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Network analysis for systems biology
Chaiboonchoe, A.; Jurkowski, Wiktor; Pellet, J. et al.
2013In Prokop, Aleš; Csukás (Eds.) Springer book in Systems Biology, Vol.1: Systems Biology:, Integrative Biology and Simulation Tools
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Abstract :
[en] Network analysis is an essential component of systems biology approaches toward understanding the molecular and cellular interactions underlying biological systems functionalities and their perturbations in disease. Regulatory and signalling pathways, which involve DNA, RNA proteins and metabolites as key elements, coordinate most aspects of cellular functioning. Cellular processes, which are dependent on the structure and dynamics of gene regulatory networks, can be studied by employing a network representation of molecular interactions. In this chapter we describe several types of networks and how combination of different analytic approaches can be used to study diseases. We provide a list of selected tools for visualization and network analysis. We introduce protein-protein interaction networks, gene regulatory networks, signalling networks and metabolic networks. We then define concepts underlying network representation of cellular processes and molecular interactions. We finally discuss how the level of accuracy in inferring functional relationships influences the choice of methods applied for the analysis of a particular network type.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group)
- Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
Disciplines :
Biotechnology
Author, co-author :
Chaiboonchoe, A.
Jurkowski, Wiktor ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Pellet, J.
Glaab, Enrico  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Kolodkin, Alexey ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Raussel, Antonio
Le Béchec, Antony 
Meyniel, L.
Ballereau, S.
Crespo, Isaac ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Ahmed, H.
Volpert, V.
Lotteau, V.
Baliga, N.
del Sol, A.
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Auffray, C.
More authors (8 more) Less
External co-authors :
yes
Language :
English
Title :
Network analysis for systems biology
Publication date :
2013
Main work title :
Springer book in Systems Biology, Vol.1: Systems Biology:, Integrative Biology and Simulation Tools
Editor :
Prokop, Aleš
Csukás
Publisher :
Springer
Edition :
Springer book in Systems Biology, Vol.1:
Peer reviewed :
Peer reviewed
Commentary :
in press
Available on ORBilu :
since 25 June 2013

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