Profil

DELCAMBRE Sylvie

Main Referenced Co-authors
GRÜNEWALD, Anne  (14)
GHELFI, Jenny  (9)
Klein, Christine (9)
Trinh, Joanne (6)
ANTONY, Paul  (5)
Main Referenced Keywords
Mitochondria (4); Parkinson's disease (4); Parkinson’s disease (3); PINK1 (3); Dopamine (2);
Main Referenced Unit & Research Centers
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) (3)
LIH - Luxembourg Institute of Health (1)
Luxembourg Centre for Systems Biomedicine (LCSB) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (A. Grünewald Group) (1)
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (14)
Neurology (4)
Genetics & genetic processes (3)
Phytobiology (plant sciences, forestry, mycology...) (1)
Life sciences: Multidisciplinary, general & others (1)

Publications (total 20)

The most downloaded
1259 downloads
Delcambre, S. (2016). In vitro Metabolic Studies of Dopamine Synthesis and the Toxicity of L-DOPA in Human Cells [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/28204 https://hdl.handle.net/10993/28204

The most cited

125 citations (WOS)

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446 https://hdl.handle.net/10993/49712

MULICA, P., Venegas, C., LANDOULSI, Z., BADANJAK, K., DELCAMBRE, S., TZIORTZIOU, M., HEZZAZ, S., Ghelfi, J., SMAJIC, S., SCHWAMBORN, J. C., Krüger, R., ANTONY, P., MAY, P., GLAAB, E., GRÜNEWALD, A.* , & Pereira, S. L.*. (20 September 2023). Comparison of two protocols for the generation of iPSC-derived human astrocytes. Biological Procedures Online, 25 (1), 26. doi:10.1186/s12575-023-00218-x
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Trinh, J., Hicks, A. A., König, I. R., Delcambre, S., Lüth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilariño-Güell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostić, V., Lang, A. E., Brüggemann, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (July 2023). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease. Brain, 146 (7), 2753–2765. doi:10.1093/brain/awac464
Peer reviewed

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., Antony, P., Boussaad, I., Bobbili, D. R., Sreelatha, A. A. K., Pavelka, L., Klein, C., Seibler, P., Glaab, E., Sharma, M., Krüger, R., May, P., & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877

Pereira, S. L., Grossmann, D., Delcambre, S., Hermann, A., & Grünewald, A. (2023). Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Current Opinion in Neurobiology, 80, 102720. doi:10.1016/j.conb.2023.102720
Peer Reviewed verified by ORBi

Castelo Rueda, M. P., Zanon, A., Gilmozzi, V., Lavdas, A., Raftopoulou, A., Delcambre, S., Del Greco, F., Klein, C., Grünewald, A., Pramstaller, P., Hicks, A., & Pichler, I. (2023). Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers. NPJ Parkinson's Disease. doi:10.1038/s41531-023-00499-9
Peer Reviewed verified by ORBi

Trinh, J., Hicks, A. A., Koenig, I. R., Delcambre, S., Lueth, T., Schaake, S., Wasner, K., Ghelfi, J., Borsche, M., Vilarino-Guell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostic, V., Lang, A. E., Brueggeman, N., Pramstaller, P. P., Pichler, I., ... Grünewald, A. (2022). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51280. doi:10.1101/2022.05.17.22275087

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grünewald, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446
Peer Reviewed verified by ORBi

Wasner, K., Smajic, S., Ghelfi, J., Delcambre, S., Prada-Medina, C. A., Knappe, E., Arena, G., Mulica, P., Agyeah, G., Rakovic, A., Boussaad, I., Badanjak, K., Ohnmacht, J., Gerardy, J.-J., Takanashi, M., Trinh, J., Mittelbronn, M., Hattori, N., Klein, C., ... Grünewald, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025
Peer reviewed

Hörmann, P., Delcambre, S., Hanke, J., Geffers, R., Leist, M., & Hiller, K. (2021). Impairment of neuronal mitochondrial function by l-DOPA in the absence of oxygen-dependent auto-oxidation and oxidative cell damage. Cell Death Discovery. doi:10.1038/S41420-021-00547-4
Peer Reviewed verified by ORBi

Badanjak, K., Mulica, P., Smajic, S., Delcambre, S., Tranchevent, L.-C., Diederich, N., Rauen, T., Schwamborn, J. C., Glaab, E., Cowley, S. A., Antony, P., Pereira, S. L., Venegas, C., & Grünewald, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, 740758. doi:10.3389/fcell.2021.740758
Peer Reviewed verified by ORBi

Dulovic-Mahlow, M.* , König, I. R.* , Trinh, J.* , Haissatou Diaw, S., Urban, P. P., Knappe, E., Kuhnke, N., Ingwersen, L.-C., Hinrichs, F., Weber, J., Kupnicka, P., Balck, A., Delcambre, S., Vollbrandt, T., Grünewald, A., Klein, C., Seibler, P., & Lohmann, K. (2020). Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity. Annals of Neurology. doi:10.1002/ana.25942
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Borsche, M., Koenig, I., Delcambre, S., Petrucci, S., Balck, A., Brueggemann, N., Zimprich, A., Wasner, K., Cardoso Pereira, S. L., Avenali, M., Deuschle, C., Badanjak, K., Ghelfi, J., Gasser, T., Kasten, M., Rosenstiel, P., Lohmann, K., Brockmann, K., Valente, E. M., ... Klein, C. (2020). Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain: a Journal of Neurology. doi:10.1093/NTR/NTV039
Peer Reviewed verified by ORBi

Neumann, M. A.-C.* , Grossmann, D.* , Schimpf-Linzenbold, S., Dayan, D., Stingl, K., Ben-Menachem, R., Pines, O., Massart, F., Delcambre, S., Ghelfi, J., Bohler, J., Strom, T., Kessel, A., Azem, A., Schöls, L., Grünewald, A., Wissinger, B., & Krüger, R. (2020). Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. doi:10.1038/s41598-020-73557-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delcambre, S., Ghelfi, J., Ouzren, N., Grandmougin, L., Delbrouck, C., Seibler, P., Wasner, K., Aasly, J., Klein, C., Trinh, J., Cardoso Pereira, S. L., & Grünewald, A. (2020). Mitochondrial Mechanisms of LRRK2 G2019S Penetrance. Frontiers in Neurology. doi:10.3389/fneur.2020.00881
Peer Reviewed verified by ORBi

Ouzren, N., Delcambre, S., Ghelfi, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & Grünewald, A. (August 2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86 (2), 324-326. doi:10.1002/ana.25510
Peer Reviewed verified by ORBi

Singh, P. K.* , van den Berg, P. R.* , Long, M. D., Vreugdenhil, A., Grieshober, L., Ochs-Balcom, H. M., Wang, J., Delcambre, S., Heikkinen, S., Carlberg, C., Campbell, M. J., & Sucheston-Campbell, L. E. (2017). Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics. doi:10.1186/s12864-017-3481-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delcambre, S. (2016). In vitro Metabolic Studies of Dopamine Synthesis and the Toxicity of L-DOPA in Human Cells [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/28204

Doppler, M., Kluger, B., Bueschl, C., Schneider, C., Krska, R., Delcambre, S., Hiller, K., Lemmens, M., & Schuhmacher, R. (2016). Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. International Journal of Molecular Sciences. doi:10.3390/IJMS17071017
Peer reviewed

Delcambre, S. (2016). Dopamine Metabolism and Reactive Oxygen Species Production. In L. Buhlman (Ed.), Mitochondrial Mechanisms of Degeneration and Repair in Parkinson’s Disease (pp. 25-49). Springer. doi:10.1007/978-3-319-42139-1_3
Peer reviewed

Meiser, J., Delcambre, S., Wegner, A., Jäger, C., Ghelfi, J., Fouquier d'Hérouël, A., Dong, X., Weindl, D., Stautner, C., Nonnenmacher, Y., Michelucci, A., Popp, O., Giesert, F., Schildknecht, S., Kraemer, L., Schneider, J. G., Woitalla, D., Wurst, W., Skupin, A., ... Hiller, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019
Peer Reviewed verified by ORBi

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