| Reference : Spectrum of phenotypes and genotypes in Parkinson's disease. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/17125 | |||
| Spectrum of phenotypes and genotypes in Parkinson's disease. | |
| English | |
| Riess, Olaf [> >] | |
Krüger, Rejko  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit] | |
| Schulz, Jorg B. [> >] | |
| 2002 | |
| Journal of neurology | |
| 249 Suppl 3 | |
| III/15-20 | |
| Yes (verified by ORBilu) | |
| 0340-5354 | |
| Germany | |
| [en] Chromosome Mapping ; Chromosomes/genetics ; Genotype ; Humans ; Ligases/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Nucleoside-Phosphate Kinase/genetics ; Parkinson Disease/genetics ; Phenotype ; Synucleins ; Ubiquitin-Protein Ligases | |
| [en] The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases with autosomal recessive and autosomal dominant inheritance of PD suggest wide genetic heterogeneity of the disease. These gene loci in turn allow now a more specific clinical investigation of affected families to study the clinical heterogeneity of PD. The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease. | |
| Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) | |
| http://hdl.handle.net/10993/17125 | |
| 10.1007/s00415-002-1303-2 |
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