  | ZHANG, J., Keibler, M. A., Dong, W., GHELFI, J., Cordes, T., Kanashova, T., Pailot, A., LINSTER, C., DITTMAR, G., Metallo, C. M., Lautenschlaeger, T., HILLER, K., & Stephanopoulos, G. (19 October 2023). Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines, 11 (10), 2842. doi:10.3390/biomedicines11102842  Peer Reviewed verified by ORBi |
  | TREZZI, J.-P., Galozzi, S., Jäger, C., Barkovits, K., Brockmann, K., Maetzler, W., Berg, D., Marcus, K., Betsou, F., HILLER, K., & Mollenhauer, B. (2017). Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease: Early Parkinson'S CSF Metabolic Signature. Movement Disorders. doi:10.1002/mds.27132 Peer reviewed |
 | Hootman, K. C.* , TREZZI, J.-P.* , KRAEMER, L., Burwell, L. S., DONG, X., Guertin, K. A., Jäger, C., Stover, P. J., HILLER, K., & Cassano, P. A. (2017). Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1620079114 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., Jäger, C., Chen, Y., Pinkenburg, O., Camara, B., Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., ... Brenner, D. (18 April 2017). Glutathione Primes T Cell Metabolism for Inflammation. Immunity, 46 (4), 675-689. doi:10.1016/j.immuni.2017.03.019 Peer reviewed |
 | Nonnenmacher, Y., Palorini, R., FOUQUIER D'HÉROUËL, A., Krämer, L., Neumann-Schaal, M., Chiaradonna, F., SKUPIN, A., Wegner, A., & HILLER, K. (2017). Analysis of mitochondrial metabolism in situ: Combining stable isotope labeling with selective permeabilization. Metabolic Engineering. doi:10.1016/j.ymben.2016.12.005 Peer reviewed |
 | Doppler, M., Kluger, B., Bueschl, C., Schneider, C., Krska, R., DELCAMBRE, S., HILLER, K., Lemmens, M., & Schuhmacher, R. (2016). Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. International Journal of Molecular Sciences. doi:10.3390/IJMS17071017 Peer reviewed |
 | TREZZI, J.-P., Bulla, A., Bellora, C., Rose, M., Lescuyer, P., Kiehntopf, M., HILLER, K., & Betsou, F. (June 2016). LacaScore: a novel plasma sample quality control tool based on ascorbic acid and lactic acid levels. Metabolomics : Official journal of the Metabolomic Society, 12 (96). doi:10.1007/s11306-016-1038-1 Peer reviewed |
 | Zhang, H., Badur, M. G., Divakaruni, A. S., Parker, S. J., Jäger, C., HILLER, K., Murphy, A. N., & Metallo, C. M. (2016). Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Reports, 16 (6), 1536--1547. doi:10.1016/j.celrep.2016.06.102 Peer Reviewed verified by ORBi |
Jäger, C., HILLER, K., & BUTTINI, M. (2016). Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry: Metabolic Profiling of Neurotransmitters by GC-MS. In J. Auwerx, S. L. Ackerman, S. D. Brown, M. J. Justice, ... J. Nadeau (Eds.), Current Protocols in Mouse Biology (pp. 333--342). Hoboken, NJ, USA, Unknown/unspecified: John Wiley Sons, Inc. doi:10.1002/cpmo.15 Peer reviewed |
 | SAPCARIU, S., Kanashova, T., Dilger, M., Diabate, S., Oeder, S., Passig, J., Radischat, C., Buters, J., Sippula, O., Streibel, T., Paur, H.-R., Schlager, C., Mulhopt, S., Stengel, B., Rabe, R., Harndorf, H., Krebs, T., Karg, E., Groger, T., ... Zimmermann, R. (2016). Metabolic Profiling as Well as Stable Isotope Assisted Metabolic and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel. PLoS ONE, 11 (6), 0157964. doi:10.1371/journal.pone.0157964 Peer Reviewed verified by ORBi |
 | Lorendeau, D., Rinaldi, G., Boon, R., Spincemaille, P., Metzger, K., Jäger, C., Christen, S., DONG, X., Kuenen, S., Voordeckers, K., Verstreken, P., Cassiman, D., Vermeersch, P., Verfaillie, C., HILLER, K., & Fendt, S.-M. (2016). Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Metabolic Engineering. doi:10.1016/j.ymben.2016.11.005 Peer reviewed |
 | Palorini, R., Votta, G., Pirola, Y., De Vitto, H., De Palma, S., Airoldi, C., Vasso, M., Ricciardiello, F., Lombardi, P. P., Cirulli, C., Rizzi, R., Nicotra, F., HILLER, K., Gelfi, C., Alberghina, L., & Chiaradonna, F. (2016). Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis. PLoS Genetics, 12 (3), 1005931. doi:10.1371/journal.pgen.1005931 Peer Reviewed verified by ORBi |
 | BATTELLO, N., ZIMMER, A. D., Goebel, C., DONG, X., BEHRMANN, I., HAAN, C., HILLER, K., & Wegner, A. (2016). The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells. Cancer and Metabolism, 4, 3. doi:10.1186/s40170-016-0141-0 Peer Reviewed verified by ORBi |
 | MEISER, J., DELCAMBRE, S., WEGNER, A., Jäger, C., GHELFI, J., FOUQUIER D'HÉROUËL, A., DONG, X., WEINDL, D., Stautner, C., NONNENMACHER, Y., MICHELUCCI, A., Popp, O., Giesert, F., Schildknecht, S., KRAEMER, L., Schneider, J. G., Woitalla, D., Wurst, W., SKUPIN, A., ... HILLER, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019 Peer Reviewed verified by ORBi |
 | SAPCARIU, S., Oeder, S., Kanashova, T., Sippula, O., Streibel, T., Arteaga-Salas, J. M., Passig, J., Dilger, M., Paur, H.-R., Schlager, C., Mülhopt, S., Diabaté, S., Weiss, C., Stengel, B., Rabe, R., Harnsdorf, H., Torvela, T., Jokiniemi, J., Hirvonen, M.-R., ... Zimmermann, R. (2015). Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions. PLoS ONE. doi:10.1371/journal.pone.0126536 Peer Reviewed verified by ORBi |
 | WEINDL, D., WEGNER, A., Jäger, C., & HILLER, K. (10 April 2015). Isotopologue ratio normalization for non-targeted metabolomics. Journal of Chromatography. A, 1389, 112–119. doi:10.1016/j.chroma.2015.02.025 Peer Reviewed verified by ORBi |
 | WEGNER, A., MEISER, J., WEINDL, D., & HILLER, K. (2015). How metabolites modulate metabolic flux. Current Opinion in Biotechnology, 34, 16-22. doi:10.1016/j.copbio.2014.11.008 Peer Reviewed verified by ORBi |
 | WEINDL, D., WEGNER, A., & HILLER, K. (2015). Metabolome-wide analysis of stable isotope labeling - Is it worth the effort? Frontiers in Physiology, 6 (344). doi:10.3389/fphys.2015.00344 Peer Reviewed verified by ORBi |
 | WEINDL, D., WEGNER, A., & HILLER, K. (2015). Non-targeted tracer fate detection. Methods in Enzymology, 561, 227-302. doi:10.1016/bs.mie.2015.04.003 Peer Reviewed verified by ORBi |
 | Schildknecht, S., Pape, R., Meiser, J., Karreman, C., Strittmatter, T., Odermatt, M., Cirri, E., Friemel, A., Ringwald, M., Pasquarelli, N., Ferger, B., Brunner, T., Marx, A., Möller, H., HILLER, K., & Leist, M. (2015). Preferential extracellular generation of the active parkinsonian toxin MPP+ by transporter-independent export of the intermediate MPDP+. Antioxidants & redox signaling. doi:10.1089/ars.2015.6297 Peer reviewed |
 | Meiser, J., KRAEMER, L., SAPCARIU, S., BATTELLO, N., GHELFI, J., FOUQUIER D'HÉROUËL, A., SKUPIN, A., & HILLER, K. (2015). Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. Journal of Biological Chemistry. doi:10.1074/jbc.M115.676817 Peer reviewed |
 | Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., Gottlieb, E., HILLER, K., Jones, R. G., Kamphorst, J. J., Kibbey, R. G., Kimmelman, A. C., Locasale, J. W., Lunt, S. Y., Maddocks, O. D. K., ... Fendt, S.-M. (2015). A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, 189-201. doi:10.1016/j.copbio.2015.02.003 Peer Reviewed verified by ORBi |
 | Cordes, T., MICHELUCCI, A., & HILLER, K. (2015). Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite. Annual review of nutrition. doi:10.1146/annurev-nutr-071714-034243 Peer reviewed |
 | Missios, P., Zhou, Y., Guachalla, L. M., von Figura, G., WEGNER, A., Chakkarappan, S. R., Binz, T., Gompf, A., Hartleben, G., Lellek, V., Wang Sattler, R., Song, Z., Illig, T., Klaus, S., Böhm, B., Wenz, T., HILLER, K., & Rudolph, K. L. (2014). Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice. Nature Communications. doi:10.1038/ncomms5924 Peer Reviewed verified by ORBi |
 | Choi, C., Münch, R., Klein, J., Siegel, I., Thielen, B., Benkert, B., Kucklick, M., Schobert, M., Barthelmes, J., Ebeling, C., Haddad, I., Scheer, M., Grote, A., HILLER, K., Boyke, B., Schreiber, K., & Retter, I. (2014). NAR Molecular Biology Database Collection entry number 0953. Nucleic Acids Research. Peer Reviewed verified by ORBi |
 | WEGNER, A., WEINDL, D., Jäger, C., SAPCARIU, S., DONG, X., Stephanopoulos, G., & HILLER, K. (January 2014). Fragment Formula Calculator (FFC): Determination of chemical formulas for fragment ions in mass spectrometric data. Analytical Chemistry, 86 (4), 2221–2228. doi:10.1021/ac403879d Peer Reviewed verified by ORBi |
 | SAPCARIU, S., Kanashova, T., WEINDL, D., GHELFI, J., Dittmar, G., & HILLER, K. (2014). Simultaneous extraction of proteins and metabolites from cells in culture. MethodsX. doi:10.1016/j.mex.2014.07.002 Peer Reviewed verified by ORBi |
 | Ammerlaan, W., TREZZI, J.-P., Mathay, C., HILLER, K., & Betsou, F. (2014). Method validation for preparing urine samples for downstream proteomic and metabolomic applications. Biopreservation and Biobanking, 12 (5), 351-7. doi:10.1089/bio.2014.0013 Peer Reviewed verified by ORBi |
 | Ammerlaan, W., TREZZI, J.-P., Lescuyer, P., Mathay,, C., HILLER, K., & Betsou, F. (2014). Method Validation for Preparing Serum and Plasma Samples from Human Blood for Downstream Proteomic, Metabolomic, and Circulating Nucleic Acid-Based Applications. Biopreservation and biobanking. doi:10.1089/bio.2014.0003 Peer reviewed |
HEINTZ, A., MAY, P., LEBRUN, L., Ferrand, J., TREZZI, J.-P., Collignon, S., WAMPACH, L., GLAAB, E., LACZNY, C. C., MARTINS CONDE, P., KAYSEN, A., SCHNEIDER, J., HILLER, K., Hogan, A., WILMES, P., & DE BEAUFORT, C. (October 2013). Meta-omic Analyses of the Microbiome in a Family Study of Diabetes Mellitus [Poster presentation]. 2nd International Systems Biomedicine Symposium, Belval, Luxembourg. |
 | MICHELUCCI, A., CORDES, T., GHELFI, J., PAILOT, A., Reiling, N., Goldmann, O., Binz, T., WEGNER, A., TALLAM, A., Rausell, A., BUTTINI, M., LINSTER, C., Medina, E., BALLING, R., & HILLER, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 Peer Reviewed verified by ORBi |
 | WEGNER, A., SAPCARIU, S., WEINDL, D., & HILLER, K. (28 March 2013). Isotope Cluster-Based Compound Matching in Gas Chromatography/ Mass Spectrometry for Non-Targeted Metabolomics. Analytical Chemistry, 85 (8), 4030-4037. doi:10.1021/ac303774z Peer Reviewed verified by ORBi |
 | HILLER, K., WEGNER, A., WEINDL, D., CORDES, T., Metallo, C. M., Kelleher, J. K., & Stephanopoulos, G. (11 March 2013). NTFD - A stand-alone application for the non-targeted detection of stable isotope labeled compounds in GC/MS data. Bioinformatics, 29 (9), 1226-8. doi:10.1093/bioinformatics/btt119 Peer reviewed |
 | MEISER, J., WEINDL, D., & HILLER, K. (2013). Complexity of dopamine metabolism. Cell Communication and Signaling, 11 (34). doi:10.1186/1478-811X-11-34 Peer Reviewed verified by ORBi |
 | HILLER, K., & Metallo, C. M. (2013). Profiling metabolic networks to study cancer metabolism. Current Opinion in Biotechnology. doi:10.1016/j.copbio.2012.11.001 Peer Reviewed verified by ORBi |
 | Müller, S., & HILLER, K. (2013). From multi-omics to basic structures of biological systems. Current Opinion in Biotechnology, 24, 1-3. doi:10.1016/j.copbio.2012.12.002 Peer Reviewed verified by ORBi |
 | HILLER, K. (2013). Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death and Differentiation. Peer reviewed |
 | Krug, A., Gutbier, S., Zhao, L., Kullmann, C., Ivanova, V., Förster, S., Jagtap, S., MEISER, J., Leparc, G., Schildknecht, S., Adam, M., HILLER, K., Farhan, H., Brunner, T., Hartung, T., Sachinidis, A., & Leist, M. (2013). Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death and Disease. doi:10.1038/cddis.2014.166 Peer Reviewed verified by ORBi |
 | McGuirk, S., Gravel, S.-P., Deblois, G., Papadopoli, D., Faubert, B., WEGNER, A., HILLER, K., Avizonis, D., Akavia, U. D., Jones, R. G., Giguère, V., & St-Pierre, J. (2013). PGC-1α supports glutamine metabolism in breast cancer. Cancer and Metabolism. Peer Reviewed verified by ORBi |
 | ROUME, H., MULLER, E., CORDES, T., Renaut, J., HILLER, K., & WILMES, P. (2013). A biomolecular isolation framework for eco-systems biology. ISME Journal, 7 (1), 110-121. doi:10.1038/ismej.2012.72 Peer Reviewed verified by ORBi |
 | HILLER, K. (2012). Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. doi:10.1038/nature10602 Peer Reviewed verified by ORBi |
ROUME, H., MULLER, E., CORDES, T., HILLER, K., & WILMES, P. (2012). A biomolecular isolation framework for eco-systems biology [Poster presentation]. 14th International Symposium on Microbial Ecology. |
 | WEGNER, A., CORDES, T., MICHELUCCI, A., & HILLER, K. (2012). The Application of Stable Isotope Assisted Metabolomics in Biomedicine. Current Biotechnology, 1, 88-97. Peer Reviewed verified by ORBi |
ROUME, H., MULLER, E., CORDES, T., HILLER, K., & WILMES, P. (2011). Isolation of biomolecules from a single sample: the first step towards integrated omic analyses [Poster presentation]. 1st International Systems Biomedicine Symposium. |
 | HILLER, K. (2011). Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Molecular Systems Biology. doi:10.1038/msb.2011.56 Peer Reviewed verified by ORBi |
 | HILLER, K., Metallo, C. M., Kelleher, J. K., & Stephanopoulos, G. (2010). Nontargeted Elucidation of Metabolic Pathways Using Stable-Isotope Tracers and Mass Spectrometry. Analytical Chemistry. doi:10.1021/ac1011574 Peer Reviewed verified by ORBi |
| Haddad, I., HILLER, K., Frimmersdorf, E., Benkert, B., Schomburg, D., & Jahn, D. (2009). An emergent self-organizing map based analysis pipeline for comparative metabolome studies. In Silico Biology. doi:10.3233/ISB-2009-0396 Peer reviewed |
 | HILLER, K., Hangebrauk, J., Jäger, C., Spura, J., Schreiber, K., & Schomburg, D. (2009). MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis. Analytical Chemistry. doi:10.1021/ac802689c Peer Reviewed verified by ORBi |
| Choi, C., Münch, R., Leupold, S., Klein, J., Siegel, I., Thielen, B., Benkert, B., Kucklick, M., Schobert, M., Barthelmes, J., Ebeling, C., Haddad, Scheer, M., Grote, A., HILLER, K., Bunk, B., Schreiber, Retter, I., Schomburg, D., & Jahn, D. (2007). SYSTOMONAS — an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Research. doi:10.1093/nar/gkl823 Peer Reviewed verified by ORBi |
| HILLER, K., Schobert, M., Hundertmark, C., Jahn, D., & Münch, R. (2006). JVirGel 2.0: computational prediction of proteomes separated via two-dimensional gel electrophoresis under consideration of membrane and secreted proteins. Current Pharmaceutical Biotechnology. Peer Reviewed verified by ORBi |
| Scheer, M., Klawonn, F., Münch, R., Grote, A., HILLER, K., Choi, C., Koch, I., Schobert, M., Härtig, E., Klages, U., & Jahn, D. (2006). JProGO: a novel tool for the functional interpretation of prokaryotic microarray data using Gene Ontology information. Nucleic Acids Research. doi:10.1093/nar/gkl329 Peer Reviewed verified by ORBi |
| Bunk, B., Kucklick, M., Münch, R., Schobert, M., Jahn, D., & HILLER, K. (2006). MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data. Bioinformatics. doi:10.1093/bioinformatics/btl526 Peer reviewed |
| Münch, R., HILLER, K., Grote, A., Scheer, M., Klein, J., Schobert, M., & Jahn, D. (2005). Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes. Bioinformatics. doi:10.1093/bioinformatics/bti635 Peer reviewed |
| HILLER, K., Grote, A., Scheer, M., Münch, R., & Jahn, D. (2004). PrediSi: prediction of signal peptides and their cleavage positions. Nucleic Acids Research. doi:10.1093/nar/gkh378 Peer Reviewed verified by ORBi |
| HILLER, K., Schobert, M., Hundertmark, C., Jahn, D., & Münch, R. (2003). JVirGel: calculation of virtual two-dimensional protein gels. Nucleic Acids Research. doi:10.1093/nar/gkg536 Peer Reviewed verified by ORBi |
| Münch, R., HILLER, K., Barg, H., Heldt, D., Linz, S., Wingender, E., & Jahn, D. (2003). PRODORIC: prokaryotic database of gene regulation. Nucleic Acids Research. doi:10.1093/nar/gkg037 Peer Reviewed verified by ORBi |