| Reference : Prominent psychiatric comorbidity in the dominantly inherited movement disorder myocl... |
| Scientific journals : Article | |||
| Human health sciences : Neurology | |||
| http://hdl.handle.net/10993/24442 | |||
| Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia. | |
| English | |
| Weissbach, Anne [> >] | |
| Kasten, Meike [> >] | |
| Grünewald, Anne [> >] | |
| Bruggemann, Norbert [> >] | |
| Trillenberg, Peter [> >] | |
Klein, Christine  [> >] | |
| Hagenah, Johann [> >] | |
| 2013 | |
| Parkinsonism & related disorders | |
| 19 | |
| 4 | |
| 422-5 | |
| Yes (verified by ORBilu) | |
| 1353-8020 | |
| 1873-5126 | |
| England | |
| [en] Adolescent ; Adult ; Aged ; Child ; Comorbidity ; Dystonic Disorders/epidemiology/genetics/psychology ; Female ; Heterozygote ; Humans ; Male ; Mental Disorders/epidemiology/genetics ; Middle Aged ; Mutation ; Neuropsychological Tests ; Sarcoglycans/genetics | |
| [en] BACKGROUND: Neurological and psychiatric disorders show clinical overlap suggesting a shared pathophysiological background. We evaluated myoclonus-dystonia, a monogenic movement disorder as a disease model for inherited psychopathology. METHOD: We investigated 12 SGCE mutation carriers using standardized neurological and psychiatric examinations to assign DSM-IV diagnoses. Furthermore, we analyzed all studies in the Medline database which included psychiatric information on SGCE mutation-positive patients. RESULTS: Of our twelve SGCE mutation carriers, 10 were older than 16 years. Two of them (20%) reported psychiatric diagnoses before our examination, which resulted in at least one psychiatric diagnosis in seven (70%) patients, most frequently anxiety (60%), depression (30%) or both. Substance abuse was observed in 20%, whereas obsessive-compulsive disorders were absent. One mutation carrier showed Axis 2 features. In the literature analysis, the ten studies using standardized tools covering DSM-IV criteria reported prevalences similar to those in our sample. This was three times the frequency of psychiatric disorders detected in 13 studies using clinical history or patient report only. CONCLUSION: About two thirds of SGCE mutation carriers develop psychiatric comorbidity and >80% are previously undiagnosed. | |
| Researchers ; Students | |
| http://hdl.handle.net/10993/24442 | |
| Copyright (c) 2013 Elsevier Ltd. All rights reserved. |
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