Article (Scientific journals)
The plexus model for the inference of ancestral multidomain proteins.
Wiedenhoeft, John; Krause, Roland; Eulenstein, Oliver
2011In IEEE/ACM Transactions on Computational Biology and Bioinformatics, 8 (4), p. 890-901
Peer Reviewed verified by ORBi
 

Files


Full Text
manuscript_revision_2.pdf
Author postprint (1.05 MB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Algorithms; Computational Biology/methods; Evolution, Molecular; Models, Biological; Phylogeny; Protein Structure, Tertiary; Proteins/chemistry/genetics
Abstract :
[en] Interactions of protein domains control essential cellular processes. Thus, inferring the evolutionary histories of multidomain proteins in the context of their families can provide rewarding insights into protein function. However, methods to infer these histories are challenged by the complexity of macroevolutionary events. Here, we address this challenge by describing an algorithm that computes a novel network-like structure, called plexus, which represents the evolution of domains and their combinations. Finally, we demonstrate the performance of this algorithm with empirical data sets.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Wiedenhoeft, John
Krause, Roland  ;  Freie Universität Berlin > Computer Science
Eulenstein, Oliver
Language :
English
Title :
The plexus model for the inference of ancestral multidomain proteins.
Publication date :
2011
Journal title :
IEEE/ACM Transactions on Computational Biology and Bioinformatics
ISSN :
1557-9964
Publisher :
IEEE Computer Society, United States - New York
Volume :
8
Issue :
4
Pages :
890-901
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 04 May 2013

Statistics


Number of views
55 (0 by Unilu)
Number of downloads
559 (0 by Unilu)

Scopus citations®
 
8
Scopus citations®
without self-citations
7
WoS citations
 
7

Bibliography


Similar publications



Contact ORBilu