Reference : Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lob...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/32621

Title :	Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
Language :	English
Author, co-author :	Androsova, Ganna* [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Krause, Roland* [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Borghei, Mojgansadat [Université Libre de Bruxelles, Brussels, Belgium > Laboratory of Experimental Neurology]
	Wassenaar, Merel [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands]
	Auce, Pauls [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology > > ; The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom]
	Avbersek, Andreja [UCL Institute of Neurology, London, United Kingdom > Department of Clinical and Experimental Epilepsy]
	Becker, Felicitas [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
	Berghuis, Bianca [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands]
	Campbell, Ellen [Belfast Health and Social Care Trust, Belfast, United Kingdom]
	Coppola, Antonietta [University of Genoa, Genoa, Italy > Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health]
	Francis, Ben [University of Liverpool, Liverpool, United Kingdom > Department of Biostatistics]
	Wolking, Stefan [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
	Cavalleri, Gianpiero L. [Royal College of Surgeons in Ireland, Dublin, Ireland > Molecular and Cellular Therapeutics]
	Craig, John [Belfast Health and Social Care Trust, Belfast, United Kingdom]
	Delanty, Norman [Royal College of Surgeons in Ireland, Dublin, Ireland > Molecular and Cellular Therapeutics > > ; Beaumont Hospital, Dublin, Ireland > Department of Neurology]
	Koeleman, Bobby P. C. [University Medical Center Utrecht, Utrecht, Netherlands > Department of Genetics]
	Kunz, Wolfram S. [University of Bonn, Bonn, Germany > Department of Epileptology]
	Lerche, Holger [Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany]
	Marson, Anthony G. [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology > > ; The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom]
	Sander, Josemir W. [Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands > > > ; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, London, United Kingdom > > > ; The Chalfont Centre for Epilepsy, Chalfont St. Peters, United Kingdom]
	Sills, Graeme J. [Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom > Department of Molecular and Clinical Pharmacology]
	Striano, Pasquale [University of Genoa, Genoa, Italy > Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health]
	Zara, Federico [Laboratory of Neurogenetics and Neuroscience, Institute G. Gaslini, Genoa, Italy]
	Sisodiya, Sanjay M. [UCL Institute of Neurology, London, United Kingdom > Department of Clinical and Experimental Epilepsy > > ; The Chalfont Centre for Epilepsy, Chalfont St. Peters, United Kingdom]
	Depondt, Chantal [Université Libre de Bruxelles, Brussels, Belgium > Laboratory of Experimental Neurology > > ; Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium > Department of Neurology]
	the EpiPGX Consortium []
	* These authors have contributed equally to this work.
Publication date :	31-Aug-2017
Journal title :	Epilepsia
Publisher :	Blackwell Science
Pages :	1-8
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	0013-9580
e-ISSN :	1528-1167
City :	Malden
Country :	MA
Keywords :	[en] retention ; efficacy ; adverse drug reactions ; drug response ; seizure freedom
Abstract :	[en] Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. Wereport retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. Methods: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. Results: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. Significance: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS.
Funders :	European Commission. Grant Number: 279062 ; Framework of the EU-funded FP7 research program BioCog ; Department of Health's NIHR Biomedical Research Centre's funding scheme ; Christelijke Vereniging voor de Verpleging van Lijders aan Epilepsie ; University of Liverpool ; Italian League Against Epilepsy (LICE) ; German Society for Epileptology ; Foundation no epilep ; Dr. Marvin Weil Epilepsy Research Fund ; Italian Ministry of Health ; European Community Sixth ; Telethon Foundation ; Italian League Against Epilepsy
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/10993/32621
DOI :	10.1111/epi.13871
Other URL :	http://onlinelibrary.wiley.com/doi/10.1111/epi.13871/full
Framework Programme / European Project :	FP7 ; 602461 - BIOCOG - Biomarker Development for Postoperative Cognitive Impairment in the Elderly

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