Article (Scientific journals)
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults
Hootman, Katie C.; Trezzi, Jean-Pierre; Kraemer, Lisa et al.
2017In Proceedings of the National Academy of Sciences of the United States of America
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Keywords :
erythritol; metabolomics; pentose-phosphate pathway; adiposity; weight gain
Abstract :
[en] Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by phenotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (HbA1c) > 5.05%, HbA1c < 4.92%] and assayed using GC-MS, chromatograms were analyzed using MetaboliteDetector software, and normalized metabolite levels were compared using Welch’s t test. Assays were repeated using freshly prepared pools, and statistically significant metabolites were quantified in a targeted GC-MS approach. Isotope tracer studies were performed to determine if the potential marker was an endogenous human metabolite in men and in whole blood. Participants with incident central adiposity gain had statistically significantly higher blood erythritol [P < 0.001, false discovery rate (FDR) = 0.0435], and the targeted assay revealed 15-fold [95% confidence interval (CI): 13.27, 16.25] higher blood erythritol compared with participants with stable adiposity. Participants with baseline HbA1c > 5.05% had 21-fold (95% CI: 19.84, 21.41) higher blood erythritol compared with participants with lower HbA1c (P < 0.001, FDR = 0.00016). Erythritol was shown to be synthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assisted ex vivo blood incubation experiments and through in vivo conversion of erythritol to erythronate in stable isotope-assisted dried blood spot experiments. Therefore, endogenous production of erythritol from glucose may contribute to the association between erythritol and obesity observed in young adults.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hootman, Katie C. ;  Cornell University > Division of Nutritional Sciences
Trezzi, Jean-Pierre  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kraemer, Lisa ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Burwell, Lindsay S.;  Cornell University > Division of Nutritional Sciences
Dong, Xiangyi  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Guertin, Kristin A.;  Cornell University > Division of Nutritional Sciences
Jäger, Christian  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Stover, Patrick J.;  Cornell University > Division of Nutritional Sciences
Hiller, Karsten ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Cassano, Patricia A.;  Cornell University > Division of Nutritional Sciences
 These authors have contributed equally to this work.
External co-authors :
yes
Language :
English
Title :
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults
Publication date :
08 May 2017
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Cornell University
NIH Institutional Research Training Grant T32-DK-7158-38
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 15 May 2017

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