KLEIN Christine

GRÜNEWALD, A.* , Arns, B.* , Meier, B., Brockmann, K., Tadic, V., & KLEIN, C. (2014). Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease? Antioxidants & redox signaling, 20 (13), 1955-60. doi:10.1089/ars.2013.5737

Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P.-J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., GRÜNEWALD, A., Seibler, P., KLEIN, C., Gevaert, K., Verstreken, P., & De Strooper, B. (2014). PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science, 344 (6180), 203-7. doi:10.1126/science.1249161

Lohmann, K., Schmidt, A., Schillert, A., Winkler, S., Albanese, A., Baas, F., Bentivoglio, A. R., Borngraber, F., Bruggemann, N., Defazio, G., Del Sorbo, F., Deuschl, G., Edwards, M. J., Gasser, T., Gomez-Garre, P., Graf, J., Groen, J. L., GRÜNEWALD, A., Hagenah, J., ... KLEIN, C. (2014). Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus? Movement Disorders, 29 (7), 921-7. doi:10.1002/mds.25791

Kumar, K. R., Blair, N. F., Vandebona, H., Liang, C., Ng, K., Sharpe, D. M., GRÜNEWALD, A., Golnitz, U., Saviouk, V., Rolfs, A., KLEIN, C., & Sue, C. M. (2013). Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. Journal of Neurology, 260 (10), 2516-22. doi:10.1007/s00415-013-7008-x

GRÜNEWALD, A.* , Kasten, M.* , Ziegler, A., & KLEIN, C. (2013). Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurology, 70 (9), 1186-91. doi:10.1001/jamaneurol.2013.488

Kumar, K. R., Ramirez, A., Gobel, A., Kresojevic, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., KLEIN, C., Kostic, V., & GRÜNEWALD, A. (2013). Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European Journal of Neurology, 20 (2), 402-5. doi:10.1111/j.1468-1331.2012.03817.x

Kasten, M., GRÜNEWALD, A., & KLEIN, C. (2013). Next-generation phenotyping and genomic incidental findings--reply. JAMA Neurology, 70 (12), 1590-1. doi:10.1001/jamaneurol.2013.4812

Rakovic, A., Shurkewitsch, K., Seibler, P., GRÜNEWALD, A., Zanon, A., Hagenah, J., Krainc, D., & KLEIN, C. (2013). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of biological chemistry, 288 (4), 2223-37. doi:10.1074/jbc.M112.391680

Alvarez-Fischer, D., Noelker, C., Vulinovic, F., GRÜNEWALD, A., Chevarin, C., KLEIN, C., Oertel, W. H., Hirsch, E. C., Michel, P. P., & Hartmann, A. (2013). Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PLoS ONE, 8 (4), 61700. doi:10.1371/journal.pone.0061700

Weissbach, A., Kasten, M., GRÜNEWALD, A., Bruggemann, N., Trillenberg, P., KLEIN, C., & Hagenah, J. (2013). Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia. Parkinsonism and Related Disorders, 19 (4), 422-5. doi:10.1016/j.parkreldis.2012.12.004

Freimann, K., Zschiedrich, K., Bruggemann, N., GRÜNEWALD, A., Pawlack, H., Hagenah, J., Lohmann, K., KLEIN, C., & Westenberger, A. (2013). Mortalin mutations are not a frequent cause of early-onset Parkinson disease. Neurobiology of Aging, 34 (11), 2694.e19-20. doi:10.1016/j.neurobiolaging.2013.05.021

Wortmann, S. B., Vaz, F. M., Gardeitchik, T., Vissers, L. E. L. M., Renkema, G. H., Schuurs-Hoeijmakers, J. H. M., Kulik, W., Lammens, M., Christin, C., Kluijtmans, L. A. J., Rodenburg, R. J., Nijtmans, L. G. J., GRÜNEWALD, A., KLEIN, C., Gerhold, J. M., Kozicz, T., van Hasselt, P. M., Harakalova, M., Kloosterman, W., ... de Brouwer, A. P. M. (2012). Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nature Genetics, 44 (7), 797-802. doi:10.1038/ng.2325

Schmidt, A., Kumar, K. R., Redyk, K., GRÜNEWALD, A., Leben, M., Munchau, A., Sue, C. M., Hagenah, J., Hartmann, H., Lohmann, K., Christen, H.-J., & KLEIN, C. (2012). Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations. Archives of Neurology, 69 (5), 668-70. doi:10.1001/archneurol.2012.187

GRÜNEWALD, A.* , Arns, B.* , Seibler, P., Rakovic, A., Munchau, A., Ramirez, A., Sue, C. M., & KLEIN, C. (2012). ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiology of Aging, 33 (8), 1843.e1-7. doi:10.1016/j.neurobiolaging.2011.12.035

Rakovic, A.* , GRÜNEWALD, A.* , Kottwitz, J., Bruggemann, N., Pramstaller, P. P., Lohmann, K., & KLEIN, C. (2011). Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS ONE, 6 (3), 16746. doi:10.1371/journal.pone.0016746

Abramov, A. Y., Gegg, M., GRÜNEWALD, A., Wood, N. W., KLEIN, C., & Schapira, A. H. V. (2011). Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS ONE, 6 (10), 25622. doi:10.1371/journal.pone.0025622

Arif, B., GRÜNEWALD, A., Fatima, A., Ramirez, A., Ali, A., Bruggemann, N., Wurfel, J., Rolfs, A., Lohmann, K., Malik, A., KLEIN, C., & Naz, S. (2011). An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech. Movement Disorders, 26 (12), 2279-83. doi:10.1002/mds.23860

GRÜNEWALD, A., Voges, L., Rakovic, A., Kasten, M., Vandebona, H., Hemmelmann, C., Lohmann, K., Orolicki, S., Ramirez, A., Schapira, A. H. V., Pramstaller, P. P., Sue, C. M., & KLEIN, C. (2010). Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS ONE, 5 (9), 12962. doi:10.1371/journal.pone.0012962

Rakovic, A., GRÜNEWALD, A., Seibler, P., Ramirez, A., Kock, N., Orolicki, S., Lohmann, K., & KLEIN, C. (2010). Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Human Molecular Genetics, 19 (16), 3124-37. doi:10.1093/hmg/ddq215

GRÜNEWALD, A., Gegg, M. E., Taanman, J.-W., King, R. H., Kock, N., KLEIN, C., & Schapira, A. H. V. (2009). Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Experimental Neurology, 219 (1), 266-73. doi:10.1016/j.expneurol.2009.05.027

GRÜNEWALD, A., Djarmati, A., Lohmann-Hedrich, K., Farrell, K., Zeller, J. A., Allert, N., Papengut, F., Petersen, B., Fung, V., Sue, C. M., O'Sullivan, D., Mahant, N., Kupsch, A., Chuang, R. S., Wiegers, K., Pawlack, H., Hagenah, J., Ozelius, L. J., Stephani, U., ... KLEIN, C. (2008). Myoclonus-dystonia: significance of large SGCE deletions. Human Mutation, 29 (2), 331-2. doi:10.1002/humu.9521

Brueggemann, N., Odin, P., GRÜNEWALD, A., Tadic, V., Hagenah, J., Seidel, G., Lohmann, K., KLEIN, C., & Djarmati, A. (2008). Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease. Neurology, 71 (16), 1294; author reply 1294. doi:10.1212/01.wnl.0000338439.00992.c7

Paus, S., GRÜNEWALD, A., KLEIN, C., Knapp, M., Zimprich, A., Janetzky, B., Moller, J. C., Klockgether, T., & Wullner, U. (2008). The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease. Movement Disorders, 23 (4), 599-602. doi:10.1002/mds.21901

GRÜNEWALD, A., Breedveld, G. J., Lohmann-Hedrich, K., Rohe, C. F., Konig, I. R., Hagenah, J., Vanacore, N., Meco, G., Antonini, A., Goldwurm, S., Lesage, S., Durr, A., Binkofski, F., Siebner, H., Munchau, A., Brice, A., Oostra, B. A., KLEIN, C., & Bonifati, V. (2007). Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis. Neurogenetics, 8 (2), 103-9. doi:10.1007/s10048-006-0072-y

Djarmati, A.* , Guzvic, M.* , GRÜNEWALD, A., Lang, A. E., Pramstaller, P. P., Simon, D. K., Kaindl, A. M., Vieregge, P., Nygren, A. O. H., Beetz, C., Hedrich, K., & KLEIN, C. (2007). Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Movement Disorders, 22 (12), 1708-14. doi:10.1002/mds.21370

Orth, M., Djarmati, A., Baumer, T., Winkler, S., GRÜNEWALD, A., Lohmann-Hedrich, K., Kabakci, K., Hagenah, J., KLEIN, C., & Munchau, A. (2007). Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene. Movement Disorders, 22 (14), 2090-6. doi:10.1002/mds.21674

Hedrich, K., Hagenah, J., Djarmati, A., Hiller, A., Lohnau, T., Lasek, K., GRÜNEWALD, A., Hilker, R., Steinlechner, S., Boston, H., Kock, N., Schneider-Gold, C., Kress, W., Siebner, H., Binkofski, F., Lencer, R., Munchau, A., & KLEIN, C. (2006). Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Archives of neurology, 63 (6), 833-8. doi:10.1001/archneur.63.6.833

KLEIN, C., GRÜNEWALD, A., & Hedrich, K. (2006). Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology, 66 (7), 1129-30; author reply 1129-30. doi:10.1212/01.wnl.0000220157.81513.85