[en] Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Disciplines :
Biochimie, biophysique & biologie moléculaire
Auteur, co-auteur :
SCHWAMBORN, Jens Christian ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Knoblich, Juergen A.
Langue du document :
Anglais
Titre :
LIS1 and spindle orientation in neuroepithelial cells.
