Reference : Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity ga...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/31106
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults
English
Hootman, Katie C.* mailto [Cornell University > Division of Nutritional Sciences]
Trezzi, Jean-Pierre* mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Kraemer, Lisa mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Burwell, Lindsay S. mailto [Cornell University > Division of Nutritional Sciences]
Dong, Xiangyi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Guertin, Kristin A. mailto [Cornell University > Division of Nutritional Sciences]
Jäger, Christian mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Stover, Patrick J. mailto [Cornell University > Division of Nutritional Sciences]
Hiller, Karsten mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Cassano, Patricia A. mailto [Cornell University > Division of Nutritional Sciences]
* These authors have contributed equally to this work.
8-May-2017
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
Yes (verified by ORBilu)
International
0027-8424
1091-6490
Washington
DC
[en] erythritol ; metabolomics ; pentose-phosphate pathway ; adiposity ; weight gain
[en] Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by phenotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (HbA1c) > 5.05%, HbA1c < 4.92%] and assayed using GC-MS, chromatograms were analyzed using MetaboliteDetector software, and normalized metabolite levels were compared using Welch’s t test. Assays were repeated using freshly prepared pools, and statistically significant metabolites were quantified in a targeted GC-MS approach. Isotope tracer studies were performed to determine if the potential marker was an endogenous human metabolite in men and in whole blood. Participants with incident central adiposity gain had statistically significantly higher blood erythritol [P < 0.001, false discovery rate (FDR) = 0.0435], and the targeted assay revealed 15-fold [95% confidence interval (CI): 13.27, 16.25] higher blood erythritol compared with participants with stable adiposity. Participants with baseline HbA1c > 5.05% had 21-fold (95% CI: 19.84, 21.41) higher blood erythritol compared with participants with lower HbA1c (P < 0.001, FDR = 0.00016). Erythritol was shown to be synthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assisted ex vivo blood incubation experiments and through in vivo conversion of erythritol to erythronate in stable isotope-assisted dried blood spot experiments. Therefore, endogenous production of erythritol from glucose may contribute to the association between erythritol and obesity observed in young adults.
Luxembourg Centre for Systems Biomedicine (LCSB)
Cornell University ; NIH Institutional Research Training Grant T32-DK-7158-38 ; Fonds National de la Recherche - FnR
Researchers ; Students
http://hdl.handle.net/10993/31106
10.1073/pnas.1620079114
http://www.pnas.org/content/early/2017/05/02/1620079114

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