![]() ![]() | ZHANG, J., Keibler, M. A., Dong, W., GHELFI, J., Cordes, T., Kanashova, T., Pailot, A., LINSTER, C., DITTMAR, G., Metallo, C. M., Lautenschlaeger, T., HILLER, K., & Stephanopoulos, G. (19 October 2023). Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines, 11 (10), 2842. doi:10.3390/biomedicines11102842 ![]() |
![]() ![]() | TREZZI, J.-P., Galozzi, S., Jäger, C., Barkovits, K., Brockmann, K., Maetzler, W., Berg, D., Marcus, K., Betsou, F., HILLER, K., & Mollenhauer, B. (2017). Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease: Early Parkinson'S CSF Metabolic Signature. Movement Disorders. doi:10.1002/mds.27132 ![]() |
![]() ![]() | Hootman, K. C.* , TREZZI, J.-P.* , KRAEMER, L., Burwell, L. S., DONG, X., Guertin, K. A., Jäger, C., Stover, P. J., HILLER, K., & Cassano, P. A. (2017). Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1620079114 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., Jäger, C., Chen, Y., Pinkenburg, O., Camara, B., Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., ... Brenner, D. (18 April 2017). Glutathione Primes T Cell Metabolism for Inflammation. Immunity, 46 (4), 675-689. doi:10.1016/j.immuni.2017.03.019 ![]() |
![]() ![]() | Nonnenmacher, Y., Palorini, R., FOUQUIER DU0027HÉROUËL, A., Krämer, L., Neumann-Schaal, M., Chiaradonna, F., SKUPIN, A., Wegner, A., & HILLER, K. (2017). Analysis of mitochondrial metabolism in situ: Combining stable isotope labeling with selective permeabilization. Metabolic Engineering. doi:10.1016/j.ymben.2016.12.005 ![]() |
![]() ![]() | Doppler, M., Kluger, B., Bueschl, C., Schneider, C., Krska, R., DELCAMBRE, S., HILLER, K., Lemmens, M., & Schuhmacher, R. (2016). Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. International Journal of Molecular Sciences. doi:10.3390/IJMS17071017 ![]() |
![]() ![]() | TREZZI, J.-P., Bulla, A., Bellora, C., Rose, M., Lescuyer, P., Kiehntopf, M., HILLER, K., & Betsou, F. (June 2016). LacaScore: a novel plasma sample quality control tool based on ascorbic acid and lactic acid levels. Metabolomics : Official journal of the Metabolomic Society, 12 (96). doi:10.1007/s11306-016-1038-1 ![]() |
![]() ![]() | SAPCARIU, S., Kanashova, T., Dilger, M., Diabate, S., Oeder, S., Passig, J., Radischat, C., Buters, J., Sippula, O., Streibel, T., Paur, H.-R., Schlager, C., Mulhopt, S., Stengel, B., Rabe, R., Harndorf, H., Krebs, T., Karg, E., Groger, T., ... Zimmermann, R. (2016). Metabolic Profiling as Well as Stable Isotope Assisted Metabolic and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel. PLoS ONE, 11 (6), 0157964. doi:10.1371/journal.pone.0157964 ![]() |
Jäger, C., HILLER, K., & BUTTINI, M. (2016). Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry: Metabolic Profiling of Neurotransmitters by GC-MS. In J. Auwerx, S. L. Ackerman, S. D. Brown, M. J. Justice, ... J. Nadeau (Eds.), Current Protocols in Mouse Biology (pp. 333--342). Hoboken, NJ, USA, Unknown/unspecified: John Wiley Sons, Inc. doi:10.1002/cpmo.15 ![]() |
![]() ![]() | Zhang, H., Badur, M. G., Divakaruni, A. S., Parker, S. J., Jäger, C., HILLER, K., Murphy, A. N., & Metallo, C. M. (2016). Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell Reports, 16 (6), 1536--1547. doi:10.1016/j.celrep.2016.06.102 ![]() |
![]() ![]() | Lorendeau, D., Rinaldi, G., Boon, R., Spincemaille, P., Metzger, K., Jäger, C., Christen, S., DONG, X., Kuenen, S., Voordeckers, K., Verstreken, P., Cassiman, D., Vermeersch, P., Verfaillie, C., HILLER, K., & Fendt, S.-M. (2016). Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Metabolic Engineering. doi:10.1016/j.ymben.2016.11.005 ![]() |
![]() ![]() | Palorini, R., Votta, G., Pirola, Y., De Vitto, H., De Palma, S., Airoldi, C., Vasso, M., Ricciardiello, F., Lombardi, P. P., Cirulli, C., Rizzi, R., Nicotra, F., HILLER, K., Gelfi, C., Alberghina, L., & Chiaradonna, F. (2016). Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis. PLoS Genetics, 12 (3), 1005931. doi:10.1371/journal.pgen.1005931 ![]() |
![]() ![]() | MEISER, J., DELCAMBRE, S., WEGNER, A., Jäger, C., GHELFI, J., FOUQUIER DU0027HÉROUËL, A., DONG, X., WEINDL, D., Stautner, C., NONNENMACHER, Y., MICHELUCCI, A., Popp, O., Giesert, F., Schildknecht, S., KRAEMER, L., Schneider, J. G., Woitalla, D., Wurst, W., SKUPIN, A., ... HILLER, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019 ![]() |
![]() ![]() | BATTELLO, N., ZIMMER, A. D., Goebel, C., DONG, X., BEHRMANN, I., HAAN, C., HILLER, K., & Wegner, A. (2016). The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells. Cancer and Metabolism, 4, 3. doi:10.1186/s40170-016-0141-0 ![]() |
![]() ![]() | SAPCARIU, S., Oeder, S., Kanashova, T., Sippula, O., Streibel, T., Arteaga-Salas, J. M., Passig, J., Dilger, M., Paur, H.-R., Schlager, C., Mülhopt, S., Diabaté, S., Weiss, C., Stengel, B., Rabe, R., Harnsdorf, H., Torvela, T., Jokiniemi, J., Hirvonen, M.-R., ... Zimmermann, R. (2015). Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions. PLoS ONE. doi:10.1371/journal.pone.0126536 ![]() |
![]() ![]() | WEINDL, D., WEGNER, A., Jäger, C., & HILLER, K. (10 April 2015). Isotopologue ratio normalization for non-targeted metabolomics. Journal of Chromatography. A, 1389, 112–119. doi:10.1016/j.chroma.2015.02.025 ![]() |
![]() ![]() | WEGNER, A., MEISER, J., WEINDL, D., & HILLER, K. (2015). How metabolites modulate metabolic flux. Current Opinion in Biotechnology, 34, 16-22. doi:10.1016/j.copbio.2014.11.008 ![]() |
![]() ![]() | WEINDL, D., WEGNER, A., & HILLER, K. (2015). Metabolome-wide analysis of stable isotope labeling - Is it worth the effort? Frontiers in Physiology, 6 (344). doi:10.3389/fphys.2015.00344 ![]() |
![]() ![]() | Schildknecht, S., Pape, R., Meiser, J., Karreman, C., Strittmatter, T., Odermatt, M., Cirri, E., Friemel, A., Ringwald, M., Pasquarelli, N., Ferger, B., Brunner, T., Marx, A., Möller, H., HILLER, K., & Leist, M. (2015). Preferential extracellular generation of the active parkinsonian toxin MPP+ by transporter-independent export of the intermediate MPDP+. Antioxidants & redox signaling. doi:10.1089/ars.2015.6297 ![]() |
![]() ![]() | WEINDL, D., WEGNER, A., & HILLER, K. (2015). Non-targeted tracer fate detection. Methods in Enzymology, 561, 227-302. doi:10.1016/bs.mie.2015.04.003 ![]() |
![]() ![]() | Cordes, T., MICHELUCCI, A., & HILLER, K. (2015). Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite. Annual review of nutrition. doi:10.1146/annurev-nutr-071714-034243 ![]() |
![]() ![]() | Meiser, J., KRAEMER, L., SAPCARIU, S., BATTELLO, N., GHELFI, J., FOUQUIER DU0027HÉROUËL, A., SKUPIN, A., & HILLER, K. (2015). Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. Journal of Biological Chemistry. doi:10.1074/jbc.M115.676817 ![]() |
![]() ![]() | Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., Gottlieb, E., HILLER, K., Jones, R. G., Kamphorst, J. J., Kibbey, R. G., Kimmelman, A. C., Locasale, J. W., Lunt, S. Y., Maddocks, O. D. K., ... Fendt, S.-M. (2015). A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, 189-201. doi:10.1016/j.copbio.2015.02.003 ![]() |
![]() ![]() | Missios, P., Zhou, Y., Guachalla, L. M., von Figura, G., WEGNER, A., Chakkarappan, S. R., Binz, T., Gompf, A., Hartleben, G., Lellek, V., Wang Sattler, R., Song, Z., Illig, T., Klaus, S., Böhm, B., Wenz, T., HILLER, K., & Rudolph, K. L. (2014). Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice. Nature Communications. doi:10.1038/ncomms5924 ![]() |
![]() ![]() | Choi, C., Münch, R., Klein, J., Siegel, I., Thielen, B., Benkert, B., Kucklick, M., Schobert, M., Barthelmes, J., Ebeling, C., Haddad, I., Scheer, M., Grote, A., HILLER, K., Boyke, B., Schreiber, K., & Retter, I. (2014). NAR Molecular Biology Database Collection entry number 0953. Nucleic Acids Research. ![]() |
![]() ![]() | Ammerlaan, W., TREZZI, J.-P., Mathay, C., HILLER, K., & Betsou, F. (2014). Method validation for preparing urine samples for downstream proteomic and metabolomic applications. Biopreservation and Biobanking, 12 (5), 351-7. doi:10.1089/bio.2014.0013 ![]() |
![]() ![]() | Ammerlaan, W., TREZZI, J.-P., Lescuyer, P., Mathay,, C., HILLER, K., & Betsou, F. (2014). Method Validation for Preparing Serum and Plasma Samples from Human Blood for Downstream Proteomic, Metabolomic, and Circulating Nucleic Acid-Based Applications. Biopreservation and biobanking. doi:10.1089/bio.2014.0003 ![]() |
![]() ![]() | SAPCARIU, S., Kanashova, T., WEINDL, D., GHELFI, J., Dittmar, G., & HILLER, K. (2014). Simultaneous extraction of proteins and metabolites from cells in culture. MethodsX. doi:10.1016/j.mex.2014.07.002 ![]() |
![]() ![]() | WEGNER, A., WEINDL, D., Jäger, C., SAPCARIU, S., DONG, X., Stephanopoulos, G., & HILLER, K. (January 2014). Fragment Formula Calculator (FFC): Determination of chemical formulas for fragment ions in mass spectrometric data. Analytical Chemistry, 86 (4), 2221–2228. doi:10.1021/ac403879d ![]() |
HEINTZ, A., MAY, P., LEBRUN, L., Ferrand, J., TREZZI, J.-P., Collignon, S., WAMPACH, L., GLAAB, E., LACZNY, C. C., MARTINS CONDE, P., KAYSEN, A., SCHNEIDER, J., HILLER, K., Hogan, A., WILMES, P., & DE BEAUFORT, C. (October 2013). Meta-omic Analyses of the Microbiome in a Family Study of Diabetes Mellitus [Poster presentation]. 2nd International Systems Biomedicine Symposium, Belval, Luxembourg. |
![]() ![]() | MICHELUCCI, A., CORDES, T., GHELFI, J., PAILOT, A., Reiling, N., Goldmann, O., Binz, T., WEGNER, A., TALLAM, A., Rausell, A., BUTTINI, M., LINSTER, C., Medina, E., BALLING, R., & HILLER, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 ![]() |
![]() ![]() | WEGNER, A., SAPCARIU, S., WEINDL, D., & HILLER, K. (28 March 2013). Isotope Cluster-Based Compound Matching in Gas Chromatography/ Mass Spectrometry for Non-Targeted Metabolomics. Analytical Chemistry, 85 (8), 4030-4037. doi:10.1021/ac303774z ![]() |
![]() ![]() | HILLER, K., WEGNER, A., WEINDL, D., CORDES, T., Metallo, C. M., Kelleher, J. K., & Stephanopoulos, G. (11 March 2013). NTFD - A stand-alone application for the non-targeted detection of stable isotope labeled compounds in GC/MS data. Bioinformatics, 29 (9), 1226-8. doi:10.1093/bioinformatics/btt119 ![]() |
![]() ![]() | MEISER, J., WEINDL, D., & HILLER, K. (2013). Complexity of dopamine metabolism. Cell Communication and Signaling, 11 (34). doi:10.1186/1478-811X-11-34 ![]() |
![]() ![]() | HILLER, K., & Metallo, C. M. (2013). Profiling metabolic networks to study cancer metabolism. Current Opinion in Biotechnology. doi:10.1016/j.copbio.2012.11.001 ![]() |
![]() ![]() | Müller, S., & HILLER, K. (2013). From multi-omics to basic structures of biological systems. Current Opinion in Biotechnology, 24, 1-3. doi:10.1016/j.copbio.2012.12.002 ![]() |
![]() ![]() | Krug, A., Gutbier, S., Zhao, L., Kullmann, C., Ivanova, V., Förster, S., Jagtap, S., MEISER, J., Leparc, G., Schildknecht, S., Adam, M., HILLER, K., Farhan, H., Brunner, T., Hartung, T., Sachinidis, A., & Leist, M. (2013). Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death and Disease. doi:10.1038/cddis.2014.166 ![]() |
![]() ![]() | McGuirk, S., Gravel, S.-P., Deblois, G., Papadopoli, D., Faubert, B., WEGNER, A., HILLER, K., Avizonis, D., Akavia, U. D., Jones, R. G., Giguère, V., & St-Pierre, J. (2013). PGC-1α supports glutamine metabolism in breast cancer. Cancer and Metabolism. ![]() |
![]() ![]() | HILLER, K. (2013). Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death and Differentiation. ![]() |
![]() ![]() | ROUME, H., MULLER, E., CORDES, T., Renaut, J., HILLER, K., & WILMES, P. (2013). A biomolecular isolation framework for eco-systems biology. ISME Journal, 7 (1), 110-121. doi:10.1038/ismej.2012.72 ![]() |
![]() ![]() | HILLER, K. (2012). Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. doi:10.1038/nature10602 ![]() |
ROUME, H., MULLER, E., CORDES, T., HILLER, K., & WILMES, P. (2012). A biomolecular isolation framework for eco-systems biology [Poster presentation]. 14th International Symposium on Microbial Ecology. |
![]() ![]() | WEGNER, A., CORDES, T., MICHELUCCI, A., & HILLER, K. (2012). The Application of Stable Isotope Assisted Metabolomics in Biomedicine. Current Biotechnology, 1, 88-97. ![]() |
![]() ![]() | HILLER, K. (2011). Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Molecular Systems Biology. doi:10.1038/msb.2011.56 ![]() |
ROUME, H., MULLER, E., CORDES, T., HILLER, K., & WILMES, P. (2011). Isolation of biomolecules from a single sample: the first step towards integrated omic analyses [Poster presentation]. 1st International Systems Biomedicine Symposium. |
![]() ![]() | HILLER, K., Metallo, C. M., Kelleher, J. K., & Stephanopoulos, G. (2010). Nontargeted Elucidation of Metabolic Pathways Using Stable-Isotope Tracers and Mass Spectrometry. Analytical Chemistry. doi:10.1021/ac1011574 ![]() |
![]() ![]() | Haddad, I., HILLER, K., Frimmersdorf, E., Benkert, B., Schomburg, D., & Jahn, D. (2009). An emergent self-organizing map based analysis pipeline for comparative metabolome studies. In Silico Biology. doi:10.3233/ISB-2009-0396 ![]() |
![]() ![]() | HILLER, K., Hangebrauk, J., Jäger, C., Spura, J., Schreiber, K., & Schomburg, D. (2009). MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis. Analytical Chemistry. doi:10.1021/ac802689c ![]() |
![]() ![]() | Choi, C., Münch, R., Leupold, S., Klein, J., Siegel, I., Thielen, B., Benkert, B., Kucklick, M., Schobert, M., Barthelmes, J., Ebeling, C., Haddad, Scheer, M., Grote, A., HILLER, K., Bunk, B., Schreiber, Retter, I., Schomburg, D., & Jahn, D. (2007). SYSTOMONAS — an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Research. doi:10.1093/nar/gkl823 ![]() |
![]() ![]() | Scheer, M., Klawonn, F., Münch, R., Grote, A., HILLER, K., Choi, C., Koch, I., Schobert, M., Härtig, E., Klages, U., & Jahn, D. (2006). JProGO: a novel tool for the functional interpretation of prokaryotic microarray data using Gene Ontology information. Nucleic Acids Research. doi:10.1093/nar/gkl329 ![]() |
![]() ![]() | HILLER, K., Schobert, M., Hundertmark, C., Jahn, D., & Münch, R. (2006). JVirGel 2.0: computational prediction of proteomes separated via two-dimensional gel electrophoresis under consideration of membrane and secreted proteins. Current Pharmaceutical Biotechnology. ![]() |
![]() ![]() | Bunk, B., Kucklick, M., Münch, R., Schobert, M., Jahn, D., & HILLER, K. (2006). MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data. Bioinformatics. doi:10.1093/bioinformatics/btl526 ![]() |
![]() ![]() | Münch, R., HILLER, K., Grote, A., Scheer, M., Klein, J., Schobert, M., & Jahn, D. (2005). Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes. Bioinformatics. doi:10.1093/bioinformatics/bti635 ![]() |
![]() ![]() | HILLER, K., Grote, A., Scheer, M., Münch, R., & Jahn, D. (2004). PrediSi: prediction of signal peptides and their cleavage positions. Nucleic Acids Research. doi:10.1093/nar/gkh378 ![]() |
![]() ![]() | HILLER, K., Schobert, M., Hundertmark, C., Jahn, D., & Münch, R. (2003). JVirGel: calculation of virtual two-dimensional protein gels. Nucleic Acids Research. doi:10.1093/nar/gkg536 ![]() |
![]() ![]() | Münch, R., HILLER, K., Barg, H., Heldt, D., Linz, S., Wingender, E., & Jahn, D. (2003). PRODORIC: prokaryotic database of gene regulation. Nucleic Acids Research. doi:10.1093/nar/gkg037 ![]() |