Article (Scientific journals)
Complexity of dopamine metabolism
Meiser, Johannes; Weindl, Daniel; Hiller, Karsten
2013In Cell Communication and Signaling, 11 (34)
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Keywords :
Parkinson's disease; dopamine; metabolism; oxidative stress; tyrosine hydroxylase
Abstract :
[en] Parkinson's disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenous neurotoxins whereas some DA derivatives show antioxidative effects. Therefore, DA metabolism is of special importance for neuronal redox-homeostasis and viability. In this review we highlight different aspects of dopamine metabolism in the context of PD and neurodegeneration. Since most reviews focus only on single aspects of the DA system, we will give a broader overview by looking at DA biosynthesis, sequestration, degradation and oxidation chemistry at the metabolic level, as well as at the transcriptional, translational and posttranslational regulation of all enzymes involved. This is followed by a short overview of cellular models currently used in PD research. Finally, we will address the topic from a medical point of view which directly aims to encounter PD.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Metabolomics (Hiller Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Meiser, Johannes ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Weindl, Daniel ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Hiller, Karsten ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Complexity of dopamine metabolism
Publication date :
2013
Journal title :
Cell Communication and Signaling
ISSN :
1478-811X
Publisher :
BioMed Central
Volume :
11
Issue :
34
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 24 June 2013

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