Profil

GHELFI Jenny

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology

Main Referenced Co-authors
DELCAMBRE, Sylvie  (9)
GRÜNEWALD, Anne  (9)
Klein, Christine (6)
HILLER, Karsten  (5)
Trinh, Joanne (5)
Main Referenced Keywords
Parkinson's disease (4); Parkinson’s disease (3); Mitochondria (2); PINK1 (2); aldehyde dehydrogenase 1A1 (ALDH1A1) (1);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (4)
Luxembourg Centre for Systems Biomedicine (LCSB): Metabolomics (Hiller Group) (4)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group) (2)
Luxembourg Centre for Systems Biomedicine (LCSB) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (11)
Neurology (4)
Genetics & genetic processes (3)
Biotechnology (1)
Microbiology (1)

Publications (total 15)

The most downloaded
444 downloads
Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025 https://hdl.handle.net/10993/51271

The most cited

715 citations (Scopus®)

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110 https://hdl.handle.net/10993/2256

Zhang, J., Keibler, M. A., Dong, W., GHELFI, J., Cordes, T., Kanashova, T., Pailot, A., LINSTER, C., DITTMAR, G., Metallo, C. M., Lautenschlaeger, T., HILLER, K., & Stephanopoulos, G. (19 October 2023). Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines, 11 (10), 2842. doi:10.3390/biomedicines11102842
Peer Reviewed verified by ORBi

Trinh, J., Hicks, A. A., König, I. R., Delcambre, S., Lüth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilariño-Güell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostić, V., Lang, A. E., Brüggemann, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (July 2023). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease. Brain, 146 (7), 2753–2765. doi:10.1093/brain/awac464
Peer reviewed

Trinh, J., Hicks, A. A., Koenig, I. R., Delcambre, S., Lueth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilarino-Guell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostic, V., Lang, A. E., Brueggeman, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (2022). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51280. doi:10.1101/2022.05.17.22275087

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446
Peer Reviewed verified by ORBi

Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025
Peer reviewed

Borsche, M., Koenig, I., Delcambre, S., Petrucci, S., Balck, A., Brueggemann, N., Zimprich, A., Wasner, K., Cardoso Pereira, S. L., Avenali, M., Deuschle, C., Badanjak, K., Ghelfi, J., Gasser, T., Kasten, M., Rosenstiel, P., Lohmann, K., Brockmann, K., Valente, E. M., ... Klein, C. (2020). Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain: a Journal of Neurology. doi:10.1093/NTR/NTV039
Peer Reviewed verified by ORBi

Neumann, M. A.-C.* , Grossmann, D.* , Schimpf-Linzenbold, S., Dayan, D., Stingl, K., Ben-Menachem, R., Pines, O., Massart, F., Delcambre, S., Ghelfi, J., Bohler, J., Strom, T., Kessel, A., Azem, A., Schöls, L., Grünewald, A., Wissinger, B., & Krüger, R. (2020). Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. doi:10.1038/s41598-020-73557-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delcambre, S., Ghelfi, J., Ouzren, N., Grandmougin, L., Delbrouck, C., Seibler, P., Wasner, K., Aasly, J., Klein, C., Trinh, J., Cardoso Pereira, S. L., & Grünewald, A. (2020). Mitochondrial Mechanisms of LRRK2 G2019S Penetrance. Frontiers in Neurology. doi:10.3389/fneur.2020.00881
Peer Reviewed verified by ORBi

Ouzren, N., Delcambre, S., Ghelfi, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & Grünewald, A. (August 2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86 (2), 324-326. doi:10.1002/ana.25510
Peer Reviewed verified by ORBi

Grossmann, D., Berenguer, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Hérouël, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Grünewald, A., & Krüger, R. (2019). Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease. Antioxidants & redox signaling. doi:10.1089/ars.2018.7718
Peer reviewed

Meiser, J., Delcambre, S., Wegner, A., Jäger, C., Ghelfi, J., Fouquier d'Hérouël, A., Dong, X., Weindl, D., Stautner, C., Nonnenmacher, Y., Michelucci, A., Popp, O., Giesert, F., Schildknecht, S., Kraemer, L., Schneider, J. G., Woitalla, D., Wurst, W., Skupin, A., ... Hiller, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019
Peer Reviewed verified by ORBi

Meiser, J., Kraemer, L., Sapcariu, S., Battello, N., Ghelfi, J., Fouquier d'Hérouël, A., Skupin, A., & Hiller, K. (2015). Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. Journal of Biological Chemistry. doi:10.1074/jbc.M115.676817
Peer reviewed

Jäger, C.* , Glaab, E.* , Michelucci, A.* , Binz, T., Köglsberger, S., Garcia, P., Trezzi, J.-P., Ghelfi, J., Balling, R., & Buttini, M. (2015). The Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury. American Journal of Pathology, 185 (6), 1699-1712. doi:10.1016/j.ajpath.2015.02.016
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Sapcariu, S., Kanashova, T., Weindl, D., Ghelfi, J., Dittmar, G., & Hiller, K. (2014). Simultaneous extraction of proteins and metabolites from cells in culture. MethodsX. doi:10.1016/j.mex.2014.07.002
Peer Reviewed verified by ORBi

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C., Medina, E., Balling, R., & Hiller, K. (2013). Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1218599110
Peer Reviewed verified by ORBi

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