, R., HALDER, R., ... BRENNER, D. (05 May 2020). Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. Cell Metabolism, 31 (5), 920--936.e7. doi:10.1016/j.cmet.2020.03.004 Peer reviewed |
 | GOMEZ GIRO, G., Arias-Fuenzalida, J., JARAZO, J., Zeuschner, D., ALI, M., Possemis, N., BOLOGNIN, S., HALDER, R., Jäger, C., Kuper, W., van Hasselt, P., Zaehres, H., DEL SOL MESA, A., van der Putten, H., Schoeler, H., & SCHWAMBORN, J. C. (2020). Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathologica Communications. doi:10.1186/s40478-019-0871-7 Peer Reviewed verified by ORBi |
 | Greuel, A., TREZZI, J.-P., GLAAB, E., Ruppert, M. C., Maier, F., Jäger, C., Hodak, Z., Lohmann, K., Yilong, M., Eidelberg, D., Timmermann, L., Hiller, K., Tittgemeyer, M., Drzezga, A., Diederich, N., & Eggers, C. (2020). GBA variants in Parkinson’s disease: clinical, metabolomic and multimodal neuroimaging phenotypes. Movement Disorders, 35 (12), 2201-2210. doi:10.1002/mds.28225 Peer Reviewed verified by ORBi |
 | Dethlefsen, S., Jäger, C., Klockgether, J., Schomburg, D., & Tümmler, B. (2019). Metabolite profiling of the cold adaptation of Pseudomonas putida KT2440 and cold‐sensitive mutants. Environmental Microbiology Reports, 1758--2229.12793. doi:10.1111/1758-2229.12793 Peer Reviewed verified by ORBi |
 | GLAAB, E., TREZZI, J.-P., Greuel, A., Jäger, C., Hodak, Z., Drzezga, A., Timmermann, L., Tittgemeyer, M., Diederich, N. J., & Eggers, C. (2019). Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease. Neurobiology of Disease, 124 (1), 555-562. doi:10.1016/j.nbd.2019.01.003 Peer Reviewed verified by ORBi |
 | NICKELS, S., Walter, J., BOLOGNIN, S., GERARD, D., Jäger, C., Qing, X., Tisserand, J., JARAZO, J., Hemmer, K., Harms, A., HALDER, R., Lucarelli, P., Berger, E., ANTONY, P., GLAAB, E., Hankemeier, T., Klein, C., SAUTER, T., SINKKONEN, L., & SCHWAMBORN, J. C. (2019). Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism and Related Disorders. doi:10.1016/j.parkreldis.2019.09.018 Peer Reviewed verified by ORBi |
 | GLAAB, E., TREZZI, J.-P., Greuel, Jäger, C., HODAK, Z., Timmermann, L., Tittgemeyer, M., Diederich, N. J., & Eggers, C. (08 October 2018). Combining PET imaging and blood metabolomics data to improve machine learning models for Parkinson’s disease diagnosis [Poster presentation]. 2018 International Congress of the International Parkinson and Movement Disorders Society, Esch-sur-Alzette, Luxembourg. |
 | HEROLD, M., NARAYANASAMY, S., MARTINEZ ARBAS, S., MULLER, E., KLEINE-BORGMANN, A. L., LEBRUN, L., ROUME, H., SHEIK, A., Bessarab, I., Williams, R., Gillece, J., Schupp, J., Keim, P., Jäger, C., Hoopmann, M., Li, S., Tang, H., HEINTZ, A., MAY, P., ... WILMES, P. (August 2018). Integrated time-resolved multi-omics for understanding microbial niche ecology [Poster presentation]. 17th International Symposium on Microbial Ecology, Leipzig, Germany. |
 | JUNG, P., ZHANG, Z., PACZIA, N., Jäger, C., Ignac, T., MAY, P., & LINSTER, C. (12 March 2018). Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. npj Aging and Mechanisms of Disease, 4 (3). doi:10.1038/s41514-018-0022-6 Peer Reviewed verified by ORBi |
 | Krämer, L., Jäger, C., TREZZI, J.-P., Jacobs, D., & Hiller, K. (14 February 2018). Quantification of Stable Isotope Traces Close to Natural Enrichment in Human Plasma Metabolites Using Gas Chromatography-Mass Spectrometry. Metabolites, 8 (1), 15. doi:10.3390/metabo8010015 Peer Reviewed verified by ORBi |
 | TREZZI, J.-P., Greuel, A., GLAAB, E., Hodak, Z., Timmermann, L., Jäger, C., Diederich, N., & Eggers, C. (2018). Combining Metabolomics and Neuroimaging in mid-stage Parkinson’s Disease. A Proof of Concept for Cross-Fertilization. Neurology, 90 (15), 3066. Peer Reviewed verified by ORBi |
 | Meiser, J., Kraemer, L., Jäger, C., Madry, H., Link, A., Lepper, P. M., Hiller, K., & SCHNEIDER, J. (2018). Itaconic acid indicates cellular but not systemic immune system activation. Oncotarget, 9 (63). doi:10.18632/oncotarget.25956 Peer Reviewed verified by ORBi |
 | TREZZI, J.-P., Galozzi, S., Jäger, C., Barkovits, K., Brockmann, K., Maetzler, W., Berg, D., Marcus, K., Betsou, F., HILLER, K., & Mollenhauer, B. (2017). Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease: Early Parkinson'S CSF Metabolic Signature. Movement Disorders. doi:10.1002/mds.27132 Peer reviewed |
 | Hootman, K. C.* , TREZZI, J.-P.* , KRAEMER, L., Burwell, L. S., DONG, X., Guertin, K. A., Jäger, C., Stover, P. J., HILLER, K., & Cassano, P. A. (2017). Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1620079114 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., Jäger, C., Chen, Y., Pinkenburg, O., Camara, B., Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., ... Brenner, D. (18 April 2017). Glutathione Primes T Cell Metabolism for Inflammation. Immunity, 46 (4), 675-689. doi:10.1016/j.immuni.2017.03.019 Peer reviewed |
 | TREZZI, J.-P., Jäger, C., Galozzi, S., Barkovits, K., Marcus, K., Mollenhauer, B., & Hiller, K. (20 February 2017). Metabolic profiling of body fluids and multivariate data analysis. MethodsX, 4 (1), 95-103. doi:10.1016/j.mex.2017.02.004 Peer Reviewed verified by ORBi |
GREENHALGH, K., FRITZ, J., LETELLIER, E., RAMIRO GARCIA, J., HALDER, R., FRACHET BOUR, A., BAGINSKA, J., TERNES, D., Jäger, C., HAAN, S., & WILMES, P. (2017). A study of the molecular mechanisms underlying teh response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics [Poster presentation]. ISAPP conference. |
 | MAGNUSDOTTIR, S., HEINKEN, A. K., Kutt, L., RAVCHEEV, D., BAUER, E., NORONHA, A., GREENHALGH, K., Jäger, C., BAGINSKA, J., WILMES, P., FLEMING, R. M., & THIELE, I. (2016). Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota. Nature Biotechnology. doi:10.1038/nbt.3703 Peer Reviewed verified by ORBi |
 | GREENHALGH, K., FRITZ, J., LETELLIER, E., FRACHET BOUR, A., BAGINSKA, J., SHAH, P., DESAI, M., GLAAB, E., Jäger, C., HAAN, S., & WILMES, P. (June 2016). A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics [Poster presentation]. ISAPP conference. |
 | ANTONY, P., TALLAM, A., PERUMAL, T. M., Jäger, C., FRITZ, J., BALLING, R., DEL SOL MESA, A., MICHELUCCI, A., & Vallar, L. (2016). Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages. PLoS ONE. doi:10.1371/journal.pone.0149050 Peer Reviewed verified by ORBi |
 | Lorendeau, D., Rinaldi, G., Boon, R., Spincemaille, P., Metzger, K., Jäger, C., Christen, S., DONG, X., Kuenen, S., Voordeckers, K., Verstreken, P., Cassiman, D., Vermeersch, P., Verfaillie, C., HILLER, K., & Fendt, S.-M. (2016). Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Metabolic Engineering. doi:10.1016/j.ymben.2016.11.005 Peer reviewed |
Jäger, C., HILLER, K., & BUTTINI, M. (2016). Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry: Metabolic Profiling of Neurotransmitters by GC-MS. In J. Auwerx, S. L. Ackerman, S. D. Brown, M. J. Justice, ... J. Nadeau (Eds.), Current Protocols in Mouse Biology (pp. 333--342). Hoboken, NJ, USA, Unknown/unspecified: John Wiley Sons, Inc. doi:10.1002/cpmo.15 Peer reviewed |
 | Zhang, H., Badur, M. G., Divakaruni, A. S., Parker, S. J., Jäger, C., HILLER, K., Murphy, A. N., & Metallo, C. M. (2016). Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Reports, 16 (6), 1536--1547. doi:10.1016/j.celrep.2016.06.102 Peer Reviewed verified by ORBi |
 | SHAH, P., FRITZ, J., GLAAB, E., Desai, M. S., GREENHALGH, K., FRACHET BOUR, A., Niegowska, M., Estes, M., Jäger, C., Seguin-Devaux, C., Zenhausern, F., & WILMES, P. (2016). A microfluidics-based in vitro model of the gastrointestinal human-microbe interface. Nature Communications, 7, 11535. doi:10.1038/ncomms11535 Peer Reviewed verified by ORBi |
 | MEISER, J., DELCAMBRE, S., WEGNER, A., Jäger, C., GHELFI, J., FOUQUIER D'HÉROUËL, A., DONG, X., WEINDL, D., Stautner, C., NONNENMACHER, Y., MICHELUCCI, A., Popp, O., Giesert, F., Schildknecht, S., KRAEMER, L., Schneider, J. G., Woitalla, D., Wurst, W., SKUPIN, A., ... HILLER, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019 Peer Reviewed verified by ORBi |
 | WEINDL, D., WEGNER, A., Jäger, C., & HILLER, K. (10 April 2015). Isotopologue ratio normalization for non-targeted metabolomics. Journal of Chromatography. A, 1389, 112–119. doi:10.1016/j.chroma.2015.02.025 Peer Reviewed verified by ORBi |
 | Jäger, C.* , GLAAB, E.* , MICHELUCCI, A.* , Binz, T., Köglsberger, S., GARCIA, P., TREZZI, J.-P., GHELFI, J., BALLING, R., & BUTTINI, M. (2015). The Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury. American Journal of Pathology, 185 (6), 1699-1712. doi:10.1016/j.ajpath.2015.02.016 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | HILLJE, A.-L., Beckmann, E., PAVLOU, M. A., Jäger, C., PACHECO, M., SAUTER, T., SCHWAMBORN, J. C., & Lewejohann, L. (2015). The neural stem cell fate determinant TRIM32 regulates complex behavioral traits. Frontiers in Cellular Neuroscience. doi:10.3389/fncel.2015.00075 Peer Reviewed verified by ORBi |
 | WEGNER, A., WEINDL, D., Jäger, C., SAPCARIU, S., DONG, X., Stephanopoulos, G., & HILLER, K. (January 2014). Fragment Formula Calculator (FFC): Determination of chemical formulas for fragment ions in mass spectrometric data. Analytical Chemistry, 86 (4), 2221–2228. doi:10.1021/ac403879d Peer Reviewed verified by ORBi |
 | Poblete-Castro, I., Escapa, I. F., Jäger, C., Puchalka, J., Ming Chi Lam, C., Schomburg, D., Prieto, M. A., & Martins dos Santos, V. A. (2012). The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single-and multiple-nutrient-limited growth: Highlights from a multi-level omics approach. Microbial Cell Factories. doi:10.1186/1475-2859-11-34 Peer Reviewed verified by ORBi |
 | HILLER, K., Hangebrauk, J., Jäger, C., Spura, J., Schreiber, K., & Schomburg, D. (2009). MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis. Analytical Chemistry. doi:10.1021/ac802689c Peer Reviewed verified by ORBi |
