Article (Scientific journals)
SOCS2: physiological and pathological functions.
Letellier, Elisabeth; Haan, Serge
2016In Frontiers in Bioscience (Elite Edition), 8, p. 189-204
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Keywords :
SOCS2
Abstract :
[en] Suppressors of cytokine signalling (SOCS) proteins are modulators of cytokine and growth factor signalling whose aberrant regulation has been linked to a variety of inflammatory and neoplastic diseases. SOCS proteins are able to act as substrate-recruiting component of E3-ubiquitin ligase complexes and target interacting proteins for degradation. At least some of the family members can also directly inhibit tyrosine kinases such as Janus Kinases (JAK). The most studied family members, CIS, SOCS1, SOCS2 and SOCS3 are important regulators of the JAK-STAT pathway. Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal structures of SOCS2 to discuss the potential effects of a selection of SOCS2 mutations that were identified in tumour tissues.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Haan, Serge ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
SOCS2: physiological and pathological functions.
Publication date :
2016
Journal title :
Frontiers in Bioscience (Elite Edition)
ISSN :
1945-0508
Publisher :
Frontiers in Bioscience, United States - New York
Volume :
8
Pages :
189-204
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fondation Cancer
Available on ORBilu :
since 07 January 2016

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