Reference : Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lob... |
Scientific journals : Article | |||
Human health sciences : Multidisciplinary, general & others | |||
Systems Biomedicine | |||
http://hdl.handle.net/10993/32621 | |||
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis | |
English | |
Androsova, Ganna* ![]() | |
Krause, Roland* ![]() | |
Borghei, Mojgansadat ![]() | |
Wassenaar, Merel ![]() | |
Auce, Pauls ![]() | |
Avbersek, Andreja ![]() | |
Becker, Felicitas ![]() | |
Berghuis, Bianca ![]() | |
Campbell, Ellen ![]() | |
Coppola, Antonietta ![]() | |
Francis, Ben ![]() | |
Wolking, Stefan ![]() | |
Cavalleri, Gianpiero L. ![]() | |
Craig, John ![]() | |
Delanty, Norman ![]() | |
Koeleman, Bobby P. C. ![]() | |
Kunz, Wolfram S. ![]() | |
Lerche, Holger ![]() | |
Marson, Anthony G. ![]() | |
Sander, Josemir W. ![]() | |
Sills, Graeme J. ![]() | |
Striano, Pasquale ![]() | |
Zara, Federico ![]() | |
Sisodiya, Sanjay M. ![]() | |
Depondt, Chantal ![]() | |
the EpiPGX Consortium [] | |
* These authors have contributed equally to this work. | |
31-Aug-2017 | |
Epilepsia | |
Blackwell Science | |
1-8 | |
Yes (verified by ORBilu) | |
International | |
0013-9580 | |
1528-1167 | |
Malden | |
MA | |
[en] retention ; efficacy ; adverse drug reactions ; drug response ; seizure freedom | |
[en] Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a
common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. Wereport retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. Methods: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. Results: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. Significance: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS. | |
European Commission. Grant Number: 279062 ; Framework of the EU-funded FP7 research program BioCog ; Department of Health's NIHR Biomedical Research Centre's funding scheme ; Christelijke Vereniging voor de Verpleging van Lijders aan Epilepsie ; University of Liverpool ; Italian League Against Epilepsy (LICE) ; German Society for Epileptology ; Foundation no epilep ; Dr. Marvin Weil Epilepsy Research Fund ; Italian Ministry of Health ; European Community Sixth ; Telethon Foundation ; Italian League Against Epilepsy | |
Researchers ; Professionals ; Students ; General public | |
http://hdl.handle.net/10993/32621 | |
10.1111/epi.13871 | |
http://onlinelibrary.wiley.com/doi/10.1111/epi.13871/full | |
FP7 ; 602461 - BIOCOG - Biomarker Development for Postoperative Cognitive Impairment in the Elderly |
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