![]() ![]() | ARENA, G., LANDOULSI, Z., GROSSMANN, D., Payne, T., VITALI, A., DELCAMBRE, S., BARON, A., ANTONY, P., BOUSSAAD, I., BOBBILI, D. R., Sreelatha, A. A. K., PAVELKA, L., J Diederich, N., Klein, C., Seibler, P., GLAAB, E., Foltynie, T., Bandmann, O., Sharma, M., ... COURAGE‐PD Consortium. (2024). Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease. Annals of Neurology. doi:10.1002/ana.26949 ![]() |
![]() ![]() | Diaw, S. H., DELCAMBRE, S., Much, C., Ott, F., Kostic, V. S., Gajos, A., Münchau, A., Zittel, S., Busch, H., GRÜNEWALD, A., Klein, C., & Lohmann, K. (April 2024). DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery. Neurogenetics, 25 (2), 141 - 147. doi:10.1007/s10048-024-00752-0 ![]() |
![]() ![]() | MULICA, P., Venegas, C., LANDOULSI, Z., BADANJAK, K., DELCAMBRE, S., TZIORTZIOU, M., HEZZAZ, S., Ghelfi, J., SMAJIC, S., SCHWAMBORN, J. C., Krüger, R., ANTONY, P., MAY, P., GLAAB, E., GRÜNEWALD, A.* , & Pereira, S. L.*. (20 September 2023). Comparison of two protocols for the generation of iPSC-derived human astrocytes. Biological Procedures Online, 25 (1), 26. doi:10.1186/s12575-023-00218-x ![]() * These authors have contributed equally to this work. |
![]() ![]() | Trinh, J., Hicks, A. A., König, I. R., DELCAMBRE, S., Lüth, T., Schaake, S., Wasner, K., GHELFI, J., Borsche, M., Vilariño-Güell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostić, V., Lang, A. E., Brüggemann, N., Pramstaller, P. P., Pichler, I., ... GRÜNEWALD, A. (July 2023). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease. Brain, 146 (7), 2753–2765. doi:10.1093/brain/awac464 ![]() |
![]() ![]() | ARENA, G., LANDOULSI, Z., Grossmann, D., Vitali, A., DELCAMBRE, S., BARON, A., ANTONY, P., BOUSSAAD, I., BOBBILI, D. R., Sreelatha, A. A. K., PAVELKA, L., Klein, C., Seibler, P., GLAAB, E., Sharma, M., KRÜGER, R., MAY, P., & GRÜNEWALD, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05.12.23289877. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/55367. doi:10.1101/2023.05.12.23289877 |
![]() ![]() | Castelo Rueda, M. P., Zanon, A., Gilmozzi, V., Lavdas, A., Raftopoulou, A., DELCAMBRE, S., Del Greco, F., Klein, C., GRÜNEWALD, A., Pramstaller, P., Hicks, A., & Pichler, I. (2023). Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers. NPJ Parkinson's Disease. doi:10.1038/s41531-023-00499-9 ![]() |
![]() ![]() | Pereira, S. L., Grossmann, D., DELCAMBRE, S., Hermann, A., & GRÜNEWALD, A. (2023). Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Current Opinion in Neurobiology, 80, 102720. doi:10.1016/j.conb.2023.102720 ![]() |
![]() ![]() | Trinh, J., Hicks, A. A., Koenig, I. R., DELCAMBRE, S., Lueth, T., Schaake, S., Wasner, K., GHELFI, J., Borsche, M., Vilarino-Guell, C., Hentati, F., Germer, E. L., Bauer, P., Takanashi, M., Kostic, V., Lang, A. E., Brueggeman, N., Pramstaller, P. P., Pichler, I., ... GRÜNEWALD, A. (2022). Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/51280. doi:10.1101/2022.05.17.22275087 |
![]() ![]() | SMAJIC, S., Prada-Medina, C. A., LANDOULSI, Z., GHELFI, J., DELCAMBRE, S., Dietrich, C., JARAZO, J., Henck, J., Balachandran, S., PACHCHEK, S., Morris, C. M., ANTONY, P., Timmermann, B., Sauer, S., Pereira, S. L., SCHWAMBORN, J. C., MAY, P., GRÜNEWALD, A., & Spielmann, M. (29 April 2022). Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain: a Journal of Neurology, 145 (3), 964-978. doi:10.1093/brain/awab446 ![]() |
![]() ![]() | Wasner, K., SMAJIC, S., GHELFI, J., DELCAMBRE, S., Prada-Medina, C. A., Knappe, E., ARENA, G., MULICA, P., AGYEAH, G., Rakovic, A., BOUSSAAD, I., BADANJAK, K., OHNMACHT, J., GERARDY, J.-J., Takanashi, M., Trinh, J., MITTELBRONN, M., Hattori, N., Klein, C., ... GRÜNEWALD, A. (2022). Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation. Movement disorders : official journal of the Movement Disorder Society. doi:10.1002/mds.29025 ![]() |
![]() ![]() | Hörmann, P., DELCAMBRE, S., Hanke, J., Geffers, R., Leist, M., & Hiller, K. (2021). Impairment of neuronal mitochondrial function by l-DOPA in the absence of oxygen-dependent auto-oxidation and oxidative cell damage. Cell Death Discovery. doi:10.1038/S41420-021-00547-4 ![]() |
![]() ![]() | BADANJAK, K., MULICA, P., SMAJIC, S., DELCAMBRE, S., TRANCHEVENT, L.-C., Diederich, N., Rauen, T., SCHWAMBORN, J. C., GLAAB, E., Cowley, S. A., ANTONY, P., Pereira, S. L., Venegas, C., & GRÜNEWALD, A. (2021). iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, 740758. doi:10.3389/fcell.2021.740758 ![]() |
![]() ![]() | Dulovic-Mahlow, M.* , König, I. R.* , Trinh, J.* , Haissatou Diaw, S., Urban, P. P., Knappe, E., Kuhnke, N., Ingwersen, L.-C., Hinrichs, F., Weber, J., Kupnicka, P., Balck, A., DELCAMBRE, S., Vollbrandt, T., GRÜNEWALD, A., Klein, C., Seibler, P., & Lohmann, K. (2020). Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity. Annals of Neurology. doi:10.1002/ana.25942 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Borsche, M., Koenig, I., DELCAMBRE, S., Petrucci, S., Balck, A., Brueggemann, N., Zimprich, A., WASNER, K., CARDOSO PEREIRA, S. L., Avenali, M., Deuschle, C., BADANJAK, K., GHELFI, J., Gasser, T., Kasten, M., Rosenstiel, P., Lohmann, K., Brockmann, K., Valente, E. M., ... Klein, C. (2020). Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain: a Journal of Neurology. doi:10.1093/NTR/NTV039 ![]() |
![]() ![]() | NEUMANN, M. A.-C.* , GROSSMANN, D.* , Schimpf-Linzenbold, S., Dayan, D., Stingl, K., Ben-Menachem, R., Pines, O., MASSART, F., DELCAMBRE, S., GHELFI, J., BOHLER, J., Strom, T., Kessel, A., Azem, A., Schöls, L., GRÜNEWALD, A., Wissinger, B., & KRÜGER, R. (2020). Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. doi:10.1038/s41598-020-73557-4 ![]() * These authors have contributed equally to this work. |
![]() ![]() | DELCAMBRE, S., GHELFI, J., Ouzren, N., GRANDMOUGIN, L., Delbrouck, C., Seibler, P., WASNER, K., Aasly, J., Klein, C., Trinh, J., CARDOSO PEREIRA, S. L., & GRÜNEWALD, A. (2020). Mitochondrial Mechanisms of LRRK2 G2019S Penetrance. Frontiers in Neurology. doi:10.3389/fneur.2020.00881 ![]() |
![]() ![]() | OUZREN, N., DELCAMBRE, S., GHELFI, J., Seibler, P., Farrer, M. J., König, I., Aasly, J. O., Trinh, J., Klein, C., & GRÜNEWALD, A. (August 2019). MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Annals of Neurology, 86 (2), 324-326. doi:10.1002/ana.25510 ![]() |
![]() ![]() | Singh, P. K.* , van den Berg, P. R.* , Long, M. D., Vreugdenhil, A., Grieshober, L., Ochs-Balcom, H. M., Wang, J., DELCAMBRE, S., Heikkinen, S., Carlberg, C., Campbell, M. J., & Sucheston-Campbell, L. E. (2017). Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics. doi:10.1186/s12864-017-3481-4 ![]() * These authors have contributed equally to this work. |
![]() ![]() | DELCAMBRE, S. (2016). In vitro Metabolic Studies of Dopamine Synthesis and the Toxicity of L-DOPA in Human Cells [Doctoral thesis, Unilu - University of Luxembourg]. ORBilu-University of Luxembourg. https://orbilu.uni.lu/handle/10993/28204 |
![]() ![]() | Doppler, M., Kluger, B., Bueschl, C., Schneider, C., Krska, R., DELCAMBRE, S., HILLER, K., Lemmens, M., & Schuhmacher, R. (2016). Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. International Journal of Molecular Sciences. doi:10.3390/IJMS17071017 ![]() |
![]() ![]() | DELCAMBRE, S. (2016). Dopamine Metabolism and Reactive Oxygen Species Production. In L. Buhlman (Ed.), Mitochondrial Mechanisms of Degeneration and Repair in Parkinson’s Disease (pp. 25-49). Springer. doi:10.1007/978-3-319-42139-1_3 ![]() |
![]() ![]() | MEISER, J., DELCAMBRE, S., WEGNER, A., Jäger, C., GHELFI, J., FOUQUIER DU0027HÉROUËL, A., DONG, X., WEINDL, D., Stautner, C., NONNENMACHER, Y., MICHELUCCI, A., Popp, O., Giesert, F., Schildknecht, S., KRAEMER, L., Schneider, J. G., Woitalla, D., Wurst, W., SKUPIN, A., ... HILLER, K. (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease, 89, 112-125. doi:10.1016/j.nbd.2016.01.019 ![]() |