Article (Scientific journals)
IL-24: Physiological and supraphysiological effects on normal and malignant cells
MARGUE, Christiane; KREIS, Stephanie
2010In Current Medicinal Chemistry, 17 (29), p. 3318-3326
Peer Reviewed verified by ORBi
 

Files


Full Text
Abstract_IL-24 physiological and supraphysiological effects on normal and malignant cells._SK_19.09.17.docx
Publisher postprint (14.94 kB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Adenovirus; Cancer; Cytokine; IL-24; Inflammation; Skin disease
Abstract :
[en] IL-24, previously known as melanoma differentiation antigen 7 (mda-7), is a member of the IL-10 family of cytokines and is mainly produced by Th 2 cells and activated monocytes. Binding of IL-24 to either of its two heterodimeric receptors IL-20R1/IL-20R2 and IL-22R/IL-20R2 triggers phosphorylation and consequently activation of STAT3 and/or STAT1 in target tissues such as lung, testis, ovary, keratinocytes and skin. There is accumulating evidence that skin represents a major target tissue for IL-24 and related cytokines such as IL-19, -20, and -22. To date, the physiological properties of IL-24 are incompletely understood but available data indicate that it affects epidermal functions by increasing proliferation of dermal cells, suggestive of a possible role in psoriasis. However, the initial interest in IL-24 did not arise from its physiological signaling properties through its cognate receptors but rather because this cytokine has been reported to efficiently kill cancer cells independent of receptor expression and Jak-STAT signaling. These potentially intriguing properties have led to the development of adenovirally expressed IL-24, which was reported to induce selective cancer cell death in many different malignancies by activation or deactivation of a continuously growing list of distinct signaling pathways without harming surrounding healthy cells. In the present review we critically revisit and discuss the potential of IL-24 to become a selective and cancer cell-specific oncolytic drug and put these tentative properties into context with recent data on the physiological properties of this cytokine. © 2010 Bentham Science Publishers Ltd.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
MARGUE, Christiane  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
KREIS, Stephanie ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
IL-24: Physiological and supraphysiological effects on normal and malignant cells
Publication date :
2010
Journal title :
Current Medicinal Chemistry
ISSN :
0929-8673
eISSN :
1875-533X
Publisher :
Bentham Science Publishers Ltd., Schiphol, Netherlands
Volume :
17
Issue :
29
Pages :
3318-3326
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Commentary :
cited By (since 1996)2 ingn 241, Introgen, United States Scopus
Available on ORBilu :
since 20 September 2017

Statistics


Number of views
104 (3 by Unilu)
Number of downloads
23 (2 by Unilu)

Scopus citations®
 
12
Scopus citations®
without self-citations
12
OpenCitations
 
11
WoS citations
 
10

Bibliography


Similar publications



Contact ORBilu