Article (Scientific journals)
SuperTarget and Matador: resources for exploring drug-target relationships
Guenther, Stefan; Kuhn, Michael; Dunkel, Mathias et al.
2008In Nucleic Acids Research, 36 (SI), p. 919-922
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Abstract :
[en] The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of medical articles or textbooks. Therefore, we developed a one-stop data warehouse, SuperTarget that integrates drug-related information about medical indication areas, adverse drug effects, drug metabolization, pathways and Gene Ontology terms of the target proteins. An easy-to-use query interface enables the user to pose complex queries, for example to find drugs that target a certain pathway, interacting drugs that are metabolized by the same cytochrome P450 or drugs that target the same protein but are metabolized by different enzymes. Furthermore, we provide tools for 2D drug screening and sequence comparison of the targets. The database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs; the vast majority of entries have pointers to the respective literature source. A subset of these drugs has been annotated with additional binding information and indirect interactions and is available as a separate resource called Matador. SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.de.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2012-040
Author, co-author :
Guenther, Stefan
Kuhn, Michael
Dunkel, Mathias
Campillos, Monica
Senger, Christian
Petsalaki, Evangelia
Ahmed, Jessica
Urdiales, Eduardo Garcia
Gewiess, Andreas
Jensen, Lars Juhl
Schneider, Reinhard ;  European Molecular Biology Laboratory - EMBL
Skoblo, Roman
Russell, Robert B.
Bourne, Philip E.
Bork, Peer
Preissner, Robert
More authors (6 more) Less
Language :
English
Title :
SuperTarget and Matador: resources for exploring drug-target relationships
Publication date :
2008
Journal title :
Nucleic Acids Research
ISSN :
1362-4962
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
36
Issue :
SI
Pages :
919-922
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 30 June 2014

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