Reference : Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lob...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/32621
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
English
Androsova, Ganna* mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Krause, Roland* mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Borghei, Mojgansadat mailto [Université Libre de Bruxelles, Brussels, Belgium > Laboratory of Experimental Neurology]
Wassenaar, Merel mailto [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands]
Auce, Pauls mailto [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology > > ; The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom]
Avbersek, Andreja mailto [UCL Institute of Neurology, London, United Kingdom > Department of Clinical and Experimental Epilepsy]
Becker, Felicitas mailto [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
Berghuis, Bianca mailto [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands]
Campbell, Ellen mailto [Belfast Health and Social Care Trust, Belfast, United Kingdom]
Coppola, Antonietta mailto [University of Genoa, Genoa, Italy > Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health]
Francis, Ben mailto [University of Liverpool, Liverpool, United Kingdom > Department of Biostatistics]
Wolking, Stefan mailto [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
Cavalleri, Gianpiero L. mailto [Royal College of Surgeons in Ireland, Dublin, Ireland > Molecular and Cellular Therapeutics]
Craig, John mailto [Belfast Health and Social Care Trust, Belfast, United Kingdom]
Delanty, Norman mailto [Royal College of Surgeons in Ireland, Dublin, Ireland > Molecular and Cellular Therapeutics > > ; Beaumont Hospital, Dublin, Ireland > Department of Neurology]
Koeleman, Bobby P. C. mailto [University Medical Center Utrecht, Utrecht, Netherlands > Department of Genetics]
Kunz, Wolfram S. mailto [University of Bonn, Bonn, Germany > Department of Epileptology]
Lerche, Holger mailto [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
Marson, Anthony G. mailto [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology > > ; The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom]
Sander, Josemir W. mailto [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands > > > ; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, London, United Kingdom > > > ; The Chalfont Centre for Epilepsy, Chalfont St. Peters, United Kingdom]
Sills, Graeme J. mailto [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology]
Striano, Pasquale mailto [University of Genoa, Genoa, Italy > Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health]
Zara, Federico mailto [Laboratory of Neurogenetics and Neuroscience, Institute G. Gaslini, Genoa, Italy]
Sisodiya, Sanjay M. mailto [UCL Institute of Neurology, London, United Kingdom > Department of Clinical and Experimental Epilepsy > > ; The Chalfont Centre for Epilepsy, Chalfont St. Peters, United Kingdom]
Depondt, Chantal mailto [Université Libre de Bruxelles, Brussels, Belgium > Laboratory of Experimental Neurology > > ; Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium > Department of Neurology]
the EpiPGX Consortium []
* These authors have contributed equally to this work.
31-Aug-2017
Epilepsia
Blackwell Science
1-8
Yes (verified by ORBilu)
International
0013-9580
1528-1167
Malden
MA
[en] retention ; efficacy ; adverse drug reactions ; drug response ; seizure freedom
[en] Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a
common epilepsy syndrome that is often poorly controlled by antiepileptic drug
(AED) treatment. Comparative AED effectiveness studies in this condition are lacking.
Wereport retention, efficacy, and tolerability in a cohort of patients with MTLE-HS.
Methods: Clinical data were collected from a European database of patients with epilepsy.
We estimated retention, 12-month seizure freedom, and adverse drug reaction
(ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS.
Results: Seven hundred sixty-seven patients with a total of 3,249 AED trials were
included. The highest 12-month retention rates were observed with carbamazepine
(85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates
varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response
rates were highest for AEDs that were prescribed as initial treatment and lowest for
AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of
patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate
(30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin
(8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy
and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia.
Significance: Our results did not demonstrate any clear advantage of newer versus
older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR
rates in patients with MTLE-HS.
European Commission. Grant Number: 279062 ; Framework of the EU-funded FP7 research program BioCog ; Department of Health's NIHR Biomedical Research Centre's funding scheme ; Christelijke Vereniging voor de Verpleging van Lijders aan Epilepsie ; University of Liverpool ; Italian League Against Epilepsy (LICE) ; German Society for Epileptology ; Foundation no epilep ; Dr. Marvin Weil Epilepsy Research Fund ; Italian Ministry of Health ; European Community Sixth ; Telethon Foundation ; Italian League Against Epilepsy
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/32621
10.1111/epi.13871
http://onlinelibrary.wiley.com/doi/10.1111/epi.13871/full
FP7 ; 602461 - BIOCOG - Biomarker Development for Postoperative Cognitive Impairment in the Elderly

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