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Article (Scientific journals)
Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.
Langley, Gillian R.; Adcock, Ian M.; Busquet, Francois et al.
2017In Drug Discovery Today, 22 (2), p. 327-339
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Abstract :
[en] Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Langley, Gillian R.
Adcock, Ian M.
Busquet, Francois
Crofton, Kevin M.
Csernok, Elena
Giese, Christoph
Heinonen, Tuula
Herrmann, Kathrin
Hofmann-Apitius, Martin
Landesmann, Brigitte
Marshall, Lindsay J.
McIvor, Emily
Muotri, Alysson R.
Noor, Fozia ;  Saarland University > Biochemical Engineering
Schutte, Katrin
Seidle, Troy
van de Stolpe, Anja
Van Esch, Hilde
Willett, Catherine
Woszczek, Grzegorz
More authors (10 more) Less
External co-authors :
yes
Language :
English
Title :
Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.
Publication date :
2017
Journal title :
Drug Discovery Today
ISSN :
1359-6446
Publisher :
Elsevier, Netherlands
Volume :
22
Issue :
2
Pages :
327-339
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016 Elsevier Ltd. All rights reserved.
Available on ORBilu :
since 13 September 2017

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