Reference : Prominent psychiatric comorbidity in the dominantly inherited movement disorder myocl...
Scientific journals : Article
Human health sciences : Neurology
Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia.
Weissbach, Anne [> >]
Kasten, Meike [> >]
Grünewald, Anne [> >]
Bruggemann, Norbert [> >]
Trillenberg, Peter [> >]
Klein, Christine mailto [> >]
Hagenah, Johann [> >]
Parkinsonism and Related Disorders
Yes (verified by ORBilu)
[en] Adolescent ; Adult ; Aged ; Child ; Comorbidity ; Dystonic Disorders/epidemiology/genetics/psychology ; Female ; Heterozygote ; Humans ; Male ; Mental Disorders/epidemiology/genetics ; Middle Aged ; Mutation ; Neuropsychological Tests ; Sarcoglycans/genetics
[en] BACKGROUND: Neurological and psychiatric disorders show clinical overlap suggesting a shared pathophysiological background. We evaluated myoclonus-dystonia, a monogenic movement disorder as a disease model for inherited psychopathology. METHOD: We investigated 12 SGCE mutation carriers using standardized neurological and psychiatric examinations to assign DSM-IV diagnoses. Furthermore, we analyzed all studies in the Medline database which included psychiatric information on SGCE mutation-positive patients. RESULTS: Of our twelve SGCE mutation carriers, 10 were older than 16 years. Two of them (20%) reported psychiatric diagnoses before our examination, which resulted in at least one psychiatric diagnosis in seven (70%) patients, most frequently anxiety (60%), depression (30%) or both. Substance abuse was observed in 20%, whereas obsessive-compulsive disorders were absent. One mutation carrier showed Axis 2 features. In the literature analysis, the ten studies using standardized tools covering DSM-IV criteria reported prevalences similar to those in our sample. This was three times the frequency of psychiatric disorders detected in 13 studies using clinical history or patient report only. CONCLUSION: About two thirds of SGCE mutation carriers develop psychiatric comorbidity and >80% are previously undiagnosed.
Researchers ; Students
Copyright (c) 2013 Elsevier Ltd. All rights reserved.

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