Article (Scientific journals)
Critical transitions in chronic disease: transferring concepts from ecology to systems medicine
Trefois, Christophe; Antony, Paul; Goncalves, Jorge et al.
2015In Current Opinion in Biotechnology, 34, p. 48-55
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Keywords :
Critical transitions; alternative stable states; hyteresis; chronic disease; early warning signals
Abstract :
[en] Ecosystems and biological systems are known to be inherently complex and to exhibit nonlinear dynamics. Diseases such as microbiome dysregulation or depression can be seen as complex systems as well and were shown to exhibit patterns of nonlinearity in their response to perturbations. These nonlinearities can be revealed by a sudden shift in system states, for instance from health to disease. The identification and characterization of early warning signals which could predict upcoming critical transitions is of primordial interest as prevention of disease onset is a major aim in health care. In this review, we focus on recent evidence for critical transitions in diseases and discuss the potential of such studies for therapeutic applications.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Trefois, Christophe ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Experimental Neurobiology group (R. Balling)
Antony, Paul ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Goncalves, Jorge ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Systems Control group (J. Goncalves)
Skupin, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Integrative Cell Signalling (A. Skupin)
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; Experimental Neurobiology group (R. Balling)
External co-authors :
no
Language :
English
Title :
Critical transitions in chronic disease: transferring concepts from ecology to systems medicine
Publication date :
August 2015
Journal title :
Current Opinion in Biotechnology
ISSN :
0958-1669
Publisher :
Elsevier Science
Special issue title :
Systems Biology
Volume :
34
Pages :
48-55
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 10 January 2015

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