Reference : Molecular mechanisms of kinase inhibitor resistance in melanoma
Dissertations and theses : Doctoral thesis
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
Molecular mechanisms of kinase inhibitor resistance in melanoma
Cesi, Giulia mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
University of Luxembourg, ​​Luxembourg
Docteur en Biologie
Kreis, Stephanie mailto
Haan, Serge mailto
Janji, Bassam mailto
Kulms, Dagmar mailto
Thorsen, Frits mailto
[en] melanoma ; drug resistance ; kinase inhibitors ; extracellular vesicles ; microRNAs ; metabolism
[en] In my thesis, I elucidated several aspects of melanoma biology, all related to the influence of
targeted therapies in both responding and resistant melanoma cells. To better understand the MAPK signalling pathway, the impact of BRAF inhibitors on metabolic alterations as well as the connection between BRAF inhibitors and the onset of drug resistance was investigated. This introduction is focused on four topics: i) melanoma, ii) cancer metabolism, iii) miRNAs and iv) extracellular vesicles. First, melanoma biology including incidence rates, etiology, canonical and altered signalling pathways, therapies and resistance mechanisms will be introduced. The second part of the introduction will concentrate on metabolic alterations in the context of cancer and their implication on proliferation and survival. Thirdly, miRNAs and extracellular vesicles will be illustrated providing insights into their role in cancer development and especially drug resistance
University of Luxembourg - UL

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