Article (Scientific journals)
Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.
Letellier, Elisabeth; Schmitz, Martine; Baig, Komal et al.
2014In British Journal of Cancer, 111 (4), p. 726-35
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Keywords :
Colorectal cancer; SOCS; Biomarker
Abstract :
[en] BACKGROUND: Over the past years, some members of the family of suppressor of cytokine signalling (SOCS) proteins have emerged as potential tumour suppressors. This study aimed at investigating the clinical significance of SOCS proteins in colorectal carcinoma (CRC). METHODS: We integrated publicly available microarray expression data on CRC in humans, analysed the expression pattern of SOCSs and assessed the predictive power of SOCS2 and SOCS6 for diagnostic purposes by generating receiver operating characteristic curves. Using laser microdissected patient material we assessed SOCS expression on RNA and protein levels as well as their methylation status in an independent CRC patient cohort. Finally, we investigated the prognostic value of SOCS2 and SOCS6. RESULTS: The meta-analysis as well as the independent patient cohort analysis reveal a stage-independent downregulation of SOCS2 and SOCS6 and identify both molecules as diagnostic biomarkers for CRC. We demonstrate a different methylation pattern within the SOCS2 promoter between tumour tissue and normal control tissue in 25% of CRC patients. Furthermore, early CRC stage patients with low expression of SOCS2 display significantly shorter disease-free survival. CONCLUSIONS: Our data offers evidence that SOCS2 and SOCS6 levels are reduced in CRC and may serve as diagnostic biomarkers for CRC patients.
Disciplines :
Oncology
Author, co-author :
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Schmitz, Martine ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Baig, Komal ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Beaume, Nicolas ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Schwartz, C.
Frasquilho, S.
Antunes, L.
Marcon, N.
Nazarov, P. V.
Vallar, L.
Even, J.
Haan, Serge ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.
Publication date :
2014
Journal title :
British Journal of Cancer
ISSN :
1532-1827
Publisher :
Nature Publishing Group, United Kingdom
Volume :
111
Issue :
4
Pages :
726-35
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 09 October 2014

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